Elevation of arterial pressure in rats by two new vertebrate peptides FLF QPQRF-NH2 and AGE GLSSPFWSLAAPQRF-NH2 which are immunoreactive to FMRF-NH2 antiserum

Roth, Bryan L.; Disimone, Jerry; Majane, E. A.; Yang, Hongdian

doi:10.1016/0143-4179(87)90087-4

Cited by 108 publications

(42 citation statements)

References 10 publications

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“…Intravenous injection of NPFF has been shown to result in a significant increase in blood pressure (Roth et al, 1987;Allard et al, 1995). Allard et al suggested that NPFF might act through the stimulation of specific NPFF receptors located on vascular sympathetic terminals to evoke a pressor response.…”

Section: Distribution Of Npff In the Rat Forebrainmentioning

confidence: 96%

Neuropeptide FF distribution in the human and rat forebrain: A comparative immunohistochemical study

Goncharuk

Buijs

MacTavish

et al. 2006

J of Comparative Neurology

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Neuropeptide FF (NPFF) is an octapeptide implicated in a variety of physiological functions, including nociception, cardiovascular responses, and neuroendocrine regulation. The NPFF gene and its mRNA are highly conserved across species. A comparative study of NPFF distribution in the human and rat forebrain was carried out by using single NPFF and double NPFF + vasopressin (VP) immunohistochemistry. NPFF is extensively localized within neurochemical circuits of human and rat forebrain. Semiquantitative analysis revealed that the densities of NPFF cells and fibers in many forebrain nuclei in the human correlate well with those observed for the same structures in the rat. High numbers of NPFF positive neurons in the dorsomedial hypothalamic nucleus and a dense plexus of NPFF fibers surrounding the fornix within the bed nucleus of the stria terminalis were identified in the human and rat forebrain. Within the hypothalamus of both species, dense NPFF innervation was observed in the perinuclear zone of the supraoptic nucleus (SO) just dorsolateral to the VP-positive neurons. Extensive NPFF innervation of ventricular ependyma and brain microvasculature were common for both species. At the same time, obvious differences in NPFF localization between the two species were also apparent. For example, in contrast to the rat SO, no NPFF- or NPFF- + VP-immunostained cells were observed in the human SO. Knowledge of NPFF neuroanatomical localization in the human brain and the relationship of these observations to those in the rat brain may provide insight into the role of this peptide in central cardiovascular and neuroendocrine regulation.

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Section: Distribution Of Npff In the Rat Forebrainmentioning

confidence: 96%

Neuropeptide FF distribution in the human and rat forebrain: A comparative immunohistochemical study

Goncharuk

Buijs

MacTavish

et al. 2006

J of Comparative Neurology

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“…Thus, because the influence of the tetrapeptide on the cardiovascular functions in mammals [Mues et al, 1982;Wong et al, 1985;Roth et al, 1987] are well known we speculate that in the viviparous skink brain, FMRFamide-ir neurons surrounding blood vessels could be related to the regulation of the blood pressure. Furthermore, the presence of FMRFamide-ir fiber endings in the median eminence, one of the most obvious characteristics that viviparous skink shares with all tetrapods, viz., mammals [Weber et al, 1981;Chronwall et al, 1984;Triepel and Grimmelikhujizen, 1984b;Chen et al, 1989;Kivipelto et al, 1991;Kivipelto, 1991;Oelschläger et al, 1998], birds [Fujii and Kobayashi, 1992b], ruin lizard [Vallarino et al, 1994], amphibians , leads us to consider the possible involvement of FaRPs in the control of the pituitary.…”

Section: Functional Aspectsmentioning

confidence: 99%

“…The original tetrapeptide plays a variety of roles in mammals, e.g., influence on cardiovascular functions [Mues et al, 1982;Wong et al, 1985;Roth et al, 1987], modulation of opioid activity in the brain and spinal neurons [Gayton, 1982;Guzman et al, 1989;Allard et al, 1991Allard et al, , 1994Aarnisalo and Panula, 1995;Devillers et al, l995;Dupouy and Zajac, 1995;Marco et al, 1995;Gouarderes et al, 1996;Panula et al, 1996], and stimulation of grooming behavior [Gayton, 1982]. Peptides belonging to FMRFamide family are easily visualized in the nervous system by using antibodies raised against the tetrapeptide.…”

Section: Introductionmentioning

confidence: 99%

Localization of FMRFamide-Like Immunoreactivity in the Brain of the Viviparous Skink <i>(Chalcides chalcides)</i>

D’Aniello¹,

Fiorentin²,

Pinelli³

et al. 2001

Brain Behav Evol

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Neuroanatomical distribution of FMRFamide-like immunoreactivity was investigated in the brain and olfactory system of the viviparous skink, Chalcides chalcides. In the adult brain FMRFamide immunoreactive (ir) perikarya were observed in the diagonal band of Broca, medial septal nucleus, accumbens nucleus, bed nucleus of the anterior commissure, periventricular hypothalamic nucleus, lateral forebrain bundle, and lateral preoptic, subcommissural, suprachiasmatic and lateral hypothalamic areas. This pattern was seen in both male and female brains. Though all major brain areas showed FMRFamide-ir innervation, the densest ir fiber network was observed in the hypothalamus. During development, ir elements were observed for the first time in embryos at mid-pregnancy. FMRFamide perikarya were located along the ventral surface of the vomeronasal nerve, in the olfactory peduncle mediobasally, as well as in the anterior olfactory nucleus and olfactory tubercle. Furthermore, some ir neurons were observed in the rhombencephalic reticular substance; however, the ir fiber network was poorly developed. Later in development FMRFamide-ir neurons appeared also in the bed nucleus of the anterior commissure as well as the rhombencephalic nucleus of solitary tract and the dorsal motor nucleus of vagus nerve. In juveniles, the distribution profile of FMRFamide immunoreactivity was substantially similar to that of the adults, with a less widespread neuronal distribution and a more developed fiber network. Ontogenetic presence of FMRFamide immunoreactivity in the nasal area has been linked to the presence of a nervus terminalis in this reptile.

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“…In rodents, NPFF exerts a modulatory action on a variety of behavioural and physiological responses (Roth et al, 1987;Guzman et al, 1989;Magnuson et al, 1990;Sullivan et al, 1991;Kavaliers & Colwell, 1993;Demichel et al, 1993). Pharmacological studies have shown that intracerebroventricular (i.c.v.)…”

Section: Introductionmentioning

confidence: 99%

Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analogues

Gouardères

Jhamandas

Sutak

et al. 1996

British J Pharmacology

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1 Neuropeptide FF (NPFF) has been shown to produce antinociceptive effects and enhance morphineinduced antinociception after intrathecal (i.t.) injection. In this study, the spinal effects of two NPFF analogues, [D-Tyr',(NMe) (11 nmol 5 The results of this study show that spinal ,-and 6-opioid receptors play a role in antinociception produced by NPFF analogues. These results also suggest a role for NPFF in modulation of nociceptive signals at the spinal level.

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Elevation of arterial pressure in rats by two new vertebrate peptides FLF QPQRF-NH2 and AGE GLSSPFWSLAAPQRF-NH2 which are immunoreactive to FMRF-NH2 antiserum

Cited by 108 publications

References 10 publications

Neuropeptide FF distribution in the human and rat forebrain: A comparative immunohistochemical study

Neuropeptide FF distribution in the human and rat forebrain: A comparative immunohistochemical study

Localization of FMRFamide-Like Immunoreactivity in the Brain of the Viviparous Skink <i>(Chalcides chalcides)</i>

Role of opioid receptors in the spinal antinociceptive effects of neuropeptide FF analogues

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