Elevated serum fibrinogen/albumin ratios in patients with acute central serous chorioretinopathy

Limon, Utku; Bozkurt, Erdinç; Bulut, Sinan; Ilkay, Betül; Akçay, Sezgin

doi:10.1177/11206721221089773

Cited by 4 publications

(7 citation statements)

References 36 publications

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“…Increased plasma fibrinogen concentrations indicate that systemic inflammation was present in both groups of dogs, but to a significantly greater extent in the SARDS group. Cross talk between inflammation and coagulation is well described, 41,42 such that increased fibrinogen plasma concentrations are associated with enhanced thrombosis risk 34,43,44 . It was not possible with our study design to determine whether the inflammatory response seen in dogs with SARDS was acute or chronic.…”

Section: Discussionmentioning

confidence: 99%

“… 26 , 27 , 28 Hypercortisolism is common in people with CSCR. 29 , 30 , 31 , 32 , 33 Patients with CSCR have increased plasma fibrinogen concentration 34 and are at higher risk for thrombotic events. The proposed pathophysiology is that thrombosis limits choroidal perfusion, causing ischemic choroidal effusion and subsequent bullous retinal detachment.…”

Section: Discussionmentioning

confidence: 99%

“…The proposed pathophysiology is that thrombosis limits choroidal perfusion, causing ischemic choroidal effusion and subsequent bullous retinal detachment. 29 Patients with CSCR are also at a higher risk of thrombotic events, including retinal vein occlusion 34 and cerebrovascular accidents. 35 Consequently, we hypothesize that intravascular thrombosis contributes to impaired choroidal circulation in dogs with SARDS associated with a systemic hypercoagulable state.…”

Section: Discussionmentioning

confidence: 99%

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Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome

Lynch

Ruterbories

Robertson

et al. 2023

Veterinary Internal Medicne

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Background Sudden acquired retinal degeneration syndrome (SARDS) is a common cause of irreversible blindness in dogs. It bears clinical resemblance to hypercortisolism, which can be associated with hypercoagulability. The role of hypercoagulability in dogs with SARDS is unknown. Objective Determine hemostatic profiles in dogs with SARDS. Animals Prospective pilot study: Dogs with a history of SARDS (n = 12). Prospective case‐control study: Dogs with recent onset of SARDS (n = 7) and age‐, breed‐, and sex‐matched controls (n = 7). Methods Prospective pilot study: We performed thromboelastography (TEG). Prospective case‐control study: Dogs had CBC, serum biochemistry, urinalysis, TEG, fibrinogen concentration, antithrombin activity, D‐dimers, thrombin‐antithrombin complexes, and optical platelet aggregometry performed. Results Prospective pilot study: 9/12 dogs with a history of SARDS were hypercoagulable with increased TEG G value and 2/3 had hyperfibrinogenemia. Case‐control study: All dogs with SARDS and 5/7 controls were hypercoagulable based on TEG G value. Dogs with SARDS had significantly higher G values (median, 12.7 kdynes/s; range, 11.2‐25.4; P = .04) and plasma fibrinogen concentration (median, 463 mg/dL; range, 391‐680; P < .001) compared to controls. Conclusions and Clinical Importance Hypercoagulability was common in both dogs with SARDS and controls, but dogs with SARDS were significantly more hypercoagulable on TEG. The role of hypercoagulability in the pathogenesis of SARDS remains to be determined.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome

Lynch

Ruterbories

Robertson

et al. 2023

Veterinary Internal Medicne

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“…Their group identified a statistically significant increase in monocyte-to-high-density lipoprotein ratio in patients with acute CSCR compared to healthy controls. Limon et al [38] conducted a study evaluating serum fibrinogen/ albumin ratios in patients with acute and chronic CSCR.…”

Section: Inflammation and Central Serous Chorioretinopathymentioning

confidence: 99%

Pathomechanisms in central serous chorioretinopathy: A recent update

et al. 2023

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Background Central serous chorioretinopathy (CSCR) is a potentially blinding choroidal disease. Despite decades of research, the pathological mechanisms of CSCR are still poorly understood. In recent years, there has been a strong emphasis on choroidal dysfunction as a primary cause of CSCR. Main Body The concept of the pachychoroid disease spectrum and pachychoroid-driven processes are central to current theories regarding the pathophysiological underpinnings of CSCR. Choroidal hyperpermeability and subsequent leakage of fluid seen in CSCR may be due to several causes. Among them are venous congestion, inflammation, mineralocorticoid receptor activation, systemic factors including hemodynamic changes, obstructive sleep apnea, phosphodiesterase inhibitor use, pregnancy, and genetic predispositions. Congestion of vortex veins that drain blood from the choroid may contribute to the dilation of Haller vessels and cause fluid leakage. Vortex veins exit the eye through the sclera; thus, increased scleral thickness has been proposed to be a factor in venous congestion. Asymmetric vortex vein drainage may similarly result in congestion of the local venous system. Vortex vein anastomoses may overload the venous system and form secondary to venous congestion. Recent studies suggest inflammation and mineralocorticoid activation may factor into the development of CSCR, though more research in these areas is called for. Systemic conditions and genetics may predispose individuals to develop CSCR. Conclusions By striving to understand the molecular and physiological mechanisms of this disease, we can better diagnose and treat CSCR to improve outcomes for patients.

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“… 13 Other groups described that the serum fibrinogen/albumin ratio and interleukin (IL)-6 level were elevated in patients with CSCR. 14 , 15 …”

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confidence: 99%