Elevated Pretreatment Fibrinogen-to-Lymphocyte Percentage Ratio Predict Tumor Staging and Poor Survival in Non-Small Cell Lung Cancer Patients with Chemotherapy or Surgery Combined with Chemotherapy

Liu, Meifang; Yang, Jie; Wan, Lei; Zhao, Rui

doi:10.2147/cmar.s308659

Cited by 7 publications

(10 citation statements)

References 38 publications

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“…showed worse OS and DFS in patients with esophageal squamous cell carcinoma after radical esophagectomy with elevated preoperative FLR. Similarly, poorer OS was observed in non-small cell lung cancer patients with high FLR in a study of Liu et al [18]. The negative prognostic value of FLR was even shown in patients with gastric cancer.…”

Section: Discussionmentioning

confidence: 68%

“…Based on three prior studies, showing the prognostic significance of FLR in esophageal [16], gastric [17], and non-small lung cancer [18], we wanted to examine the role of FLR in ACC.…”

Section: Discussionmentioning

confidence: 99%

“…Based on these findings, it can be hypothesized that a ratio between serum fibrinogen and lymphocyte count could predict worse survival outcome in tumor patients. Indeed, the novel prognosticator fibrinogen-to-lymphocyte ratio (FLR) was recently proposed, and studies in esophageal cancer, gastric cancer, and non-small lung cancer attested the FLR's prognostic value [16][17][18]. In particular, higher FLR values were associated with worse outcome.…”

Section: Introductionmentioning

confidence: 99%

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The Potential Prognostic Value of a Novel Hematologic Marker Fibrinogen-to-Lymphocyte Ratio in Head and Neck Adenoid-Cystic Carcinoma

Brkic

Stoiber

Friedl

et al. 2021

JPM

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Many patients with adenoid-cystic carcinoma (ACC) experience an indolent course of disease over many years but face late recurrence, and long-term survivors are rare. Due to its infrequent occurrence, it is hard to predict outcome in these patients. The fibrinogen-to-lymphocyte ratio (FLR) was recently proposed as an outcome prognosticator in different cancer entities. We aimed to investigate its prognostic relevance in patients with head and neck ACC. This retrospective analysis was performed including all patients treated for ACC between 1998 and 2020. The FLR ratio was calculated based on pretreatment values (0–7 days). The study cohort was dichotomized based on optimized threshold value and compared for differences in outcome (overall survival (OS) and disease-free survival (DFS)). In the cohort of 39 included patients, the OS was significantly longer in the low (n = 28) compared to the high pretreatment FLR group (n = 11) (median OS 150.5 months, 95% confidence intervals (CI) 85.3–215.7 months vs. 29.4 months, 95% CI not reached; p = 0.0093). Similarly, the DFS was significantly longer in the low FLR group (median DFS 74.5 months, 95% CI 30.6–118.4 months vs. 11.0 months, 95% CI 5.1–16.9 months; p = 0.019). The FLR is an easily obtainable and simple marker and may be a valuable outcome prognosticator in patients with ACC. Further studies are needed for validation of our results.

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Section: Discussionmentioning

confidence: 68%

“…Based on three prior studies, showing the prognostic significance of FLR in esophageal [16], gastric [17], and non-small lung cancer [18], we wanted to examine the role of FLR in ACC.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Potential Prognostic Value of a Novel Hematologic Marker Fibrinogen-to-Lymphocyte Ratio in Head and Neck Adenoid-Cystic Carcinoma

Brkic

Stoiber

Friedl

et al. 2021

JPM

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“…However, it is notable that reports regarding the role of LFR in cancer are still scarce, with only a few relevant studies but only with some relevant studies. For example, Liu et al included 375 stages 1–4 non-small cell lung cancer patients and explored the prognostic role of the FIB-to-lymphocyte percentage ratio (FLpR), and the results indicated that patients with a high FLpR would have an increased risk of death [ 46 ]. In addition, Huang et al indicated that a high FIB to LC ratio (FLR) correlated with peritoneal dissemination in gastric cancer [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Preoperative low absolute lymphocyte count to fibrinogen ratio correlated with poor survival in nonmetastatic colorectal cancer

