Elevated plasma lipoprotein(a) levels were associated with increased risk of cardiovascular events in Chinese patients with stable coronary artery disease

Abstract

Recent studies have suggested that lipoprotein(a) [Lp(a)] is associated with cardiovascular disease (CVD). However, the contribution of Lp(a) to residual risk of CVD has not been determined in Chinese populations. We conducted a prospective study to evaluate the association between Lp(a) and the risk of major adverse cardiovascular events (MACEs) in patients with stable coronary artery disease (CAD) who received optimal medication treatment (OMT). The study enrolled 1602 patients with stable CAD from 5 hospitals in China. The baseline clinical characteristics and follow-up MACE data for the patients were recorded. Coronary lesion severity was assessed by the Gensini scoring system. All-cause death, non-fatal myocardial infarction, non-fatal stroke and unplanned coronary revascularization were considered MACEs. We found that plasma Lp(a) levels were positively associated with coronary lesion severity at baseline (p < 0.001). During a mean follow-up period of 39.6 months, 166 (10.4%) patients suffered MACEs. There were significant differences in the adjusted event-free survival rates among the Lp(a) quartile subgroups (p = 0.034). The hazard ratio for MACEs was 1.291 (95% confidence interval: 1.091–1.527, p = 0.003) per standardized deviation in the log-transformed Lp(a) level after adjustment for traditional cardiovascular risk factors. Therefore, Lp(a) was an independent predictor of MACEs in Chinese patients with stable CAD who received OMT.

Baseline levels of serum high sensitivity C reactive protein and lipids in predicting the residual risk of cardiovascular events in Chinese population with stable coronary artery disease: a prospective cohort study

“…As described in previous study [ 17 ], patients were diagnosed with stable CAD if they presented with one of the following clinical phenotypes as a result of significant coronary artery atherosclerotic stenosis: 1) stable angina: chest pain precipitated by physical activity that remits with rest; 2) ischemic cardiomyopathy: cardiomyopathy caused by the atherosclerotic narrowing of coronary arteries; 3) latent coronary artery disease: disease characterized by myocardial ischemia and coronary stenosis that are identifiable by medical tests but not with apparent clinical symptoms [ 18 , 19 ]. Contrarily, acute coronary syndrome (including unstable angina and myocardial infarction), vasospastic angina, and microvascular angina were not considered into the scope of stable CAD.…”

“…As described in our previous study [ 17 ], blood samples were drawn by venipuncture after at least 10 h of overnight fasting. The blood specimens were processed and assessed at the central laboratory in each hospital.…”

“…The traditional risk factors for CAD were defined as described in our previous studies [ 17 , 21 ]. Hypertension was defined as blood pressure ≥ 140/90 mmHg in more than two measurements and/or the requirement of treatment with anti-hypertension drugs.…”

A Rare Case of Saudi Girl with Recurrent Strokes and Abnormal Multiple Thrombophilia

“…Studies have shown that in homozygous Plasminogen Activator Inhibitor-1 4G/5G Polymorphism; levels of Lipoprotein (a) are increased. Levels greater than 30 mg/dl are associated with atherosclerosis risk as well as ischemic strokes [23].…”

The association of serum total bile acid with non-alcoholic fatty liver disease in Chinese adults: a cross sectional study

“…Specific blood chemistries included fasting serum BAs, glucose and lipids, as well as liver and renal function tests. As previously described [22,23], blood samples were drawn by venipuncture after overnight fasting. The blood specimens were processed and measured at the central laboratory in The Second Xiangya hospital, which is standardized and certified.…”