Elevated Preoperative Serum CA125 Predicts Larger Tumor Diameter in Patients with Hepatocellular Carcinoma and Low AFP Levels

Zhou, Sanshun; Wang, Zusen; Li, Manjiang; Wu, Liqun

doi:10.1155/2019/6959637

Cited by 11 publications

(15 citation statements)

References 28 publications

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“…MUC16, which encodes a protein also known as ovarian carcinoma antigen CA125, has been recognized as a crucial factor in hepatocarcinogenesis [22] and its usefulness as a diagnostic and prognostic marker has been demonstrated [23]. The present results demonstrated that the presence of MMs in MUC16 was associated with viral hepatitis, higher tumor markers and vascular invasion.…”

Section: Discussionsupporting

confidence: 53%

Overview and Clinical Significance of Multiple Mutations in Individual Genes in Hepatocellular Carcinoma

Imamura

Okamura

Ohshima

et al. 2021

Preprint

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BackgroundMultiple mutations (MMs) within individual oncogenes have been newly characterized as a mechanism for promotion of carcinogenesis. We investigated the spectra of the MMs and the clinical significance in hepatocellular carcinoma (HCC). MethodsWhole-exome sequencing and gene expression profiling were performed in 223 surgically resected HCCs. ResultsMMs within individual genes was identified in 178 samples (79.8%, MMs tumors). All the remaining samples carried single mutation (20.2%, SM tumors). Mutations identified as MMs show different mutational patterns with higher functional impact compared with mutations identified as SM. Recurrence-free survival was significantly worse in the group with MMs tumors than the group with SM tumors (P = 0.012). MMs tumor was identified as an independent predictor for worse prognosis (hazard ratio, 1.72; 95%, P = 0.045). MMs were observed particularly in MUC16 (15% of samples with at least one mutation in the gene) and CTNNB1 (14%). Although there was no significant difference in MUC16 mRNA expression between MUC16 wild-type and MUC16 SM tumors, the expression in MUC16 MMs tumors was significantly enhanced compared with MUC16 SM tumors (P < 0.001). MMs in MUC16 were associated with viral hepatitis, higher tumor markers and vascular invasion. Recurrence-free survival was significantly worse in the MUC16 MMs group than the MUC16 SM group (P = 0.022); no significant difference was observed between the MUC16 SM group and MUC16 wild-type group (P = 0.324).ConclusionsMMs are relatively common driver events that selectively occur in specific oncogenes and function in tumor-promoting activity.

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Section: Discussionsupporting

confidence: 53%

Overview and Clinical Significance of Multiple Mutations in Individual Genes in Hepatocellular Carcinoma

Imamura

Okamura

Ohshima

et al. 2021

Preprint

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“…Lopez et al (19) demonstrated that the CA125 cutoff values for patients with HCC were 55 U/ml in women and 12 U/ml in men. To date, the major focus of studies on CA125 levels and HCC was on the diagnosis, and only a limited number of studies have focused on the prognosis of HCC (13,15,24). In addition, the association between CA125 and prognosis in patients with HBV-related HCC has not been widely reported.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated that CA125 provides a reference value for the prognostic evaluation of patients with various types of tumor, such as pancreatic, epithelial ovarian and lung cancer (21)(22)(23). Zhou et al (24) have reported that high preoperative serum CA125 levels predict a large tumor diameter and poor prognosis following liver resection in patients with HCC with AFP levels ≤200 ng/ml. To date, the association between CA125 levels and prognosis of patients with HBV-related HCC has not been reported in detail; although certain retrospective reports have identified an association between them (13,24), further studies are needed to confirm this.…”

Section: Introductionmentioning

confidence: 99%

“…Zhou et al (24) have reported that high preoperative serum CA125 levels predict a large tumor diameter and poor prognosis following liver resection in patients with HCC with AFP levels ≤200 ng/ml. To date, the association between CA125 levels and prognosis of patients with HBV-related HCC has not been reported in detail; although certain retrospective reports have identified an association between them (13,24), further studies are needed to confirm this. Based on the worldwide predominance of HBV-related HCC, it is essential to investigate the association between CA125 and prognosis in HBV-related HCC.…”

Section: Introductionmentioning

confidence: 99%

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Predictive effects of preoperative serum CA125 and AFP levels on post‑hepatectomy survival in patients with hepatitis B‑related hepatocellular carcinoma