Huang

Liu

et al. 2022

World J Surg Onc

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Background Preoperative absolute lymphocyte count (LC) and fibrinogen (FIB) are useful prognostic indicators in colorectal cancer (CRC). However, the prognostic value of the LC to FIB ratio (LFR) has never been addressed. Methods A total of 189 nonmetastatic CRC patients after resection were enrolled retrospectively. The significance of the LFR in predicting disease-free survival (DFS) and overall survival (OS) was estimated by receiver operating characteristic curve analysis, and the prognostic efficacy was compared with individual LC and FIB. Patients were assigned to LFR low or high subgroups. Differences in clinicopathological features among these subgroups were calculated, and the survival differences of these subgroups were determined by the Kaplan-Meier analysis. A Cox proportional hazards model was applied to test the risk factors for survival. Results Taking 0.54 as the optimal cutoff point, the LFR had sensitivities of 79.70% and 86.40% and specificities of 52.30% and 51.00% in predicting the DFS and OS, respectively. A total of 109/189 (57.67%) patients were assigned to the LFR low group, and these patients were more likely to be characterized by criteria such as T3 + T4 (P < 0.01), stage 3 (P < 0.01), tumor deposits (P = 0.01), high CEA (P < 0.01), or CA19-9 levels (P = 0.04). And they also displayed worse DFS (log rank = 18.57, P < 0.01) and OS (log rank = 20.40, P < 0.01) than the high LFR group. Finally, the LFR was independently associated with inferior DFS (HR = 0.32, 95% CI: 0.16–0.61, P < 0.01) and OS (HR = 0.23, 95% CI: 0.09–0.55, P < 0.01). Conclusions The LFR is a useful prognostic indicator in nonmetastatic CRC, and patients with a relatively low LFR had poor survival.

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“…Lymphocytes are important antineoplastic factors, which play a significant role in cancer-specific immune response ( 14 ). Recently, a novel prognosticator fibrinogen-to-lymphocyte ratio (FLR) has been proposed, which has been proved to evaluate the prognosis in gastric cancer ( 15 ), esophageal cancer ( 16 ), non-small cell lung cancer ( 17 ) and head and neck adenoid-cystic carcinoma ( 18 ). However, there is no study on the predictive performance of NLR and FLR in CRA recurrence.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram based on neutrophil-to-lymphocyte ratio and fibrinogen-to-lymphocyte ratio for predicting recurrence of colorectal adenoma

He¹,

Du²,

Wang³

et al. 2022

J Gastrointest Oncol

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Background: There are many risk factors for the recurrence of colorectal adenoma (CRA). The purpose of this study was to explore the predictive performance of fibrinogen-to-lymphocyte ratio (FLR) and neutrophil-to-lymphocyte ratio (NLR) on the recurrence of CRA and to construct a predictive model. Methods: This study analyzed the clinicopathological features of 421 CRA patients who underwent colonoscopy and adenectomy, and evaluated the recurrence of polyps under colonoscopy. Among them, 301 were training cohort and 120 were validation cohort. Multivariate logistic regression was used to identify independent risk factors associated with CRA recurrence. Established a nomogram model to predict the risk of recurrence in CRA patients using independent risk factors. The receiver operating characteristic (ROC) curves were used to verify the nomogram model discrimination. Calibration curves were used to verify the model calibration degree. The decision curve analysis (DCA) curves were used to verify the clinical efficacy of the nomogram model.Results: Totally, six independent predictors, including smoking, diabetes, adenoma number, adenoma size, NLR, and FLR, were enrolled in the nomogram. In the training cohort and validation cohort, the area under the curve (AUC) of the nomogram for predicting the risk of CRA recurrence was 0.846 and 0.841, respectively. The calibration curves displayed a good agreement. DCA curves showed that this model had a high net clinical benefit.Conclusions: Smoking, diabetes, adenoma number, adenoma size, NLR, and FLR were influencing factors for CRA recurrence.

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Elevated Pretreatment Fibrinogen-to-Lymphocyte Percentage Ratio Predict Tumor Staging and Poor Survival in Non-Small Cell Lung Cancer Patients with Chemotherapy or Surgery Combined with Chemotherapy

Cited by 7 publications

References 38 publications

The Potential Prognostic Value of a Novel Hematologic Marker Fibrinogen-to-Lymphocyte Ratio in Head and Neck Adenoid-Cystic Carcinoma

The Potential Prognostic Value of a Novel Hematologic Marker Fibrinogen-to-Lymphocyte Ratio in Head and Neck Adenoid-Cystic Carcinoma

Preoperative low absolute lymphocyte count to fibrinogen ratio correlated with poor survival in nonmetastatic colorectal cancer

Development and validation of a nomogram based on neutrophil-to-lymphocyte ratio and fibrinogen-to-lymphocyte ratio for predicting recurrence of colorectal adenoma

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