Elevated histidine decarboxylase activity in the kidney of the pregnant mouse

Rosengren, E.; Steinhardt, Claudia

doi:10.1007/bf02156410

Cited by 22 publications

(10 citation statements)

References 6 publications

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“…That hormones control kidney histidine decarboxylase activity is indicated by the observation of Rosengren & Steinhardt (1961) that histamine formation in the female kidney is several times higher than in the male. This sex difference is confirmed in the present study and is shown to exist in different strains of mice.…”

Section: Discussionmentioning

confidence: 99%

Biosynthesis of histamine and putrescine in mice during post‐natal development and its hormone dependence.

Henningsson¹,

Rosengren²

1975

The Journal of Physiology

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1. Histidine decarboxylase and ornithine decarboxylase activities were determined in mouse kidney and liver during post‐natal development. 2. The content of histamine, putrescine, spermidine and spermine was examined in kidney and liver and in the urine of adult male and female mice. 3. Histamine formation by the kidney was high in both sexes when determined a few days after birth but decreased during weaning. Thereafter, a distinct sex difference was established in that in the female kidney the level of histidine decarboxylase rose several‐fold during adolescence while in the male the level was still further reduced. 4. Putrescine formation by mouse kidney was low in both sexes up to three weeks of age whereafter the amine formation in the male increased conspicuously whereas that of the female kidney remained low. 5. The observed sex differences in tissue enzyme activities were reflected in concomitant differences in the amount of the diamines excreted in the urine. 6. No correlation was found between the actual enzyme levels and the assayed tissue content of histamine, putrescine, spermidine and spermine. 7. Following gonadectomy, the activities of both decarboxylases were significantly altered. Ornithine decarboxylase activity of male kidney and histidine decarboxylase activity of female kidney were strikingly reduced. 8. In the mouse liver, the two decarboxylases displayed no changes comparable with that of the kidney during development.

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Section: Discussionmentioning

confidence: 99%

Biosynthesis of histamine and putrescine in mice during post‐natal development and its hormone dependence.

Henningsson¹,

Rosengren²

1975

The Journal of Physiology

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“…In the first place, even in the non-pregnant state the female mouse kidney is richer in histidine decarboxylase than the male (Rosengren & Steinhardt, 1961), thus indicating an effect of sex hormones on histidine decarboxylase activity. Further, as mentioned above, the urinary excretion of histidine is increased in pregnancy.…”

Section: Histamine Formation In Vivomentioning

confidence: 99%

“…In the rat embryo, as already stated, the liver is the organ particularly rich in histidine decarboxylase. In mouse pregnancy the kidney of the mother has been shown to form histamine at high rates (Rosengren & Steinhardt, 1961). It was assumed a priori that in the mouse foetus also the liver and kidney should be rich sources of histidine decarboxylase.…”

Section: Histamine Formation In Vivomentioning

confidence: 99%

Histamine metabolism in the pregnant mouse

Rosengren¹

1963

The Journal of Physiology

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“…Testosterone increases the proportion of methylhistamine in the urine of castrated male and female rats (Westling & Wetterqvist, 1962). In mice also, a sex difference in histamine metabolism has been disclosed in that the kidney of the female, even in non-pregnancy, is endowed with a much higher histamine forming capacity than that of the male (Rosengren & Steinhardt, 1961).…”

Section: Introductionmentioning

confidence: 99%