Elevated serum CA125 and CA19-9 due to the spontaneous rupture of ovarian endometrioma

Kurata, Hiroyuki; Sasaki, Masaru; Kase, Hiroaki; Yamamoto, Yasuaki; Aoki, Yoichi; Tanaka, Kenichi

doi:10.1016/s0301-2115(02)00139-2

Cited by 41 publications

(40 citation statements)

References 6 publications

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“…The mechanism related to the elevation of serum CA125 and CA19‐9 concentrations is not clearly identified. Kurata et al 14 . suggested that the diffusion of cystic fluid after rupture of an endometrioma over the peritoneal surface and into the circulation probably was a contributing factor to the rapid increase in serum CA125 and CA19‐9 concentrations, but not to its persistent elevation 14 .…”

Section: Discussionmentioning

confidence: 99%

Massive peritoneal fluid and markedly elevated serum CA125 and CA19‐9 levels associated with an ovarian endometrioma

Park

Kim

2009

J of Obstet and Gynaecol

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Endometriosis associated with ascites is an uncommon condition, but nevertheless important because it mimics the presentation of ovarian malignancy. We present the case of a 34-year-old woman who was admitted with the acute onset of abdominal pain and distension. A pelvic sonogram showed a large amount of peritoneal fluid with echogenic material and a 10-cm complex cystic structure, which appeared to be an enlarged left ovary. The concentrations of CA125 and CA19-9 were 548.1 and 7604 IU/mL, respectively. On the second day of admission, an exploratory laparoscopy was performed, which revealed a ruptured left ovarian cyst consistent with an endometrioma. A laparoscopic left adnexectomy was therefore performed. The histological examination of the specimen confirmed the diagnosis of an endometrioma. After a 12-month follow-up period, the patient showed no recurrence of the endometrioma or peritoneal fluid accumulation. In most instances, the presence of massive ascites is associated with malignancies, tuberculosis, or a perforated viscus. The information provided in the present report is important to both gynecologists and oncologists because it shows that an ovarian cyst with ascites and highly elevated CA125 and CA19-9 levels might be benign.

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Section: Discussionmentioning

confidence: 99%

Massive peritoneal fluid and markedly elevated serum CA125 and CA19‐9 levels associated with an ovarian endometrioma

Park

Kim

2009

J of Obstet and Gynaecol

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“…According to the authors, the thick wall of the endometriotic cyst prevents the large CA125 glycoprotein molecules from reaching the peripheral circulation [8]. Kurata et al reported the highest CA125 serum level of 9,537 IU/mL in a ruptured endometrioma, which was confirmed by histological analysis as well [9]. In that case, the serum CA19-9 level was 15,653 IU/mL and CA125 and CA19-9 levels in the peritoneal fluid were 160,000 and 208,192 IU/mL, respectively.…”

Section: Discussionmentioning

confidence: 99%

Relation of high CA125 and CA19-9 levels with recent rupture of endometrioma

et al. 2011

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Most of endometriomas with CA125 level over 1,000 IU/mL have related with rupture. This is important in differential diagnosis from malign ovarian disease. However, the mechanism of elevation of CA125 in patients with endometrioma is not clear. We reviewed elevation of CA125 level over 1,000 IU/mL in endometriomas and attempted to explore possible mechanisms of this elevation together with presentation of our current case. A review of the literature suggests that extremely elevated CA125 level combined with high CA19-9 level may indicate a recent rupture of endometrioma.

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“…[19][20][21][22] In en domet ri o sis, se rum le vel of CA 125 and CA 19-9 is ex pec ted to be no mo re than 100 IU/ml and 1000 IU/ml, res pec ti vely. Ho we ver, very high se rum levels of CA 125 and CA 19-9 (CA 125: 9537 IU/ml, CA 19-9: 15.653 IU/ml) was re cor ded in a pa ti ent with rup tu red ova ri an en do met ri o ma.…”

Section: Medical Pathologymentioning

confidence: 99%

“…Ho we ver, very high se rum levels of CA 125 and CA 19-9 (CA 125: 9537 IU/ml, CA 19-9: 15.653 IU/ml) was re cor ded in a pa ti ent with rup tu red ova ri an en do met ri o ma. 20 The mec ha nisms that may ele va te se rum le vels of CA 125 and CA 19-9 in en do met ri o sis are not yet cle arly unders to od; ho we ver, the dif fu si on of cyst flu id through the pe ri to neal sur fa ce in to the cir cu la ti on is con si de red in so me ca ses. 20 We be li e ve that UOM was de ve lo ped du e to the me tap la si a of ova ri an en do met ri o ma in our pati ent.…”

Section: Medical Pathologymentioning

confidence: 99%

“…20 The mec ha nisms that may ele va te se rum le vels of CA 125 and CA 19-9 in en do met ri o sis are not yet cle arly unders to od; ho we ver, the dif fu si on of cyst flu id through the pe ri to neal sur fa ce in to the cir cu la ti on is con si de red in so me ca ses. 20 We be li e ve that UOM was de ve lo ped du e to the me tap la si a of ova ri an en do met ri o ma in our pati ent. First, no uro ge ni tal ab nor ma lities were found on ra di o lo gic eva lu a ti ons.…”

Section: Medical Pathologymentioning

confidence: 99%

See 1 more Smart Citation

Uterus-Like Ovarian Mass with Elevated Serum Levels of CA 19-9 and CA 125: A Case Report and Review of the Literature

Kelten¹,

Yalçin²,

Çoban³

et al. 2010

Turkiye Klinikleri J Med Sci

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Elevated serum CA125 and CA19-9 due to the spontaneous rupture of ovarian endometrioma

Cited by 41 publications

References 6 publications

Massive peritoneal fluid and markedly elevated serum CA125 and CA19‐9 levels associated with an ovarian endometrioma

Massive peritoneal fluid and markedly elevated serum CA125 and CA19‐9 levels associated with an ovarian endometrioma

Relation of high CA125 and CA19-9 levels with recent rupture of endometrioma

Uterus-Like Ovarian Mass with Elevated Serum Levels of CA 19-9 and CA 125: A Case Report and Review of the Literature

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