Elevated Plasma Adiponectin Levels Are Associated with Abnormal Corrected QT Interval in Patients with Stable Angina

Abstract

Low-circulating levels of adiponectin (ADPN) are associated with obesity, diabetes mellitus, and coronary artery disease. On the contrary, some studies have demonstrated a link between relatively high levels of plasma ADPN and heart failure, atrial fibrillation, and adverse outcome. However, little is known about the relationship between ADPN level and prolonged QT interval. The aim of this study was to investigate the association between plasma ADPN levels and prolonged QT interval in patients with stable angina. In this retrospective study, because the diverse disease severity and condition of the study population may have affected the results, we chose individuals with stable angina. Plasma ADPN concentrations were measured using enzyme-linked immunosorbent assays. A 12-lead ECG recording was obtained from each patient. We enrolled 479 stable-angina patients. Patients with an abnormal corrected QT (QTc) interval had higher median plasma ADPN levels than those with normal QTc intervals. Age-and sex-adjusted ADPN levels were positively associated with heart rate, QTc interval, left ventricular mass index, and creatinine but negatively associated with left ventricular ejection fraction, waist circumference, current smoking, total cholesterol, triglycerides, low-density lipoprotein cholesterol, albumin, and estimated glomerular filtration rate. A multiple logistic regression analysis revealed ADPN as an independent association factor for abnormal QTc interval. Increasing concentrations of sex-specific ADPN were independently and significantly associated with abnormal QTc interval, even after full adjustment of known biomarkers. Our results indicate that ADPN may play a role in the pathogenesis of abnormal QTc interval in patients with stable angina.

Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina

“…Adiponectin and FGF21 both control the metabolism of lipids and carbohydrates, which is essential for the maintenance of energy homeostasis in the body and hence for survival. In one of our previous studies, plasma adiponectin levels have been proved to have the correlation with QTc interval prolongation [67]. A previous study further demonstrated adiponectin could mediates the metabolic effects of FGF21 [66].…”

Increasing Adiposity Is Associated With QTc Interval Prolongation and Increased Ventricular Arrhythmic Risk in the Context of Metabolic Dysfunction: Results From the UK Biobank

“…Serum levels of the adipokine fatty-acid binding protein has also been suggested as a biochemical proxy for prolonged QTc interval and reduced ejection fraction in patients with stable angina ( 19 ). Similarly, plasma adiponectin may modulate ventricular repolarisation and thereby QTc interval ( 20 ). Given that APD prolongation manifests as QTc prolongation on 12-lead ECG, our results are compatible with adipocytokine-mediated modulation of ionic channels.…”

Predictive potential of blood biomarkers for subsequent ventricular tachyarrhythmias in patients with chronic heart failure and reduced left ventricular ejection fraction: review

“…В литературе имеются данные о связи повышенного уровня адипонектина с патологическим удлинением коррегированного интервала QT на электрокардиограмме -признака электрической нестабильности миокарда [54]. В эксперименте был доказан вклад лептина в возникновение и поддержание ишемической ЖТ [55].…”