Qin

Gao

et al. 2021

Oncol Lett

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The association between the serum levels of cancer antigen 125 (CA125; also termed MUC16) and the prognosis of patients with hepatocellular carcinoma (HCC) has not been widely reported to date. The aim of the present study was to determine the association between preoperative serum CA125 levels and prognosis of patients with hepatitis B virus (HBV)-related HCC after hepatectomy. The study included 306 patients with HBV-related HCC who underwent liver resection and were classified into four subgroups based on their baseline CA125 and α-fetoprotein (AFP) levels. The perioperative clinical data were compared and analyzed. Kaplan-Meier and Cox regression analyses were performed to determine the associations between patient clinicopathological characteristics and survival. The results revealed that the median follow-up time was 35 months. Patients with low preoperative serum CA125 levels presented with improved 3-year disease-free survival (DFS) (79.3 vs. 75.7%; P=0.278) and overall survival (OS) (84.4 vs. 77.1%; P=0.001) rates compared with those among patients with high preoperative serum CA125 levels. High preoperative serum CA125 levels were a risk factor associated with short DFS and OS rates in all patients. In patients with baseline AFP levels >100 ng/ml, low preoperative serum CA125 levels were significantly associated with prolonged DFS and OS rates (log-rank test P=0.002 and P=0.005, respectively). In patients with AFP levels ≤100 ng/ml, no significant differences were observed in DFS or OS rates between the high and low preoperative serum CA125 groups. Patients with high preoperative serum CA125 and AFP levels exhibited the worst prognosis (low DFS and OS rates). In conclusion, high baseline CA125 levels may be associated with a poor prognosis in patients with HBV-related HCC.

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“…AFP is one of the most widely used serological biomarkers for HCC diagnosis, with a sensitivity of 60% at a cutoff value of 20 ng/mL [ 22 ]. However, statistics show that only one-third of early-stage HCC patients can be identified using AFP detection, because the patients with significantly elevated AFP levels account for only 60%–80% of all cancer cases, and high AFP levels can also be found in non-HCC conditions [ 23 ]. PIVKA-II is a newly applied biomarker and has improved the diagnosis of HCC, with relatively high sensitivity and specificity [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Value Evaluation of microRNA-324-3p and Other Available Biomarkers in Patients With HBV Infection–Related Hepatocellular Carcinoma

Zhao

Yang

2021

Open Forum Infectious Diseases

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Background Patients with hepatitis B virus (HBV) infection are at high risk of hepatocellular carcinoma (HCC). This study aimed to evaluate the expression of microRNA-324-3p (miR-324-3p) in HBV-related HCC, and explore the clinical significance of serum miR-324-3p and other available biomarkers in the diagnosis and prognosis of HBV-related HCC. Methods Expression of miR-324-3p in HBV-infection-related cells and patients was estimated using quantitative real-time PCR. The receiver operating characteristic (ROC) curves were constructed to evaluate the diagnostic performance of serum miR-324-3p, AFP and PIVKA-II in the differentiation of HBV-related HCC from healthy controls and chronic hepatitis B (CHB). The relationship between serum miR-324-3p and patients’ clinical features was assessed using Chi-square test, and the value of miR-324-3p to predict overall survival prognosis was evaluated using Kaplan-Meier methods and Cox regression assay in patients with HBV-related HCC. Results HBV-related HCC cells had significantly increased miR-324-3p compared with normal and HBV-unrelated HCC cells, and serum miR-324-3p in HCC patients with HBV infection was also higher than that in healthy controls and CHB. Serum miR-324-3p had relatively high diagnostic accuracy for the screening of HCC case with HBV infection, and the combination of miR-324-3p, AFP and PIVKA-II showed the improved diagnostic performance. Additionally, high serum miR-324-2p in HBV-related HCC patients was associated with cirrhosis, tumor size, clinical stage and poor overall survival prognosis. Conclusion Serum increased miR-324-3p may be involved in the progression of HBV-related hepatitis to HCC, and may serve as a candidate biomarker for the diagnosis and prognosis of HBV-related HCC.

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Elevated Preoperative Serum CA125 Predicts Larger Tumor Diameter in Patients with Hepatocellular Carcinoma and Low AFP Levels

Cited by 11 publications

References 28 publications

Overview and Clinical Significance of Multiple Mutations in Individual Genes in Hepatocellular Carcinoma

Overview and Clinical Significance of Multiple Mutations in Individual Genes in Hepatocellular Carcinoma

Predictive effects of preoperative serum CA125 and AFP levels on post‑hepatectomy survival in patients with hepatitis B‑related hepatocellular carcinoma

Clinical Value Evaluation of microRNA-324-3p and Other Available Biomarkers in Patients With HBV Infection–Related Hepatocellular Carcinoma

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