Elevated levels of preβ1-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease

Abstract

BackgroundPreβ1-high-density lipoprotein (preβ1-HDL), plays an important role in reverse cholesterol transport and exhibits potent risk for coronary artery disease (CAD). However, the association of plasma preβ1-HDL and cholesterol ester transfer protein (CETP) levels in CAD patients and the relationship of preβ1-HDL with extent of CAD are debatable.MethodsPreβ1-HDL and CETP levels were measured by enzymed-linked immunosorbent assay (ELISAs) in 88 acute coronary syndromes (ACS), 79 stable coronary artery disease (SCAD) patients and 85 control subjects. The correlation analyses, multiple linear regression analyses and logistic regression analyses were performed, respectively.ResultsThe preβ1-HDL and CETP levels in ACS patients were significantly higher than those in SCAD patients and both of them were higher than controls’. Preβ1-HDL levels were positively associated with CETP (R = 0.348, P = 0.000), the diameter of stenosis (R = 0.253, P = 0.005), the number of vessel disease (R = 0.274, P = 0.002) and Gensini score (R = 0.227, P = 0.009) in CAD patients. Stepwise multiple linear regression analyses showed that CETP was one of the determinants of preβ1-HDL levels. Logistic regression analysis revealed that elevated preβ1-HDL and CETP were potential risk factors for both ACS and SCAD.ConclusionThe elevated preβ1-HDL levels may change with CETP concentrations in CAD patients and were related to the presence and severity of CAD.

Plasma Levels of Preβ1-HDL Are Significantly Elevated in Non-Dialyzed Patients with Advanced Stages of Chronic Kidney Disease

“…CKD is an independent cardiovascular risk factor, and the gradual decrease of eGFR in CKD patients translates into a linear increase of cardiovascular disease (CVD) mortality [18]. A number of clinical studies showed the increase of preβ1-HDL in patients with coronary artery disease, confirming the associations between increased levels of pre-preβ1-HDL and the risk of CAD, and proposed that high levels of preβ1-HDL remained a significant predictor of CVD even after adjustment for traditional risk factors [19,20,21]. Despite such an integrating role of the smallest HDL fraction in the atherosclerosis, the data about preβ1-HDL in non-dialysis patients with CKD are poor.…”

The Role and Function of HDL in Patients with Chronic Kidney Disease and the Risk of Cardiovascular Disease

“…Kuchta et al [125] demonstrated that, in CKD patients with stages 3a-4, the concentration of preβ1-HDL was increased. Elevated concentrations of preβ1-HDL have been also observed in patients with coronary artery disease, which suggests the relationship between higher levels of preβ1-HDL and the risk of CVD [126,127]. Kuchta et al [125] reported a substantial increase of preβ1-HDL in patients with 3a-4 stages of CKD, which was probably associated with a compromised LCAT-dependent conversion of preβ1-HDL into α-migrating HDL.…”

Paraoxonase 1 and atherosclerosis‐related diseases

“…servier.com) the first step of the RCT process. 14 However, their level is increased in patients with CVD 45 and CRD, 46 indicating altered HDL maturation, increased production, or delayed catabolism of small HDL particles, which is particularly relevant in CRD. 24 In our study, PON1 activity gradually decreased with progression of CRD toward ESRD, 43,44 while Kuchta and colleagues 44 further demonstrated that patients with stages 3 and 4 CRD had similar PON1 activities.…”