Elevated peripheral absolute monocyte count related to clinicopathological features and poor prognosis in solid tumors: Systematic review, meta‐analysis, and meta‐regression

Wen, Shu; Chen, Nan; Hu, Ying; Huang, Lingli; Jin, Peng; Yang, Meng‐Yin; Shen, Xiaoyang; Song, Yang; Xu, Liangzhi

doi:10.1002/cam4.3773

Cited by 15 publications

(8 citation statements)

References 199 publications

(240 reference statements)

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“…Bold P values represented that corresponding covariates could significantly reduce the heterogeneity through meta-regressions or subgroup analyses. The format of this table reference another table from the study by Wen et al50 CI indicates confidence interval; OR, odds ratio; P, P-value of WMD; Ph, P-value of heterogeneity test; WMD, weighted mean difference.…”

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confidence: 99%

The Relationship Between Colorectal Polyps and Serum Lipid Levels

Zhang

Yin

Huo

et al. 2022

Journal of Clinical Gastroenterology

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Colorectal polyp has been considered as the precancerous lesion of colorectal cancer, to which serum lipid levels are closely related. At present, there is no consensus on the relationship between colorectal polyps and serum lipid levels. We performed a meta-analysis to explore the effects of lipid levels on colorectal polyps. Relevant articles published from 2000 to 2020 were searched in PubMed, Web of Science, EMBASE, and Cochrane Library databases. The mean value and SD of serum lipid indexes and body mass index in colorectal polyps groups and control groups were extracted from the included articles. Combined weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated to assess the effect size of serum lipid levels on colorectal polyps. The publication bias of the included studies were assessed based on the Egger test. Thirty-seven articles containing 19,464 cases and 63,979 controls were included. There were no significant publication bias. The levels of high-density lipoprotein cholesterol in the cases were lower than those in the controls (WMD: −2.589 mg/dL, 95% CI: −3.273, −1.906). While the levels of triglyceride (WMD: 16.933 mg/dL, 95% CI: 13.131, 20.736), total cholesterol (WMD: 5.561 mg/dL, 95% CI: 3.477, 7.645), low-density lipoprotein cholesterol (WMD: 3.109 mg/dL, 95% CI: 0.859, 5.359) and body mass index (WMD: 0.747 mg/dL, 95% CI: 0.588, 0.906) were higher in the cases. Colorectal polyps were associated with serum lipid levels and obesity. Hyperlipidemia and obesity may be the risk factors for colorectal polyps.

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confidence: 99%

The Relationship Between Colorectal Polyps and Serum Lipid Levels

Zhang

Yin

Huo

et al. 2022

Journal of Clinical Gastroenterology

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“…In the tumour microenvironment, monocytes can differentiate into tumour-associated macrophages (TAMs), inhibit the adaptive immune response, and participate in tumour growth and metastasis. Higher monocyte levels may indicate poorer prognosis [ 30 ]. Therefore, the SIRI, as an index representing three cell counts, can play a predictive role in the poor prognosis of patients with malignant tumours [ 31 ].…”

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confidence: 99%

Predictive effect of the systemic inflammation response index (SIRI) on the efficacy and prognosis of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

Ding,

Liu,

et al. 2024

BMC Surg

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Background Inflammation is a part of tumours, and inflammatory cells can affect the proliferation, invasion, and development of tumour cells. An increasing number of peripheral blood inflammatory markers have been found to play very important roles in the treatment and prognosis of cancer patients. The systemic inflammatory response index (SIRI) is a newer inflammatory marker, and its role in colorectal cancer, especially in locally advanced rectal cancer, is still unclear. Methods From 2015 to 2020, 198 patients with locally advanced rectal cancer (LARC) who underwent surgery following neoadjuvant chemoradiotherapy (Neo-CRT) were analysed. Patients were categorized into good- and poor- response groups according to their pathological results, and clinical characteristics and baseline parameters were compared between the two groups. The optimal cutoff values for inflammatory indicators were determined using receiver operating characteristic (ROC) analysis. Univariate and multivariate analyses were performed using the Cox proportional hazard model. Survival analysis was performed via the Kaplan‒Meier method. Results After patients were grouped into good and poor response groups, indicator differences were found in CEA, neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and SIRI. According to the ROC analysis, the NLR (P = 0.015), SII (P = 0.001), and SIRI (P = 0.029) were significant prognostic factors. After univariate and multivariate analyses of the Cox proportional hazards regression model, only the SIRI was found to be an independent prognostic factor for overall survival (OS) and disease-free survival (DFS). Finally, Kaplan‒Meier survival curves also confirmed the ability of the SIRI to predict survival. Conclusion The preoperative SIRI can be used to predict the response to Neo-CRT in LARC patients and is an independent predictor of OS and DFS in postoperative patients. A high SIRI was associated with poor radiotherapy response and predicted poor OS and DFS.

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“…In the tumor microenvironment, monocytes can differentiate into tumor-associated macrophages (TAMs), inhibit the adaptive immune response, and participate in tumor growth and metastasis. Higher monocyte levels may indicate poorer prognosis [30] . Therefore, SIRI, as an index calculated by three cell counts, can play a predictive role in the poor prognosis of malignant tumors [31] .…”

Section: Discussionmentioning

confidence: 99%

Predictive effect of the systemic inflammation response index (SIRI) on the efficacy and prognosis of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

Ding,

Liu,

et al. 2023

Preprint

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Background Inflammation is a part of tumors, in which inflammatory cells can affect the proliferation, invasion, and development of tumor cells. More and more An increasing number of peripheral blood inflammatory markers have been found to play very important roles in the treatment and prognosis of cancer patients. The systemic inflammation response index (SIRI) is a newer inflammatory marker, and its role in colorectal cancer, especially in locally advanced rectal cancer, is still unclear. Methods From 2015 to 2020, 198 patients with locally advanced rectal cancer (LARC) who underwent surgery following neoadjuvant chemoradiotherapy (Neo-CRT) were analyzed. Patients were categorized into good and poor response groups according to their pathological results, and clinical characteristics and baseline parameters were compared between the two groups. The optimal cutoff values of inflammatory indicators were determined using receiver operating characteristic (ROC) analysis. Univariate analysis and multivariate analysis were performed using the Cox proportional hazard model. Survival analysis was calculated by the Kaplan‒Meier method. Result After the patients were grouped by good and poor responses, it was found that there were differences among the four indicators of CEA, neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and SIRI. In the ROC analysis, the NLR (P = 0.015), SII (P = 0.001), and SIRI (P = 0.029) were found to be significant prognostic factors. After univariate and multivariate analyses of the Cox proportional hazards regression model, only SIRI was found to be an independent prognostic factor for overall survival (OS) and disease-free survival (DFS). Finally, the Kaplan‒Meier survival curve also confirmed the predictive effect of SIRI on survival. Conclusion Preoperative SIRI can predict the response to Neo-CRT in patients with LARC and is an independent predictor of OS and DFS in postoperative patients. High SIRI was associated with poor radiotherapy response and predicted poor OS and DFS.

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Elevated peripheral absolute monocyte count related to clinicopathological features and poor prognosis in solid tumors: Systematic review, meta‐analysis, and meta‐regression

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 15 publications

References 199 publications

The Relationship Between Colorectal Polyps and Serum Lipid Levels

The Relationship Between Colorectal Polyps and Serum Lipid Levels

Predictive effect of the systemic inflammation response index (SIRI) on the efficacy and prognosis of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

Predictive effect of the systemic inflammation response index (SIRI) on the efficacy and prognosis of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

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