Elevated Maternal Folate Status and Changes in Maternal Prolactin, Placental Lactogen and Placental Growth Hormone Following Folic Acid Food Fortification: Evidence from Two Prospective Pregnancy Cohorts

Jankovic‐Karasoulos, Tanja; Smith, Melanie D.; Leemaqz, Shalem; Williamson, Jessica M.; McCullough, Dylan; Arthurs, Anya L.; Jones, Luke; Bogias, Konstantinos Justin; Mol, Ben Willem J.; Dalton, Julia; Dekker, Gustaaf A.; Roberts, Claire T.

doi:10.3390/nu15071553

Cited by 5 publications

(2 citation statements)

References 102 publications

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“…Due to these differences, there are specific dietary recommendations and reference values for pregnant women. For example, the 2012 Nordic Nutrition Recommendations and the 2020-2025 Dietary Guidelines for Americans include specific recommendations for pregnant women (8)(9)(10)(11)(12).…”

Section: Resultsmentioning

confidence: 99%

Risk Factors That Increase Maternal Morbidity in Pregnant Women Between 30 to 34 Years of Age.

L. Villalobos-Rodríguez,

del Carmen Cárdenas-Núñez,

Narváez-Palacios

et al. 2023

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INTRODUCTION.According to the World Health Organization (WHO), the prevalence of obesity worldwide has nearly tripled since 1975. According to 2016 data, 39% of the global adult population was overweight, and 13% was obese. A recent study, including 20 European countries, concluded that 53% of adults were overweight or obese. Increase in overweight and obesity among women of childbearing age (15 to 44 years). Overweight and obesity during pregnancy are associated with many complications, including increased risk of gestational hypertension, preeclampsia, gestational diabetes mellitus, cesarean delivery, preterm delivery, large-for-gestational-age infants, and stillbirths. Additionally, gestational weight gain is associated with diabetes, pregnancy-induced hypertension, cesarean delivery, postpartum weight retention, macrosomia, and childhood obesity. MATERIAL AND METHOD. An observational, cross-sectional study in 15 pregnantwomen in 2022 at the Playa del Carmen General Hospital. RESULTS.Were completed variables of interest in prenatal control.DISCUSSION. The short interval between pregnancies is a public health problem because it leads to adverse perinatal outcomes such as postpartum hemorrhage, anemia, preterm delivery, low birth weight, and perinatal deaths. Ineffective or no contraception after one pregnancy contributes to a subsequent pregnancy. CONCLUSIONS.It is essential to detect gestational Diabetes mellitus as well as gestational hypertension, and prenatal control should be improved because although pregnant women report carrying it out, it is not reflected in cases of preeclampsia that remains high in pregnant women.

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Section: Resultsmentioning

confidence: 99%

Risk Factors That Increase Maternal Morbidity in Pregnant Women Between 30 to 34 Years of Age.

L. Villalobos-Rodríguez,

del Carmen Cárdenas-Núñez,

Narváez-Palacios

et al. 2023

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“…However, the study did not observe any specific dose or duration-related associations between folic acid supplementation and the risk of GDM. Notably, two prospective pregnancy cohorts performed in Australia investigating the impact of folic acid fortification unveiled changes in hormonal profiles, raising concerns regarding the appropriateness of folic acid supplementation and the potential risks related to insulin resistance and gestational diabetes in specific populations [5]. These results highlight the complexities in understanding the relationship between folic acid supplementation and GDM risk.…”

mentioning

confidence: 99%

Nutrition and Supplements during Pregnancy: A Vital Component in Building the Health and Well-Being of Both the Mother and the Developing Baby

Qin,

Xie

2023

Nutrients

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The association of metabolic profile of folate with diabetic kidney disease: evidence from 2011–2020 cycles of the NHANES

Liang,

Ding,

Tao

et al. 2024

Renal Failure

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Aims Diabetic kidney disease (DKD) develops in approximately 40% of patients with type 2 diabetes mellitus (T2DM). The role of folate metabolites in the progression from T2DM to DKD has not been clearly articulated. Our aim was to assess the association of folate metabolites with DKD. Methods We conducted a cross-sectional study sourced from the U.S. National Health and Nutrition Examination Survey from 2011 to 2020. Several forms of folate were measured. DKD was defined as diabetes with albuminuria or impaired glomerular filtration rate. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression. Results Of the 3,461 diabetes patients, 1,349 (38.98%) were diagnosed with DKD. Serum total folate and 5-Methyl-THF were negatively associated with DKD, the OR for comparing extreme quintile were both 0.73 (0.57–0.94). However, a positive association of RBC folate, UMFA, Non-5-Methyl-THF, and MeFox with DKD was observed with extreme quintile OR of 1.41 (1.10–1.82), 1.60 (1.24–2.07), 1.53 (1.20–1.96), and 3.45 (2.65–4.50). Furthermore, the ratio of UMFA to 5-Methyl-THF exhibited a positive association with DKD, with extreme quintile OR of 1.94 (1.50–2.50). Conclusions Our findings suggested that guidelines and interventions highlighting the importance of promoting 5-Methyl-THF and reducing UMFA might have significant benefit for the management of patients with diabetes.

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Elevated Maternal Folate Status and Changes in Maternal Prolactin, Placental Lactogen and Placental Growth Hormone Following Folic Acid Food Fortification: Evidence from Two Prospective Pregnancy Cohorts

Cited by 5 publications

References 102 publications

Risk Factors That Increase Maternal Morbidity in Pregnant Women Between 30 to 34 Years of Age.

Risk Factors That Increase Maternal Morbidity in Pregnant Women Between 30 to 34 Years of Age.

Nutrition and Supplements during Pregnancy: A Vital Component in Building the Health and Well-Being of Both the Mother and the Developing Baby

The association of metabolic profile of folate with diabetic kidney disease: evidence from 2011–2020 cycles of the NHANES

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