Elevation of hepatic autophagy and antioxidative capacity by endurance exercise is associated with suppression of apoptosis in mice

Kwon, Insu; Song, Wankeun; Jang, Yong-Chul; Choi, Myung Dong; Vinci, Debra M.; Lee, Youngil

doi:10.1016/j.aohep.2019.08.010

Cited by 25 publications

(26 citation statements)

References 66 publications

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“…Hepatic autophagy activation during or after exercise stimulus is necessary for the recycling of cellular components and the elimination of damaged proteins [52]. In contrast to our data, Kwon et al [53] verified that five days of moderate-intensity exercise decreased the protein levels of p62 in the liver of male C57BL/6 mice. Kristensen et al [52] described that 60 min of running at 15 m/min and 10 degrees of inclination were not able to modulate the protein contents of p62 in the liver of wild-type mice.…”

Section: Discussioncontrasting

confidence: 99%

The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples

et al. 2020

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The present study verified the responses of proteins related to the autophagy pathway after 10 h of fast with resistance exercise and protein ingestion in skeletal muscle and liver samples. The rats were distributed into five experimental groups: control (CT; sedentary and without gavage after fast), exercise immediately (EXE-imm; after fast, rats were submitted to the resistance protocol and received water by gavage immediately after exercise), exercise after 1 h (EXE-1h; after fast, rats were submitted to the resistance protocol and received water by gavage 1 h after exercise), exercise and supplementation immediately after exercise (EXE/Suppl-imm; after fast, rats were submitted to the resistance protocol and received a mix of casein: whey protein 1:1 (w/w) by gavage immediately after exercise), exercise and supplementation 1 h after exercise (EXE/Suppl-1h; after fast, rats were submitted to the resistance protocol and received a mix of casein: whey protein 1:1 (w/w) by gavage 1 h after exercise). In summary, the current findings show that the combination of fasting, acute resistance exercise, and protein blend ingestion (immediately or 1 h after the exercise stimulus) increased the serum levels of leucine, insulin, and glucose, as well as the autophagy protein contents in skeletal muscle, but decreased other proteins related to the autophagic pathway in the liver. These results deserve further mechanistic investigations since athletes are combining fasting with physical exercise to enhance health and performance outcomes.

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Section: Discussioncontrasting

confidence: 99%

The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples

et al. 2020

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“…Previous investigations have described the positive effects of endurance exercise on liver fat reduction by activating AMPK and autophagy pathway in diet-induced obese mice [ 26 , 27 ]. Other authors have verified hepatic autophagy induction after endurance exercise in mice fed with a standard chow diet [ 8 , 9 ]. However, these studies focused only on the acute responses of the endurance exercise in autophagy machinery.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, other tissues are also impacted by exercise and exhibit the necessary adaptations to improve the entire metabolism [ 7 ]. Both the heart and liver have the autophagy pathway activated in response to exercise [ 8 , 9 , 10 , 11 ]. However, almost all available findings are related only to the endurance exercise model.…”

Section: Introductionmentioning

confidence: 99%

Moderate, but Not Excessive, Training Attenuates Autophagy Machinery in Metabolic Tissues

Rocha

Pinto

Morais

et al. 2020

IJMS

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The protective effects of chronic moderate exercise-mediated autophagy include the prevention and treatment of several diseases and the extension of lifespan. In addition, physical exercise may impair cellular structures, requiring the action of the autophagy mechanism for clearance and renovation of damaged cellular components. For the first time, we investigated the adaptations on basal autophagy flux in vivo in mice’s liver, heart, and skeletal muscle tissues submitted to four different chronic exercise models: endurance, resistance, concurrent, and overtraining. Measuring the autophagy flux in vivo is crucial to access the functionality of the autophagy pathway since changes in this pathway can occur in more than five steps. Moreover, the responses of metabolic, performance, and functional parameters, as well as genes and proteins related to the autophagy pathway, were addressed. In summary, the regular exercise models exhibited normal/enhanced adaptations with reduced autophagy-related proteins in all tissues. On the other hand, the overtrained group presented higher expression of Sqstm1 and Bnip3 with negative morphological and physical performance adaptations for the liver and heart, respectively. The groups showed different adaptions in autophagy flux in skeletal muscle, suggesting the activation or inhibition of basal autophagy may not always be related to improvement or impairment of performance.

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“…Exercise is a potential inducer of autophagy in liver, both in acute and chronic exercises (Kwon et al, 2020;Pi et al, 2019). Exercise has been known as a preventive strategy against NAFLD, because exercise can protect the liver by inducing molecular processes to help regulate hepatic metabolism, mainly lipid metabolism (Trefts et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Effects of Moringa Leaf Extract and Moderate Intensity Exercise on Histopathological Appearance and Autophagy Gene Expression

Gunadi

Jatnika

Astrid

et al. 2021

J. pendidik. jasmani olahraga

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The prevention of liver disease could be conducted through preventive strategies, such as antioxidants and exercise. Moringa leaf extract has substances that could act as antioxidant, while exercise is also known protecting the liver from disease by changing hepatic metabolism and autophagy. This study aimed to investigate the effect of moringa leaf extract and moderate intensity exercise on histopathological appearance and autophagy gene expression of wistar rat liver. The method used in this study was animal experiment using 24 male wistar rats divided into 4 groups, including control group, moringa group, exercise group, and moringa + exercise group. Moringa leaf extract was given in low dose (5.7 mg/kgW) per oral, 5 times a week, for 4 weeks. Meanwhile, the 20 m/minute treadmill exercise was given for 30 minutes per day, 5 times a week, for 4 weeks. Results showed a significant change on histopathological scoring in exercise group (p=0.011) compared to control group. Increased autophagy gene expression was found in moringa + exercise group compared to control group (LC3 0.90 fold; p62 0.87 fold). In summary, this study presented that moderate intensity exercise induced changes on histopathological appearance of wistar rat liver that might be associated with physiological inflammation. Moringa, with its antioxidant properties, combined with increased autophagy might improve histopathological changes in moringa + exercise group.

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Elevation of hepatic autophagy and antioxidative capacity by endurance exercise is associated with suppression of apoptosis in mice

Cited by 25 publications

References 66 publications

The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples

The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples

Moderate, but Not Excessive, Training Attenuates Autophagy Machinery in Metabolic Tissues

Effects of Moringa Leaf Extract and Moderate Intensity Exercise on Histopathological Appearance and Autophagy Gene Expression

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