Elevation of factor VII activity and mass in coronary artery disease of varying severity

Suzuki, Toshikazu; Yamauchi, Kazunobu; Matsushita, Tadashi; Furumichi, Takeo; Furui, Hirohiko; Tsuzuki, Jitsuki; Saito, Hidehiko

doi:10.1002/clc.4960140907

Cited by 48 publications

(21 citation statements)

References 21 publications

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“…Specifically, these differences, which may also reflect factor VII proteolysis in vivo, were only significant for patients with double-and triple-vessel disease. Plasmas of the patients with double-and triple-vessel disease also had significantly higher concentrations of thrombin-antithrombin III than age-matched controls and patients with single-vessel disease (Suzuki et al, 1991).…”

Section: Discussionmentioning

confidence: 85%

Age‐related changes in factor VII proteolysis in vivo

et al. 1996

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Previous studies have reported that pre-operative plasmas of patients over the age of 40 years who developed post-operative deep vein thrombosis (DVT) had approximately twice the amount of proteolysed factor VII found in plasmas of patients in whom prophylaxis with heparin or low M(r) heparin was successful. These and other studies also reported higher concentrations of thrombin-antithrombin III in pre- and post-operative plasmas of patients who developed post-operative thrombosis than in plasmas of patients in whom prophylaxis was successful. Whether the extent of factor VII proteolysis seen in the patients who developed post-operative DVT is related to the severity of their disease or age is not known. This report investigated age-related changes in the concentrations of total factor VII protein, factor VII zymogen, factor VIIa, tissue factor pathway inhibitor, thrombin-antithrombin III, and prothrombin fragment 1 + 2 in normal plasmas and the relationships between these parameters. With the exception of thrombin-antithrombin III, statistically significant increases in the concentrations of these parameters with age were found. Additionally, the differences between the concentrations of total factor VII protein and factor VII zymogen, an index factor VII proteolysis in vivo, were statistically significant only for individuals over age 40. Using linear regression analysis, a significant correlation was found to exist between the concentrations of plasma factor VIIa and prothrombin fragment 1 + 2. Since factor VIIa-tissue factor probably initiates coagulation in vivo, we hypothesize that the elevated plasma factor VIIa (reflecting a less tightly regulated tissue factor activity and therefore increased thrombin production in vivo) accounts for the high risk for post-operative thrombosis seen in individuals over the age of 40.

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Section: Discussionmentioning

confidence: 85%

Age‐related changes in factor VII proteolysis in vivo

et al. 1996

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“…Hemostatic risk factors have been suggested to play a causative role in the development of atherosclerosis. 5,6,23,24,[55][56][57][58][59] In addition, they may be markers of inflammation and endothelial dysfunction. 60 High plasma concentrations of fibrinogen, vWF, and FVII may also precipitate coronary events by enhancing procoagulant activity and reducing fibrinolytic defenses in the presence of a disrupted intracoronary plaque.…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic Status and Determinants of Hemostatic Function in Healthy Women

