Elevated Levels of Carbonyl Proteins in Cerebrospinal Fluid of Patients with Neurodegenerative Diseases

Greilberger, Joachim; Salhofer‐Polanyi, Sabine; Auff, Eduard; Leutmezer, Fritz; Herwig, Ralf

doi:10.1620/tjem.234.313

Cited by 19 publications

(19 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, we reported about the important role of oxidative stress in neurodegenerative diseases [21][22][23] the potential anti-inflammatory modulation of their progress [24]. We aimed to investigate oxidative stress biomarkers in this ALS patient during Vit D therapy because ALS is associated with SOD1 mutation and therefore higher oxidative and nitrosative modifications of neuronal cells.…”

Section: Discussionmentioning

confidence: 99%

Measurement of oxidative stress parameters, vitamin D and vitamin D binding protein during vitamin D treatment in a patient with amyotrophic lateral sclerosis

Greilberger¹,

Greilberger²,

Herwig³

2017

Integr Mol Med

View full text Add to dashboard Cite

Background: Question arises if Amyotrophic lateral sclerosis (ALS, Lou-Gehrig-Syndrom, Charcot-disease) is considered to be an autoimmune disorder that affects the nerval filaments of α-motoneurons in the central nervous system (CNS) due to oxidative stress. SOD mutations seem to play a genetic disorder role in glycosylation and oxidative modifications of neuronal filaments. Vitamin D (VitD) and Vitamin D binding protein (VDBP) has potency to act as an immune modulator. The present study was undertaken to examine the effects of a 34-week vitD supplementation of ImmunoD  , a stabilized Vitamin D3 complex, in a patient with ALS on oxidative stress parameters, nitrosative stress parameter, VitD status and VDBP.

show abstract

Section: Discussionmentioning

confidence: 99%

Measurement of oxidative stress parameters, vitamin D and vitamin D binding protein during vitamin D treatment in a patient with amyotrophic lateral sclerosis

Greilberger¹,

Greilberger²,

Herwig³

2017

Integr Mol Med

View full text Add to dashboard Cite

show abstract

“…CPs are markers for oxidative stress, and they have been assessed in patients with multiple sclerosis and neurodegenerative diseases [13]. Reduced oxidative stress may mirror reduced inflammation [13], and improved cognition may be hypothesized.…”

Section: Discussionmentioning

confidence: 99%

“…Reduced oxidative stress may mirror reduced inflammation [13], and improved cognition may be hypothesized. Additionally, significant differences were seen for levels of Kyn and Kyn/Trp between the supplemented and non-supplemented patient groups.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lowered Levels of Carbonyl Proteins after Vitamin B Supplementation in Patients with Mild Cognitive Impairment and Alzheimer's Disease

Fuchs¹,

Leblhuber²,

Schroth³

et al. 2015

Neurodegener Dis

Self Cite

View full text Add to dashboard Cite

Background: The critical role of neuro-inflammation and oxidative stress in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD) has become evident. Objective: The aim of this study is to assess the influence of vitamin supplementation on parameters of oxidative stress, inflammation as well as on cognition in patients with AD and mild cognitive impairment. Methods: In our study, patients with cognitive impairment and healthy controls were enrolled. All patients were intended to receive vitamin supplementation (vitamin B₁, B₆, B₁₂ and folic acid) for 3 months. Mini Mental State Examination (MMSE) and laboratory markers [carbonyl proteins (CPs), malondialdehyde, tryptophan (Trp), kynurenine (Kyn), neopterin, folic acid, vitamin B₁₂ level] were assessed for patients and controls at baseline and after 3 months. After half of the patients had been treated for 3 months, analyses were performed resulting in 3 subgroups: healthy controls without supplementation (15 subjects, 11 females), patients with vitamin supplementation (17 subjects, 10 females) and patients without vitamin supplementation (16 subjects, 9 females; baseline values prior to supplementation). Results: Age was significantly higher for the supplemented group (76.4 ± 6.7 years) compared to vitamin-naïve patients (63.3 ± 13.7 years; p < 0.01). The MMSE score was higher in the supplemented group (23.1 ± 4.8 vs. 20.3 ± 9.5) but did not reach significance. Levels of CPs were significantly higher in the vitamin-naïve patients (p < 0.05). Levels of Kyn and the Kyn/Trp ratio were significantly lower in vitamin-naïve patients compared to the supplemented group (p < 0.05). No significant difference was seen for the other markers. Conclusion: Vitamin supplementation leads to reduced levels of CPs in patients. Pearson's correlation coefficient shows a negative relation (r = -0.69) between CPs and MMSE. Future trials should assess whether CPs might be suitable markers for monitoring of demented patients.

show abstract

“…One study of protein carbonylation in CSF [83] confirmed higher levels in a mixed MS population compared to controls (p=0.034).…”

Section: End-products Of Oxidation Protein Carbonylationmentioning

confidence: 96%

Oxidative Stress-Related Biomarkers in Multiple Sclerosis: A Review

et al. 2016

View full text Add to dashboard Cite

General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms AbstractObjective: To provide an up to date review of oxidative stress biomarkers in multiple sclerosis and thus identify candidate molecules with greatest promise as biomarkers of diagnosis, disease activity or prognosis.Method: A semi-systematic literature search using PubMed and other databases.Results: Nitric oxide metabolites, superoxide dismutase, catalase, glutathione reductase, inducible nitric oxide synthase, protein carbonyl, 3-nitrotyrosine, isoprostanes, malondialdehyde and products of DNA oxidation have been identified across multiple studies as having promise as diagnostic, therapeutic or prognostic markers in MS.Conclusion: Heterogeneity of study design, particularly patient selection, limits comparability across studies. Further cohort studies are needed, and we would recommend promising markers be incorporated into future clinical trials to prospectively validate their potential.

show abstract

Elevated Levels of Carbonyl Proteins in Cerebrospinal Fluid of Patients with Neurodegenerative Diseases

Cited by 19 publications

References 18 publications

Measurement of oxidative stress parameters, vitamin D and vitamin D binding protein during vitamin D treatment in a patient with amyotrophic lateral sclerosis

Measurement of oxidative stress parameters, vitamin D and vitamin D binding protein during vitamin D treatment in a patient with amyotrophic lateral sclerosis

Lowered Levels of Carbonyl Proteins after Vitamin B Supplementation in Patients with Mild Cognitive Impairment and Alzheimer's Disease

Oxidative Stress-Related Biomarkers in Multiple Sclerosis: A Review

Contact Info

Product

Resources

About