Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients

Fujita, Ayano; Ihira, Masaru; Suzuki, Ryota; Enomoto, Yoshihiko; Sugiyama, Haruko; Sugata, Ken; Suga, S.; Asano, Yoshizo; Yagasaki, Hiroshi; Kojima, Seiji; Matsumoto, Kimikazu; Kato, Koji; Yoshikawa, Tetsushi

doi:10.1016/j.jinf.2008.06.014

Cited by 38 publications

(28 citation statements)

References 46 publications

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“…Additional experiments will be needed to understand whether proinflammatory cytokines such as TNF-␣ and IL-6, whose levels are significantly elevated in active SLE patients, 19 might play an important role in viral reactivation of HHV-6, as demonstrated in patients with drug-induced hypersensitivity syndrome 20 and in hematopoietic stem cell transplantation recipients. 21 …”

Section: Discussionmentioning

confidence: 99%

Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases

Broccolo¹,

Drago²,

Paolino³

et al. 2009

Journal of Clinical Virology

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Section: Discussionmentioning

confidence: 99%

Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases

Broccolo¹,

Drago²,

Paolino³

et al. 2009

Journal of Clinical Virology

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“…It has been suggested that several cytokines might be involved in causing HHV-6 encephalitis. 4 Additionally, our recent studies suggested that several inflammatory cytokines were upregulated by HHV-6 reactivation and these may contribute to the associated clinical manifestations in transplant recipients 5,6 and patients with drug induced hypersensitivity syndrome. 7 over, in vitro studies demonstrated that HHV-6 can modulate host immunity by several mechanisms, including killing lymphocytes and controlling cytokine synthesis.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of cytokine and chemokine responses in patients with primary human herpesvirus 6 infection

Yoshikawa

Kato

Ihira

et al. 2011

Journal of Clinical Virology

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“…12 Elevated IL-6 level in the blood are considered to be associated with HHV-6 reactivation and development of HHV-6 encephalitis. 14,15 In our case, acute GVHD involving the skin and neutrophil engraftment had already appeared before development of pericarditis. Hypercytokinemia derived from acute GVHD and engraftment may affect HHV-6 reactivation.…”

Section: Figure 1 Computed Tomography Scan Taken On Day 28mentioning

confidence: 57%

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Yoshida

Nakamae²,

Okamura³

et al. 2017

Exp Clin Transplant

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A 53-year-old woman with myelodysplastic syndrome received a cord blood transplant because she had frequent episodes of febrile neutropenia. As a conditioning regimen for transplant, she received 12 Gy total body irradiation, intravenous cytosine arabinoside 3 g/m 2 every 12 hours on days -5 and -4, and cyclophosphamide 60 mg/kg/day on days -3 and -2. She received tacrolimus and short-term methotrexate treatment as prophylaxis for graftversus-host disease. Her cardiac function was normal before transplant. She developed acute heart failure with a mild pericardial effusion 11 days after transplant, but her failure improved with a diuretic, vasodilator, and inotropic agent. She complained of dyspnea, and chest auscultation revealed pericardial friction rubs on day 28. Massive pericardial effusion was detected by echocardiography and pericarditis was diagnosed. The pericardial space was drained by pericardiocentesis. The pericardial fluid was exudative, but no bacteria or fungi were cultured. On viral polymerase chain reaction examination, human herpesvirus-6 was detected at a level of 3 × 10 4 copies/mL in the pericardial effusion, but not in the peripheral blood. With conservative treatment alone, that did not include antiviral therapy, her symptoms disappeared on day 56. We conclude that human herpesvirus-6 reactivation may have been associated with her pericarditis.

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Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients

Cited by 38 publications

References 46 publications

Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases

Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases

Kinetics of cytokine and chemokine responses in patients with primary human herpesvirus 6 infection

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