Elevated PGI2 And PGE2 Production in the Rat Ileum following Mild Hypotension

Myers, Stuart I.; Parks, Lori; Smith, Gregory; Miller, Thomas A.

doi:10.1097/00005373-198808000-00011

Cited by 16 publications

(4 citation statements)

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“…Although it remains to be determined whether there is any cause and effect relationship between the upregulated PGE 2 production and the depressed hepatocellular function following chemically induced hypotension, studies have indicated that PGE 2 production increased significantly after hemorrhage and hypotension [31][32][33]. In addition, the gastrointestinal tract may serve as a source for the elevated PGE 2 in various models of shock and hypotension [31].…”

Section: Discussionmentioning

confidence: 99%

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Hepatocellular Dysfunction after Severe Hypotension in the Absence of Blood Loss Is Associated with the Increased IL-6 and PGE2

Wang

Cioffi

et al. 1998

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

“…In addition, the gastrointestinal tract may serve as a source for the elevated PGE 2 in various models of shock and hypotension [31]. Studies have shown that inhibition of PGE 2 production by ibuprofen prevented the depression of macrophage function following hemorrhagic shock [33].…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular Dysfunction after Severe Hypotension in the Absence of Blood Loss Is Associated with the Increased IL-6 and PGE2

Wang

Cioffi

et al. 1998

Journal of Surgical Research

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“…Prostanoids are paracrine substances that are produced by the entire gastrointestinal tract, including the gall-bladder [6,21,25]. Previous studies in vitro have shown that PGI2 decreased gallbladder normal fluid absorption when applied exogenously to rabbit gall-bladder [8].…”

Section: Discussionmentioning

confidence: 99%

“…The method of preparation ofmicrosomal membrane fractions has been described for several different tissues (our laboratory and others), including kidney, arteries, brain, gastrointestinal tract and gall-bladder [6,[21][22][23][24][25][26][27]. Harvested gall-bladders from control and BDL groups were weighed and added to 3 vol.…”

Section: Preparation Of Microsomal Membrane Fractionsmentioning

confidence: 99%

Increased gall-bladder prostanoid synthesis after bile-duct ligation in the rabbit is secondary to new enzyme formation

Myers

Evans

Bartula

et al. 1992

Biochemical Journal

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Ligation of the common bile duct (BDL) in the male rabbit resulted in increased gall-bladder microsomal total cyclo-oxygenase activity with prostaglandin E2 (PGE2) and 6-oxoprostaglandin F1 alpha [6-oxo-PGF1 alpha, stable metabolite of prostaglandin I2 (PGI2; prostacyclin)] as the major prostanoids synthesized after 24 and 72 h. Kinetic analysis of gallbladder microsomal membrane fractions incubated with increasing levels of [14C]arachidonic acid indicated that BDL for 24 and 72 h did not change substrate affinity (apparent Km) but markedly increased the rate of conversion (apparent Vmax.) suggesting the presence of more total enzyme responsible for synthesis of 6-oxo-PGF1 alpha and PGE2. BDL for 24 and 72 h significantly increased gall-bladder tissue slice basal release of 6-oxo-PGF1 alpha, but not PGE2, when compared with the controls. Gall-bladder slice release of PGE2 was 3-fold less than 6-oxo-PGF1 alpha in the control gall-bladder slices. Immunoblot analysis of 72 h BDL gall-bladder microsomal membrane fractions showed a slight increase in cyclo-oxygenase content and a 5-fold increase in the content of prostacyclin synthase as compared with the control. These data suggest that the BDL-stimulated total gall-bladder cyclo-oxygenase activity was the result of an increase in the level of specific prostaglandin-synthetic enzymes, in particular prostacyclin synthase, and not from a change in enzyme affinity.

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Development of a severe mesenteric traction syndrome during major abdominal surgery is associated with increased postoperative morbidity: Secondary data analysis on prospective cohorts

Olsen

Strandby

Nerup

et al. 2019

Langenbecks Arch Surg

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Elevated PGI2 And PGE2 Production in the Rat Ileum following Mild Hypotension

Cited by 16 publications

References 0 publications

Hepatocellular Dysfunction after Severe Hypotension in the Absence of Blood Loss Is Associated with the Increased IL-6 and PGE2

Hepatocellular Dysfunction after Severe Hypotension in the Absence of Blood Loss Is Associated with the Increased IL-6 and PGE2

Increased gall-bladder prostanoid synthesis after bile-duct ligation in the rabbit is secondary to new enzyme formation

Development of a severe mesenteric traction syndrome during major abdominal surgery is associated with increased postoperative morbidity: Secondary data analysis on prospective cohorts

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