Elevated Levels of N-Terminal Pro-Brain Natriuretic Peptide in Patients with Chronic Dyspnea and Moderate Renal Dysfunction: Decreased Clearance or Increased Cardiac Stress

Wieshammer, Siegfried; Dreyhaupt, Jens; Basler, Beate

doi:10.1159/000329537

Cited by 4 publications

(1 citation statement)

References 48 publications

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“…Findings of the present study were not consistent with a passive accumulation of NT‐proBNP in this group of dogs with CKD. Although it was previously thought that increased NT‐proBNP concentrations in humans with CKD result from decreased renal clearance of NT‐proBNP, recent reports suggest that the main reason is increased secretion of this peptide by the heart . Measurement of NT‐proBNP and its metabolites in urine from people with CHF and differing kidney function shows that urine excretion of NT‐proBNP increases rather than decreases with decreasing eGFR .…”

Section: Discussionmentioning

confidence: 99%

Cardiac Troponin I and Amino‐Terminal Pro B‐Type Natriuretic Peptide in Dogs With Stable Chronic Kidney Disease

Pelander

Häggström

Ley

et al. 2017

Veterinary Internal Medicne

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BackgroundIncreased concentrations of N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) and cardiac troponin I (cTnI) in dogs with azotemia have been documented. Knowledge of mechanisms behind increased concentrations of cardiac biomarkers in dogs with azotemia is warranted for correct interpretation of test results.ObjectivesThe aim of the article was to investigate possible associations between plasma concentrations of cTnI and NT‐proBNP, respectively, and patient characteristics, glomerular filtration rate (GFR), a plasma volume factor (PVF) derived from scintigraphic examination (PVf), systolic blood pressure (SBP), selected hematologic and biochemical variables, and echocardiographic measurements in dogs with stable chronic kidney disease (CKD) and in healthy dogs.AnimalsFifty student‐, staff‐, and client‐owned dogs were included. Twenty‐three of the dogs were healthy and 27 were diagnosed with CKD.MethodsIn this cross‐sectional observational study, dogs with a previous diagnosis of CKD and healthy control dogs were included. At inclusion, all dogs were characterized by physical examination, repeated blood pressure measurements, complete urinalysis, hematology and biochemistry panel, echocardiography, abdominal ultrasound examination of the entire urinary tract, and scintigraphic examination for measurement of GFR.ResultsPlasma volume factor and PCV were independently associated with NT‐proBNP (Radj2 = 0.42; P < .0001). Age, body weight (BW), and SBP were independently associated with cTnI (Radj2 = 0.50; P < .0001).Conclusions and Clinical ImportanceNeither NT‐proBNP nor cTnI concentrations were independently associated with measured GFR. Thus, findings were not suggestive of passive accumulation of either marker, suggesting that increased circulating concentrations of cTnI and NT‐proBNP can be interpreted similarly in dogs with stable CKD as in dogs without CKD.

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Section: Discussionmentioning

confidence: 99%

Cardiac Troponin I and Amino‐Terminal Pro B‐Type Natriuretic Peptide in Dogs With Stable Chronic Kidney Disease

Pelander

Häggström

Ley

et al. 2017

Veterinary Internal Medicne

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Serum 25-hydroxyvitamin D and parathyroid hormone in relation to plasma B-type natriuretic peptide: the Hoorn Study

Ballegooijen¹,

Visser²,

Snijder³

et al. 2012

Endocrine Connections

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ObjectiveA disturbed vitamin D–parathyroid hormone (PTH)–calcium axis may play a role in the pathogenesis of heart failure. Therefore, we investigated whether lower 25-hydroxyvitamin D (25(OH)D) and higher PTH are cross sectionally and after 8 years of follow-up associated with higher B-type natriuretic peptide (BNP) levels in older men and women.Design and methodsWe measured baseline 25(OH)D, PTH, and BNP in 502 subjects in 2000–2001 in the Hoorn Study, a population-based cohort. Follow-up BNP was available in 2007–2009 in 278 subjects. Subjects were categorized according to season- and sex-specific quartiles of 25(OH)D and PTH at baseline. We studied the association of 25(OH)D and PTH quartiles with BNP using linear regression analyses adjusting for confounders. Analyses were stratified by kidney function estimated glomerular filtration rate (eGFR; ≤60 ml/min per 1.73 m2) because of significant interaction.ResultsAt baseline, subjects had a mean age of 69.9±6.6 years, mean 25(OH)D level was 52.2±19.5 nmol/l and mean PTH 6.1±2.4 pmol/l. Cross sectionally, 25(OH)D was associated with BNP in subjects with impaired kidney function (eGFR ≤60 ml/min) only. The association attenuated after adjustment for PTH. PTH was cross sectionally associated with BNP, also in subjects with impaired kidney function only: regression coefficient of highest quartile 9.9 pmol/l (95% confidence interval 2.5, 17.4) with a significant trend across quartiles. Neither 25(OH)D nor PTH was associated with BNP in longitudinal analyses.ConclusionThis study showed overall no strong association between 25(OH)D and BNP. However, PTH was associated with BNP in subjects with impaired kidney function and may point to a potential role in myocardial function.

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Clinical usefulness of an assay for measurement of circulating N-terminal pro-B-type natriuretic peptide concentration in dogs and cats with heart disease

Oyama

Boswood²,

Connolly³

et al. 2013

javma

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Elevated Levels of N-Terminal Pro-Brain Natriuretic Peptide in Patients with Chronic Dyspnea and Moderate Renal Dysfunction: Decreased Clearance or Increased Cardiac Stress

Cited by 4 publications

References 48 publications

Cardiac Troponin I and Amino‐Terminal Pro B‐Type Natriuretic Peptide in Dogs With Stable Chronic Kidney Disease

Cardiac Troponin I and Amino‐Terminal Pro B‐Type Natriuretic Peptide in Dogs With Stable Chronic Kidney Disease

Serum 25-hydroxyvitamin D and parathyroid hormone in relation to plasma B-type natriuretic peptide: the Hoorn Study

Clinical usefulness of an assay for measurement of circulating N-terminal pro-B-type natriuretic peptide concentration in dogs and cats with heart disease

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