2020
DOI: 10.1038/s41598-020-62541-7
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Elevated levels of proinflammatory volatile metabolites in feces of high fat diet fed KK-Ay mice

Abstract: When the microfloral composition deteriorates, it triggers low-level chronic inflammation associated with several lifestyle-related diseases including obesity and diabetic mellitus. Fecal volatile organic compounds (VOCs) have been found to differ in gastrointestinal diseases as well as intestinal infection. In this study, to evaluate a potential association between the pathogenesis of lifestyle-related diseases and VOCs in the intestinal tract, fecal VOCs from obese/diabetic KK-A y mice (KK) or controls (C57B… Show more

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Cited by 13 publications
(9 citation statements)
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“…Aldehydes and fatty alcohol are extensively found in different fruits and plants and are responsible for the aroma of plant EO, a better smeller, but also the antiinflammatory activity (Foudah et al, 2021;Heidari et al, 2016). Fr-GEO used in the present study was enriched in aldehydes such as octanal, nonanal, citronellal, and undecanal noted by their anti-inflammatory effects (Choi et al, 2020;Foudah et al, 2021;Uchikawa et al, 2020;Xiao et al, 2017). Results from different animal models suggest citral to be used as a supporting anti-inflammatory agent reporting its potentially promising, safe, and innovative use (Campos et al, 2019;Oliveira et al, 2021;Shi et al, 2020), including EOs that have citral as their main component (Han & Parker, 2017;Martins et al, 2017).…”
Section: Discussionmentioning
confidence: 81%
See 1 more Smart Citation
“…Aldehydes and fatty alcohol are extensively found in different fruits and plants and are responsible for the aroma of plant EO, a better smeller, but also the antiinflammatory activity (Foudah et al, 2021;Heidari et al, 2016). Fr-GEO used in the present study was enriched in aldehydes such as octanal, nonanal, citronellal, and undecanal noted by their anti-inflammatory effects (Choi et al, 2020;Foudah et al, 2021;Uchikawa et al, 2020;Xiao et al, 2017). Results from different animal models suggest citral to be used as a supporting anti-inflammatory agent reporting its potentially promising, safe, and innovative use (Campos et al, 2019;Oliveira et al, 2021;Shi et al, 2020), including EOs that have citral as their main component (Han & Parker, 2017;Martins et al, 2017).…”
Section: Discussionmentioning
confidence: 81%
“…Aldehydes and fatty alcohol are extensively found in different fruits and plants and are responsible for the aroma of plant EO, a better smeller, but also the anti‐inflammatory activity (Foudah et al., 2021; Heidari et al., 2016). Fr‐GEO used in the present study was enriched in aldehydes such as octanal, nonanal, citronellal, and undecanal noted by their anti‐inflammatory effects (Choi et al., 2020; Foudah et al., 2021; Uchikawa et al., 2020; Xiao et al., 2017).…”
Section: Discussionmentioning
confidence: 97%
“…This lipid aldehyde belongs to n-alkenals and is formed in vivo via host or bacterial metabolism or can be derived from the autoxidation of unsaturated fatty acid. Studies supported the proinflammatory effect of this lipid aldehyde classified as n-alkenals through tumor necrosis factor α (TNF-α) up-regulation [ 31 ]. In our results, nonanal was positive correlated with IBS-SSS total score in LFD group, suggesting its contribution in low-level induction of chronic inflammation via pro-inflammation cytokines [ 32 ].…”
Section: Discussionmentioning
confidence: 99%
“…LC–MS consisted of a 1290 Infinity II LC System (Agilent, Santa Clara, CA, USA) coupled with a G6410B triple quadrupole mass spectrometer (Agilent). UPLC separation , was carried out with an ethylene bridged hybrid (BEH) C18 column (1.7 μm, 50 mm × 2.1 mm i.d., Waters) at 40 °C using 0.1% of formic acid in water as solvent A and 0.1% of formic acid in MeOH as solvent B. The gradient condition for B % was 0–3 min = 1%, 3.01–10 min = 1–50%, 10.01–12 min = 99%, and 12.01–15 min = 1%.…”
Section: Introductionmentioning
confidence: 99%
“…LC−MS consisted of a 1290 Infinity II LC System (Agilent, Santa Clara, CA, USA) coupled with a G6410B triple quadrupole mass spectrometer (Agilent). UPLC separation 13,14…”
Section: ■ Introductionmentioning
confidence: 99%