Elevated levels of leukotriene B4 and thromboxane B2 distinguish chest pain of cardiac and non cardiac origin

John, Febi; Kavitha, S.; Panicker, Seema; Nair, Tiny; Indira, M.

doi:10.1016/j.ihj.2013.04.012

Cited by 4 publications

(2 citation statements)

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“…Leukotrienes are important multifunctional mediators of inflammation and promote neutrophil chemotaxis and adherence to capillary walls [ 48 ]. LTB4 is expressed on leucocytes after myocardial IRI [ 36 ], gets elevated in plasma in the course of myocardial infarction [ 42 ] and has been shown to be able to discriminate between cardiac and non-cardiac chest pain [ 26 ]. Coversin has an internal binding pocket capturing LTB4 and C5-inhibition prevents LTB4 formation [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function

et al. 2017

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Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no benefit was found in clinical studies. Due to lack of cross-reactivity of clinically used C5 antibodies, different inhibitors were used in animal and clinical studies. Coversin (Ornithodoros moubata complement inhibitor, OmCI) blocks C5 cleavage and binds leukotriene B4 in humans and pigs. We hypothesized that inhibition of C5 before reperfusion will decrease infarct size and improve ventricular function in a porcine model of myocardial infarction. In pigs (Sus scrofa), the left anterior descending coronary artery was occluded (40 min) and reperfused (240 min). Coversin or placebo was infused 20 min after occlusion and throughout reperfusion in 16 blindly randomized pigs. Coversin significantly reduced myocardial infarction in the area at risk by 39% (p = 0.03, triphenyl tetrazolium chloride staining) and by 19% (p = 0.02) using magnetic resonance imaging. The methods correlated significantly (R = 0.92, p < 0.01). Tissue Doppler echocardiography showed increased systolic displacement (31%, p < 0.01) and increased systolic velocity (29%, p = 0.01) in coversin treated pigs. Interleukin-1β in myocardial microdialysis fluid was significantly reduced (31%, p < 0.05) and tissue E-selectin expression was significantly reduced (p = 0.01) in the non-infarcted area at risk by coversin treatment. Coversin ablated plasma C5 activation throughout the reperfusion period and decreased myocardial C5b-9 deposition, while neither plasma nor myocardial LTB4 were significantly reduced. Coversin substantially reduced the size of infarction, improved ventricular function, and attenuated interleukin-1β and E-selectin in this porcine model by inhibiting C5. We conclude that inhibition of C5 in myocardial infarction should be reconsidered.Electronic supplementary materialThe online version of this article (doi:10.1007/s00395-017-0610-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function

et al. 2017

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“…When measured within the first 24 hours of MI it was elevated also when compared with UA, stable CAD and non-CAD patients. In two studies the level of LTB 4 , when measured in blood among patients with MI was more than double of that in healthy controls [21,22]. It was also shown that LTB 4 can be released by ionomycin in the blood more in the group of patients with a history of MI than in healthy people [23].…”

Section: Acute Coronary Syndromementioning

confidence: 99%

Leukotrienes in the atherosclerotic cardiovascular diseases — a systematic review

et al. 2022

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Introduction:The role of inflammation in the pathogenesis of atherosclerotic diseases is strongly suggested. There are multiple studies indicating the possibility of a pathophysiological connection between atherosclerotic changes and leukotrienes (LTs) -the products of arachidonic acid metabolism. The goal of this systematic review, performed in line with the PRISMA statement, was to investigate the potential role of LTs in the pathophysiology of atherosclerotic cardiovascular diseases (CVD). Material and methods: The MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews were searched to identify the potentially eligible studies. Publications that contained information on any type of LTs identified in blood or urine were included in the review. A database search identified 2082 records. Reliable LTs identification in patients with CVD was used in 30 publications. Results: Stable and acute forms of coronary artery disease are characterized by the overproduction of different types of LTs. The level of LTB 4 and LTC 4 in the blood is elevated in patients with cerebral ischemia. Patients with acute and chronic peripheral artery disease have elevated levels of LTE 4 in urine. Conclusions: The findings of this systematic review show that there is a clear tendency to indicate the association of cardiovascular atherosclerotic diseases with increased production of LTs. This dependency detailed characteristic remains unclear and the question on the impact of elevated leukotrienes on clinical atherosclerotic disease manifestations is still open.

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Obesity and laboratory aspirin resistance in high-risk pregnant women treated with low-dose aspirin

Finneran

Gonzalez-Brown

Smith

et al. 2019

American Journal of Obstetrics and Gynecology

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Elevated levels of leukotriene B4 and thromboxane B2 distinguish chest pain of cardiac and non cardiac origin

Abstract: The measurement of LTB4 and TXB2 levels may therefore be useful to distinguish the chest pain leading to MI from that of non cardiac in origin and for the management of the disease.

Cited by 4 publications

References 20 publications

Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function

Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function

Leukotrienes in the atherosclerotic cardiovascular diseases — a systematic review

Obesity and laboratory aspirin resistance in high-risk pregnant women treated with low-dose aspirin

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