Elevated serum levels of interleukin -22 and interleukin-23 in pediatric asthma

Abstract

Background: There are few studies had addressed the association between serum levels of Interleukin -22 and Interleukin-23 with severity of asthma, this study aims to evaluate whether elevated IL-22 and IL-23 serum levels is related to the severity of asthma. Methods: This study is a case-control study that included 60 asthmatic children (35 male and 25 female) as the patients group age ranged between 4 months to 14 years old, and 60 non-asthmatic (32 male and 28 female) age-matched patients group attending the outpatient clinic were recruited as control group. Serum levels of IL-22 and IL-23 was measured by sandwich ELISA using ELISA kits. Results: The results of this study have shown an elevated serum level of IL-23 in patients group compared with control group with significant (p= 0.008) and there was no significant difference between patients and control regarding IL-22 serum level (p = 0.721) in asthmatic children. Conclusion: According to the current study the serum level of IL-23 showing a significant association with the asthma severity in children.

Mechanism of Th17 and Treg in Allergic Rhinitis

“…IL-23's effect on serum IgE level is unclear due to controversial results of experiments on serum IL-23 and IgE association. According to Manti and others, a positive correlation was observed between serum levels of IL-23 and IgE, while another study suggested non-significant negative correlation and no significant association [26].…”