Elevated Lipase Without Pancreatitis in Infectious Colitis

Origin, Presentation, and Clinical Course of Nonpancreatic Hyperlipasemia

“…Gut inflammation and obstruction result in the release of lipase from gastrointestinal epithelium. 10,15 Neurologic processes can cause hyperlipasemia via increased cholecystokinin stimulation of pancreatic enzyme release. 7 Intensive care unit patients can develop hyperlipasemia from multiorgan failure and hypoperfusion.…”

“…6 However, serum lipase levels can be elevated in a variety of other disorders. [7][8][9][10][11][12][13][14][15][16][17] Our aim is to define the prevalence and clinical significance of nonpancreatic etiologies for hyperlipasemia in a large prospectively collected cohort of patients.…”

Elevated Lipase during Initial Presentation of Ulcerative Colitis in a Pediatric Patient: Do We Check for It

“…Most of the prior reports of pancreatitis have been in association with CD but there are also a few reports of pancreatitis with ulcerative colitis. Several potential pathophysiological processes have been suggested for hyperlipasemia with or without pancreatitis in IBD [33, 4, 5]. There might be an abnormal passage of pancreatic enzymes from the gut lumen into the blood due to increased permeability of the inflamed mucosa in IBD.…”

“…Another remote possibility is cryptogenic hyperlipasemia without pancreatitis where macrolipase or immunoglobulin-linked enzymes are suggested to be induced by autoimmune mechanisms resulting in reduced glomerular excretion of the large macrolipase molecules thereby increasing serum half-life of lipase [4, 9]. This may not be associated with pancreatic inflammation with no subsequent sequelae of pancreatic insufficiency.…”