Elevated Intrasynaptic Dopamine Release in Tourette’s Syndrome Measured by PET

Singer, Harvey S.; Szymanski, S.; Giuliano, Joseph; Yokoi, Fuji; Doğan, Ahmet; Brašić, James Robert; Zhou, Yun; Grace, Anthony A.; Wong, Dean F.

doi:10.1176/appi.ajp.159.8.1329

Cited by 243 publications

(146 citation statements)

References 49 publications

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“…Single-photon emission computed tomography investigations in TS have found higher DAT binding in the right caudate [635], the striatum [636-639], the putamen after amphetamine challenge [640], and the basal ganglia [641]. However, a handful of studies have found no differences in striatal DAT binding in TS [639,642-644].…”

Section: Reviewmentioning

confidence: 99%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

254

207

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This review summarizes evidence of dysregulated reward circuitry function in a range of neurodevelopmental and psychiatric disorders and genetic syndromes. First, the contribution of identifying a core mechanistic process across disparate disorders to disease classification is discussed, followed by a review of the neurobiology of reward circuitry. We next consider preclinical animal models and clinical evidence of reward-pathway dysfunction in a range of disorders, including psychiatric disorders (i.e., substance-use disorders, affective disorders, eating disorders, and obsessive compulsive disorders), neurodevelopmental disorders (i.e., schizophrenia, attention-deficit/hyperactivity disorder, autism spectrum disorders, Tourette’s syndrome, conduct disorder/oppositional defiant disorder), and genetic syndromes (i.e., Fragile X syndrome, Prader–Willi syndrome, Williams syndrome, Angelman syndrome, and Rett syndrome). We also provide brief overviews of effective psychopharmacologic agents that have an effect on the dopamine system in these disorders. This review concludes with methodological considerations for future research designed to more clearly probe reward-circuitry dysfunction, with the ultimate goal of improved intervention strategies.

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Section: Reviewmentioning

confidence: 99%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

254

207

View full text Add to dashboard Cite

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“…Several brain imaging studies have investigated D-amphetamine (D-AMPH)-induced dopamine (DA) release in the striatum (Laruelle et al, 1995;Kegeles et al, 1999;Drevets et al, 2001;Singer et al, 2002;Piccini et al, 2003;Martinez et al, 2003;Volkow et al, 1994Volkow et al, , 2004. However, dopaminergic neurotransmission in cortex, thalamus, and limbic regions is believed to be significantly involved in psychosis, cognitive function, and psychostimulant drug abuse (Weinberger et al, 2001;Stevens, 1991;Kerwin and Murray, 1992;Goldman-Rakic, 1998;Yasuno et al, 2004;Koob and Le Moal, 2001).…”

Section: Introductionmentioning

confidence: 99%

Amphetamine-Induced Displacement of [18F] Fallypride in Striatum and Extrastriatal Regions in Humans

Riccardi

Ansari

et al. 2005

Neuropsychopharmacol

125

112

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This study examined D-amphetamine (D-AMPH)-induced displacements of [18 F] fallypride in striatal and extrastriatal regions and the correlations of these displacements with cognition, affect, and sensation-seeking behavior. In all, 14 normal subjects, six females and eight males (ages 21-32, mean age 25.9 years), underwent positron emission tomography (PET) with [18 F]fallypride before and 3 h after a 0.43 mg/kg oral dose of D-AMPH. Levels of dopamine (DA) D 2 receptor density were calculated with the reference region method of Lammerstma. Percent displacements in striatal and extrastriatal regions were calculated for the caudate, putamen, ventral striatum, medial thalamus, amygdala, substantia nigra, and temporal cortex. Correlations of changes in cognition, affect, and sensation seeking with parametric images of D-AMPH-induced DA release were computed. Significant displacements were seen in the caudate, putamen, ventral striatum substantia nigra, and temporal cortex with a trend level change in the amygdala. Greatest displacements were seen in striatal subdivisionsF5.6% in caudate, 11.2% in putamen, 7.2% in ventral striatum, and 6.6% in substantia nigra. Lesser decrements were seen in amygdalaF4.4%, temporal cortexF3.7%, and thalamusF2.8%. Significant clusters of correlations of regional DA release with cognition and sensation-seeking behavior were observed. The current study demonstrates that [ 18 F]fallypride PET studies using oral D-AMPH (0.43 mg/kg) can be used to study D-AMPH-induced DA release in the striatal and extrastriatal regions in humans, and their relationship with cognition and sensation-seeking behavior.

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“…Drugs that reduce dopamine activity, such as chlorapromazine and holoperidol (30), also reduce movements. In contrast, increased dopamine activity occurs in Tourette's syndrome (31), marked by fast, hyperkinetic movements, and early stages of Huntington's disease (32), characterized by choreiform movements.…”

Section: Discussionmentioning

confidence: 91%

Conservation law for self-paced movements

Huh

Sejnowski

2016

Proc. Natl. Acad. Sci. U.S.A.

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Optimal control models of biological movements introduce external task factors to specify the pace of movements. Here, we present the dual to the principle of optimality based on a conserved quantity, called “drive,” that represents the influence of internal motivation level on movement pace. Optimal control and drive conservation provide equivalent descriptions for the regularities observed within individual movements. For regularities across movements, drive conservation predicts a previously unidentified scaling law between the overall size and speed of various self-paced hand movements in the absence of any external tasks, which we confirmed with psychophysical experiments. Drive can be interpreted as a high-level control variable that sets the overall pace of movements and may be represented in the brain as the tonic levels of neuromodulators that control the level of internal motivation, thus providing insights into how internal states affect biological motor control.

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Elevated Intrasynaptic Dopamine Release in Tourette’s Syndrome Measured by PET

Abstract: Greater putamen dopamine release was seen in adults with Tourette's syndrome than in comparison subjects after a pharmacologic challenge with amphetamine. These results suggest that the underlying pathobiology in Tourette's syndrome is a phasic dysfunction of dopamine transmission.

Cited by 243 publications

References 49 publications

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Amphetamine-Induced Displacement of [18F] Fallypride in Striatum and Extrastriatal Regions in Humans

Conservation law for self-paced movements

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