Elevated HABP1 protein expression correlates with progression and poor survival in patients with gastric cancer

Abstract

BackgroundHyaluronic acid-binding protein 1 (HABP1/gC1qR/p32) has been recently implicated in oncogenesis and cancer progression in various malignancies; however, its clinical role in gastric cancer (GC) is still unclear.Patients and methodsFirst, HABP1 expression was determined by Western blot analysis and immunohistochemistry. Then, we evaluated the expression of HABP1 and its clinical significance in tumor tissues from 181 patients with GC.ResultsExpression of HABP1 protein in GC tissues was noticeably higher than that in adjacent nonneoplastic tissues (P=0.018). Increased HABP1 expression was significantly associated with tumor, node, and metastasis (TNM) stage (P=0.006), depth of invasion (P=0.001), lymph node metastasis (P=0.001), liver metastasis (P=0.024), and peritoneum metastasis (P=0.009). Patients with high expression of HABP1 had poor overall survival rate (P<0.001). In addition, histologic grade (P=0.017), TNM stage (P<0.001), Borrmann grouping (P<0.001), depth of invasion (P<0.001), lymph node metastasis (P<0.001), liver metastasis (P=0.010), and tumor size (P<0.001) were independent prognostic factors for overall survival. Multivariate Cox regression analysis revealed that HABP1 (P=0.004), histologic grade (P=0.047), TNM stage (P<0.001), Borrmann grouping (P<0.001), and liver metastasis (P=0.038) were independent factors for overall survival in patients with GC.ConclusionThese findings demonstrated that HABP1 was an indicator for GC progression and poor survival, which highlighted its potential role as a therapeutic target for GCs.

Multi-functional, multicompartmental hyaluronan-binding protein 1 (HABP1/p32/gC1qR): implication in cancer progression and metastasis

“…Selective knockdown of p32/HABP1 by RNA interference inhibits the growth of prostate cancer cell lines resulting from G1/S cell cycle arrest via downregulation of cyclinD1 and increased expression of p21 [ 141 ]. Even in case of gastric cancer, elevated level of HABP1 is correlated with progression and poor prognosis of the patients [ 142 ]. Gene polymorphism study in northern Chinese women with HABP1 upregulation, indicated the association of the single neucleotide polymorphism of minor allele of rs2285747 with increased risk of breast cancer [ 143 ].…”

GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells

“…Furthermore, studies have shown increased gC1qR expression in most cancer types where it supports metastasis. Thus, augmented gC1qR levels correlate with poor prognosis in cancer patients (15)(16)(17)(18)(19)(20)(21). Until now, it is assumed that mitochondrial gC1qR protein maintains mitochondria function by regulating mitochondrial protein translation (22,23).…”

Evaluation of KI-67, Apoptosis, and Hyaluronic Acid in Grading Retinoblastoma

“…Li et al (2016) also further asserted that HA over immunostaining would have a biological effect on the progression of hepatic carcinoma. While Gao et al (2016) discerned the role of HABP-1 as HA protein binding whose immunostaining increases as an HA elevation indicator which increases the progression of gastric cancer cells and decreases the patients survival rate.…”