Elevated visfatin levels in obese children are related to proinflammatory factors

Abstract

The association of circulating visfatin with anthropometric parameters, metabolic parameters, and inflammatory factors is dependent on gender, although no such correlation was observed between serum visfatin concentration and insulin resistance. Visfatin could bean important inflammatory cytokine representing a low grade inflammatory state in obesity.

Elevated 1‐hour post‐load plasma glucose identifies obese youth with abnormal glucose metabolism and an unfavourable inflammatory profile

“…Further, visfatin levels were found significantly higher in group 2 compared to group 1 ( P < 0.001). Visfatin is a recently described adipokine, shown to increase in children and adolescents with central obesity, with metabolic syndrome characteristics and with insulin resistance, possibly to an even greater degree than leptin and adiponectin . To the best of our knowledge, no study in adults or children has investigated visfatin levels in relation to 1h‐GL during OGTT.…”

“…Visfatin is a recently described adipokine, shown to increase in children and adolescents with central obesity, with metabolic syndrome characteristics and with insulin resistance, possibly to an even greater degree than leptin and adiponectin. 23,24,44 To the best of our knowledge, no study in adults or children has investigated visfatin levels in relation to 1h-GL during OGTT. Our results show that children with 1h-GL ≥8.6 mmol/L have higher levels of visfatin and thus, combined with their elevated IL-6…”

“…The first three have been implicated in the development of obesity complications through several different mechanisms, while adiponectin has been shown to play a protective role. [17][18][19][20][21][22][23][24] To the best of our knowledge, this is the first study in this age group to correlate IR status and specific adipokine levels with 1h-GL.…”

Actividad física, ejercicio y deporte en la lucha contra la obesidad infantil y juvenil

“…La visfatina es otra adipoquina de caracterización más reciente, producida preferentemente en el tejido adiposo visceral, y cuyos niveles se relacionan con el IMC y la concentración de triglicéridos en niños obesos, aunque no muestran correlación con la resistencia a la insulina (82). Se asocia a niveles elevados de factor de necrosis tumoral (TNF)-α e interleucina (IL)-6, siendo un posible marcador de la inflamación asociada a la obesidad infantil (83). La resistina es una molécula secretada en algunas especies por los adipocitos, aunque en humanos se expresa fundamentalmente en macrófagos, jugando un papel en la secreción de factores proinflamatorios.…”

Impact of probiotics during weaning on the metabolic and inflammatory profile: follow-up at school age

“…There is increasing evidence that obesity-associated chronic low-grade systemic inflammation is a negative risk factor for later health outcomes also in children (Nappo et al, 2013). Leptin (Roth & Reinehr, 2010) and visfatin (Li et al, 2013) are pro-inflammatory cytokines, acting as signal substances in obesity and inflammation. Plasminogen activator inhibitor-1 (PAI-1) is the primary physiological inhibitor of fibrinolysis and proteolysis linked to thrombosis and fibrosis, insulin resistance, and obesity (Mantovani et al, 2011;Mauras et al, 2010).…”