Predictive effects of preoperative serum CA125 and AFP levels on post‑hepatectomy survival in patients with hepatitis B‑related hepatocellular carcinoma

Abstract

The association between the serum levels of cancer antigen 125 (CA125; also termed MUC16) and the prognosis of patients with hepatocellular carcinoma (HCC) has not been widely reported to date. The aim of the present study was to determine the association between preoperative serum CA125 levels and prognosis of patients with hepatitis B virus (HBV)-related HCC after hepatectomy. The study included 306 patients with HBV-related HCC who underwent liver resection and were classified into four subgroups based on their baseline CA125 and α-fetoprotein (AFP) levels. The perioperative clinical data were compared and analyzed. Kaplan-Meier and Cox regression analyses were performed to determine the associations between patient clinicopathological characteristics and survival. The results revealed that the median follow-up time was 35 months. Patients with low preoperative serum CA125 levels presented with improved 3-year disease-free survival (DFS) (79.3 vs. 75.7%; P=0.278) and overall survival (OS) (84.4 vs. 77.1%; P=0.001) rates compared with those among patients with high preoperative serum CA125 levels. High preoperative serum CA125 levels were a risk factor associated with short DFS and OS rates in all patients. In patients with baseline AFP levels >100 ng/ml, low preoperative serum CA125 levels were significantly associated with prolonged DFS and OS rates (log-rank test P=0.002 and P=0.005, respectively). In patients with AFP levels ≤100 ng/ml, no significant differences were observed in DFS or OS rates between the high and low preoperative serum CA125 groups. Patients with high preoperative serum CA125 and AFP levels exhibited the worst prognosis (low DFS and OS rates). In conclusion, high baseline CA125 levels may be associated with a poor prognosis in patients with HBV-related HCC.

The Coefficient of Variation of Red Blood Cell Distribution Width Combined with Cancer Antigen 125 Predicts Postoperative Overall Survival in Endometrial Cancer

“… 19 Consistent with previous studies, our results suggest that CA125 is an adverse prognostic factor for EC. However, the specificity of CA125 as a tumor marker of EC is not high because the serum CA125 level will increase to varying degrees when non-EC patients suffer from endometriosis, 6 hepatitis 7 and tuberculosis, 20 when pregnant, or when in the inflammatory response period. Therefore, in the present study, we combined RDW-CV with CA125 for prognosis analysis, and the results showed that compared with CA125 or RDW-CV alone, RDW-CV+CA125 had a better prognostic value.…”

“…At present, cancer antigen 125 (CA125), is associated with the prognosis of EC. 5 However, when patients with non-EC suffer from endometriosis, 6 hepatitis, 7 or when the body is in the inflammatory response period, the level of serum CA125 will also increase to varying degrees. Therefore, the specificity of CA125 as a tumor marker for EC is not high, and it is not recommended to use CA125 alone as a prognostic indicator of EC.…”

Table_1.xls

“…Besides, there was a higher mutation rate occurred in MUC16 gene in the IRGPI highrisk group than IRGPI low-risk group (18 vs. 11%). It has been reported that high baseline MUC16 level is associated with poor prognosis in patients with HBV-related HCC (Qin et al, 2021). The two exemplar genes indicated that IRGPI high-risk patients bearing high TP53 and MUC16 mutations often have worse outcomes than IRGPI low-risk patients bearing low TP53 and MUC16 mutations, which is in agreement with the results of survival analysis.…”

Systemic Immune-Inflammatory Index as a Predictor of Lymph Node Metastasis in Endometrial Cancer

“… 10 Many studies have shown that CA125 can predict LNM in EC. 11 However, the level of serum CA125 can increase to varying degrees, such as in endometriosis 12 and hepatitis, 13 which indicates that the specificity of CA125 as a tumor marker for EC is not high. Therefore, it is of great significance to actively seek scientific and effective LNM prediction methods for the formulation of treatment plans for patients with EC.…”