Elevated urine formaldehyde in elderly patients with primary open angle glaucoma

Abstract

Endogenous FA level is positively correlated with the neuronal defects of POAG.

Monitoring Neurodegeneration in Glaucoma: Therapeutic Implications

“…Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, has been reported to be significantly increased in patients with progressive normal tension glaucoma, compared to patients with non-progressive normal tension glaucoma [47]. Another study showed elevated urine formaldehyde in elderly patients with primary open angle glaucoma, compared to healthy controls [48]. However, in addition to a lack of contact with the eye, measurement of target molecules in urine can be confounded by the effects of filtration and reabsorption in the kidney.…”

Depression, Diabetes and Dementia: Formaldehyde May Be a Common Causal Agent; Could Carnosine, a Pluripotent Peptide, Be Protective?

“…Recent studies have highlighted the possible involvement of formaldehyde in a number of age-associated phenomena, dementia, depression and diabetes (type-2). Papers by Li et al [ 1 , 2 ], Cui et al [ 3 ], Tong et al [ 4 , 5 ] and Mei et al [ 6 ] have shown an association between formaldehyde and age-related dysfunction such as glaucoma, stroke, Alzheimer’s disease and memory decline. Furthermore, Tulpule and colleagues [ 7 , 8 ] have demonstrated that formaldehyde strongly stimulates glycolytic flux in astrocytes and neurones, implying its contribution to metabolic age-related dysfunction, (e.g.…”