2016
DOI: 10.1111/liv.13174
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Elevated levels of circulating CDH5 and FABP1 in association with human drug‐induced liver injury

Abstract: Background & AimsThe occurrence of drug‐induced liver injury (DILI) is a major issue in all phases of drug development. To identify novel biomarker candidates associated with DILI, we utilised an affinity proteomics strategy, where antibody suspension bead arrays were applied to profile plasma and serum samples from human DILI cases and controls.MethodsAn initial screening was performed using 4594 randomly selected antibodies, representing 3450 human proteins. Resulting candidate proteins together with propose… Show more

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Cited by 30 publications
(29 citation statements)
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“…Proteomics investigations revealed elevated levels of cadherin 5 (CDH5) and fatty acid-binding protein (FABP) as protein biomarkers for DIH (Mikus et al, 2016). However, the detection of idiosyncratic hepatotoxicants with the currently available in vitro methods remains challenging, as idiosyncratic drug reactions are unpredictable and mostly immune mediated (Van Summeren et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…Proteomics investigations revealed elevated levels of cadherin 5 (CDH5) and fatty acid-binding protein (FABP) as protein biomarkers for DIH (Mikus et al, 2016). However, the detection of idiosyncratic hepatotoxicants with the currently available in vitro methods remains challenging, as idiosyncratic drug reactions are unpredictable and mostly immune mediated (Van Summeren et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…• FABP1 has superior characteristics regarding tissue distribution and kinetics compared to ALT. Wu et al, 2016b;Karvellas et al, 2017;Mikus et al, 2017;Wu et al, 2017 CDH5…”
Section: High Mobility Group Box-1 Protein (Hmgb1)mentioning
confidence: 99%
“…(28) Recently, FABP1 has been shown to be a diagnostic marker of liver injury in patients with hepatitis C infection (29) and to be associated with drug-induced liver injury. (30) However, to date FABP1 has not been evaluated as a prognostic marker in these conditions or ALF. FABP1 has physiological properties that could potentially make it advantageous as a prognostic biomarker.…”
Section: Comparison With the Literaturementioning
confidence: 99%