Wamala

Murray

Horsten

et al. 1999

ATVB

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Abstract-Hemostatic factors are reported to be associated with coronary heart disease (CHD). Socioeconomic status (SES) is 1 of the determinants of the hemostatic profile, but the factors underlying this association are not well known.Our aim was to examine determinants of the socioeconomic differences in hemostatic profile. Between 1991 and 1994, we studied 300 healthy women, aged 30 to 65 years, who were representative of women living in the greater Stockholm area. Fibrinogen, factor VII mass concentration (FVII:Ag), activated factor VII (FVIIa), von Willebrand factor (vWF), and plasminogen activator inhibitor-1 (PAI-1) were measured. Educational attainment was used as a measure of SES. Key Words: hemostatic function Ⅲ life style Ⅲ psychosocial stress Ⅲ socioeconomic status Ⅲ women H emostatic factors have been reported to be associated with coronary heart disease (CHD) morbidity 1-10 and mortality 11,12 in both men and women. Fibrinogen, factor VII, and von Willebrand (vWF) are coagulation factors that may increase the likelihood of atherothrombotic diseases, whereas plasminogen activator inhibitor-1 (PAI-1) is the rapid inhibitor of the endogenous fibrinolytic enzyme system. Fibrinogen may contribute to CHD by influencing the progression of coronary atherosclerosis 2,13,14 as well as by precipitating the formation of occlusive thrombus. 15,16 vWF and PAI-1 have been suggested to be associated with carotid atherothrombotic diseases 17 and to be related to recurrent myocardial infarction (MI). 7 In particular, vWF has been related to both recurrent MI and death in patients who survived a first MI. 8,9,11 Activated factor VII (FVIIa) has been reported to be a useful index of thrombin production during coagulation. 18 A social gradient in CHD has been found in both men and women, the risk of heart attack being higher in low socioeconomic strata. Educational attainment is the most consistent and reliable socioeconomic status (SES) measure that is associated with CHD. 19 Among the hemostatic factors, fibrinogen has received greatest attention, particularly in men. Inverse relations with education have been reported. 5,20 -22 In the Atherosclerosis Risk in Communities (ARIC) Study, a univariate association between low education and elevated levels of coagulant factor FVII (FVII:C) was observed in both men and women. 23 In contrast, an educational gradient in vWF, FVIIa, and PAI-1 has not been well documented. Although levels of hemostatic factors have been reported to be more elevated in women than in men, 1,5,6,21,23,24 [3][4][5][6][7][8][9][10][11][12][13][14][15][16]18,19,23,24,28,29 a sedentary life style, 23,30 obesity, 4,5,17,23,30,31 low alcohol consumption, 23,24,31 poor lipid profile, 1,3-5,20,23,30 hypertension, 3,4,23,30 social isolation, 29 and psychosocial job stress. [32][33][34] The main objective of this study was to investigate the association between SES and hemostatic profile and to assess the contribution of other cardiovascular risk factors to this association. Educational attainment was use...

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“…Elevated plasma fVII coagulant activity (fVII:C) or elevated levels of circulating fVIIa have also been described with angina pectoris, transient ischemic attacks, diabetes, uremia, and peripheral vascular disease (Broadhurst et al ., 1990; Carvalho de Sousa et al ., 1988; Cortellaro et al ., 1992; Hoffman et al ., 1988; Hoffman et al ., 1989; Kario et al ., 1993; Kario et al ., 1994; Kario et al ., 1995; Orlando et al ., 1987; Suzuki et al ., 1991). In contrast, some studies have failed to find a relationship between fVII levels and thrombotic disease (Hultin, 1991; Grant, 2003).…”

Section: Tf:viia In Diseasementioning

confidence: 99%

How it all starts: Initiation of the clotting cascade

Smith

Travers

Morrissey

2015

Critical Reviews in Biochemistry and Molecular Biology

387

334

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The plasma coagulation system in mammalian blood consists of a cascade of enzyme activation events in which serine proteases activate the proteins (proenzymes and procofactors) in the next step of the cascade via limited proteolysis. The ultimate outcome is the polymerization of fibrin and the activation of platelets, leading to a blood clot. This process is protective, as it prevents excessive blood loss following injury (normal hemostasis). Unfortunately, the blood clotting system can also lead to unwanted blood clots inside blood vessels (pathologic thrombosis), which is a leading cause of disability and death in the developed world. There are two main mechanisms for triggering the blood clotting, termed the tissue factor pathway and the contact pathway. Only one of these pathways (the tissue factor pathway) functions in normal hemostasis. Both pathways, however, are thought to contribute to thrombosis. An emerging concept is that the contact pathway functions in host pathogen-defenses. This review focuses on how the initiation phase of the blood clotting cascade is regulated in both pathways, with a discussion of the contributions of these pathways to hemostasis versus thrombosis.

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Elevation of factor VII activity and mass in coronary artery disease of varying severity

Cited by 48 publications

References 21 publications

Age‐related changes in factor VII proteolysis in vivo

Age‐related changes in factor VII proteolysis in vivo

Socioeconomic Status and Determinants of Hemostatic Function in Healthy Women

How it all starts: Initiation of the clotting cascade

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