Elevated serum lipoprotein(a) levels in young women with endometriosis

Crook, David; Howell, Rosemary; Sidhu, Mandeep S.; Edmonds, D. Keith; Stevenson, John C.

doi:10.1016/s0026-0495(97)90115-3

Cited by 34 publications

(16 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a later study, Crook et al 30 demonstrated that compared with levels in control subjects, the serum level of Lp(a) was 5 times higher in patients with endometriosis, possibly because of an immune response inherent to this disorder. Our findings, along with those of Crooke et al, 18,30 are in agreement with the assumption that in endometriosis, where baseline Lp(a) levels are increased because of the dysregulation of Lp(a) metabolism, danazol lowers Lp(a) concentration by controlling the inflammatory response. This is not the case in HAE, where baseline Lp(a) levels are normal and danazol has no significant influence on Lp(a) levels.…”

Section: Discussionsupporting

confidence: 93%

Adverse effects of danazol prophylaxis on the lipid profiles of patients with hereditary angioedema

Széplaki

Varga

Valentin³

et al. 2005

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 93%

Adverse effects of danazol prophylaxis on the lipid profiles of patients with hereditary angioedema

Széplaki

Varga

Valentin³

et al. 2005

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

“…Some earlier studies on women with endometriosis show that serum HDL and LDL are similar to that of age- and adiposity-matched controls, but serum lipoprotein (a) and triglycerides are elevated [31]. The relationship between endometriosis and known CVD risk factors is complicated by the fact that women with endometriosis have a lower BMI compared to controls [32, 33] and levels of fibroblast growth factor-2 (FGF-2) are elevated in women with endometriosis [34], since FGF-2 is known to protect against myocardial dysfunction [35].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular risk factors among women with self-reported infertility

Mahalingaiah

Sun

Cheng

et al. 2017

Fertil Res and Pract

View full text Add to dashboard Cite

BackgroundAmongst women with certain types of ovulatory disorder infertility, the studies are conflicting whether there is an increased risk of long-term cardiovascular disease risk. This paper evaluates the associations of several CVD risk factors among Framingham women with self-reported infertility.MethodsWomen who completed the Framingham Heart Study Third Generation and Omni Cohort 2 Exam 2 (2008–2011), and reported on past history of infertility and current cardiovascular disease status were included in this cross-sectional study. Directly measured CVD risk factors were: resting blood pressure, fasting lipid levels, fasting blood glucose, waist circumference, and body mass index (BMI). Multivariable models adjusted for age, smoking, physical activity, and cohort. Generalized estimating equations adjusted for family correlations. We performed sensitivity analyses to determine whether the association between infertility and CVD risk factors is modified by menopausal status and menstrual cycle length.ResultsComparing women who self-reported infertility to those who did not, there was an average increase in BMI (β = 1.03 kg/m2, 95% CI: 0.18, 1.89), waist circumference (β = 3.08 in., 95% CI: 1.06, 5.09), triglycerides (β = 4.47 mg/dl, 95% CI:−1.54, 10.49), and a decrease in HDL cholesterol (β = −1.60 mg/dl, 95% CI: −3.76, 0.56). We estimated that infertile premenopausal women have an increased odds of obesity (BMI ≥ 30 kg/m2) (OR = 1.56, 95% CI: 1.11, 4.49) and diabetes (OR = 1.96, 95% CI: 0.86, 4.49).ConclusionsBMI and waist circumference were the most strongly correlated CVD risk factors amongst women reporting a history of infertility.

show abstract

“…Furthermore, Crook et al (31) also observed significantly higher levels of serum lipoprotein(a) in women with endometriosis. Hence, women with endometriosis on danazol treatment are at a higher risk of developing cardiovascular diseases in later stages of their life.…”

Section: Figurementioning

confidence: 92%