Elevated Preoperative Carcinoembryonic Antigen and Vascular Endothelial Growth Factor Predict Shorter Survival in Patients with Sigmoid Colon Carcinoma

Chen, Tiejun; Yu, Liping; Li, Bin; Zhang, Fujuan; Wang, Yue; Wang, Xi; Liu, Sha; Yang, Chuankai; Qi, Hui; Yu, Man; Meng, Shuying; Chen, Tao

doi:10.7754/clin.lab.2016.160720

Cited by 5 publications

(4 citation statements)

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“…Although serum microRNA has been used to evaluate early COAD, its diagnostic advantages are not very competitive compared with other non-invasive tests [ 8 ]. Colonoscopy is the gold standard for the diagnosis of COAD, but it has not been widely used due to its high cost and invasiveness [ 9 , 10 ]. Serum carcinoembryonic antigen (CEA) is an important tumor marker for COAD diagnosis and postoperative monitoring, but in some clinical trials, the positive rate of serum CEA in patients is less than 50% [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation and verification of the clinical significance and perspective of natural killer group 2 member D ligands in colon adenocarcinoma

Ruan

Wang

Zhu

et al. 2021

Aging

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Section: Introductionmentioning

confidence: 99%

Investigation and verification of the clinical significance and perspective of natural killer group 2 member D ligands in colon adenocarcinoma

Ruan

Wang

Zhu

et al. 2021

Aging

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“…Common biomarkers of CRC, such as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) of TMs, have the merits of simplicity, availability, and robustness. They are generated and released during tumorigenesis, and can potentially reflect tumor changes at cellular levels (7,8). However, TMs are mostly tumorrelated, and host-related factors as markers are less reported.…”

Section: Introductionmentioning

confidence: 99%

Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer

et al. 2022

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ObjectiveWe investigated the clinical significance of preoperative pan-immune-inflammation value (PIV) in patients with colorectal cancer (CRC).MethodsIn this retrospective study, 366 cases who underwent surgery for CRC were enrolled. Their clinical data were collected. PIV was calculated with the formula PIV = [neutrophil count (109/L)× platelet count (109/L) × monocyte count (109/L) /lymphocyte count (109/L). Patients were divided into high PIV (> median PIV) and low PIV (< median PIV) groups. The relationship between PIV and clinicopathological features of CRC was investigated. Receiver operating characteristic (ROC) curve was plotted to indicate the value of immune-inflammatory biomarkers (IIBs) in predicting the TNM stage of CRC, and the area under the curve (AUC) was calculated to evaluate the actual clinical value of IIBs. AUC > 0.5 and closer to 1 indicated the better predictive efficacy. The influencing factors of PIV in CRC were analyzed.ResultsWe found that PIV was positively correlated with tumor size (r = 0.300, p < 0.05), carcinoembryonic antigen (CEA) (r = 0.214, p < 0.05) and carbohydrate antigen 125 (CA-125) (r = 0.249, p < 0.05), but negatively correlated with albumin (Alb) (r = −0.242, p < 0.05). PIV was significantly different in patients with different tumor locations (left or right), surgical methods (laparotomy versus laparoscopic surgery) (p < 0.05), and patients with different pathological T stages, N-stage and TNM stages (p < 0.05). ROC curve analysis of IIBs showed the AUC of PIV was greater than other markers when combined with CEA or carbohydrate antigen 19–9 (CA19–9). Multivariate regression analysis identified T stage, CEA, Alb, and tumor size as the independent influential factors of PIV in CRC.ConclusionPIV is associated with the tumor stage in patients with CRC, which may be useful in preoperative assessment of CRC.

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“…Serum tumor markers are produced and released during tumorigenesis and the levels of serum tumor markers may be indicative of tumor growth (Jo et al, 2013). Many valuable studies had suggested that preoperative serum carcinoembryonic antigen (CEA) levels could be used as independent risk factors to estimate the prognosis of CRC patients (Chen et al, 2017;Kozman et al, 2018;Peng et al, 2015). However, the high rate of serum CEA in CRC patients was less than 50% in some clinical trials (Huang et al, 2017(Huang et al, , 2018Shinkins et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients

Kuang

Gong

Xie

et al. 2020

PeerJ

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Background and Purpose There had been no recognized serum tumor marker to predict the prognosis of colorectal cancer (CRC) patients with normal preoperative serum carcinoembryonic antigen (CEA) levels. The purpose of this study was to determine whether preoperative serum carbohydrate antigen 724 (CA724) was of predictive function for the prognosis of CRC patients with normal CEA levels. Methods The medical records of 295 CRC patients with normal CEA levels who underwent surgery at the Department of Colorectal Anal Surgery of the First Affiliated Hospital of Guangxi Medical University (Guangxi, China) between September 2012 and September 2014 were retrospectively reviewed. The Chi-square test was used to test the correlation between preoperative serum CA724 levels and clinical features. Kaplan–Meier curves were conducted to calculate the overall survival (OS) rate and disease-free survival (DFS) of patients. Cox regression analysis was applied to conduct univariate and multivariate analysis of the following four preoperative serum tumor makers namely CA724, carbohydrate antigen 199 (CA199), carcinoembryonic antigen 125 (CA125), carcinoembryonic antigen 242 (CA242) and clinical features. Nomograms for prognostic parameter of OS and DFS were developed using R v3.2.5. Results In the Chi-square test, only pathological node stage (pN stage) (X2 = 14.514, P = 0.001) and differentiation (X2 = 10.712, P = 0.001) were associated with serum CA724 levels. In the Kaplan–Meier analysis, the results revealed that the OS and DFS in patients with high CA724 was poorer than those with normal. In the multivariate Cox regression analysis of OS and DFS, only pT stage, pN stage, metastasis and serum CA724 were independent prognostic risk factors for CRC patients with normal CEA levels. Conclusion Preoperative serum CA724 might serve as a potential prognostic factor for CRC patients with normal serum CEA levels.

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Elevated Preoperative Carcinoembryonic Antigen and Vascular Endothelial Growth Factor Predict Shorter Survival in Patients with Sigmoid Colon Carcinoma

Abstract: Elevated preoperative serum CEA and tumor VEGF were predictors of poor prognosis for patients with SCC.

Cited by 5 publications

References 0 publications

Investigation and verification of the clinical significance and perspective of natural killer group 2 member D ligands in colon adenocarcinoma

Investigation and verification of the clinical significance and perspective of natural killer group 2 member D ligands in colon adenocarcinoma

Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer

The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients

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