Elevation of IgE in HIV-infected subjects: A marker of poor prognosis

Israël‐Biet, Dominique; Labrousse, F; Jm, Tourani; Sors, H.; Andrieu, J. M.; Even, P

doi:10.1016/s0091-6749(05)80042-9

Cited by 123 publications

(53 citation statements)

References 35 publications

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“…High serum IgE in individuals with AIDS were seen at the beginning of the epidemic and confirmed years later by other studies (63)(64)(65)(66)(67)(68)(69). Some studies have found a relationship between high IgE levels and CD4 + T lymphocyte count < 300 cells/ mm 3 (64)(65)67).…”

Section: Discussionsupporting

confidence: 57%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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This study applied a socioeconomic questionnaire designed to evaluate the frequency of intestinal parasites and characterize epidemiological, nutritional, and immunological variables in 105 HIV/AIDS patients -with and without parasitic infections, attending the Day Hospital in Botucatu, UNESP, from 2007 to 2008. Body mass index was calculated and the following tests performed: parasitological stool examinations; eosinophil, IgE, CD4 + T and CD8 + T lymphocyte cell counts; albumin test; viral load measure; and TNF-α, IFN-γ, IL-2, IL-5 and IL-10 cytokine levels. Results were positive for parasitic intestinal infections in 12.4% of individuals. Most patients had good socioeconomic conditions with basic sanitation, urban dwellings, treated water supply and sewage, good nutritional and immunological status and were undergoing HAART. Parasites were found at the following frequencies: Entamoeba -five patients (38.5%), Giardia lamblia -four (30.7%), Blastocystis hominis -three (23.0%), Endolimax nana -two (15.4%), and Ascaris lumbricoides -one (7.7%). There were no significant differences between the two groups for eosinophils, albumin, IgE, CD4 + T and CD8 + T lymphocytes, INF-γ, IL-2, or IL-10. Most patients also showed undetectable viral load levels. Significant differences were found for TNF-α and IL-5. These results show the importance of new studies on immunodeficient individuals to increase understanding of such variables.

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Section: Discussionsupporting

confidence: 57%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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“…However, there are few reports on the IgE levels of HIV infected patients. Some studies suggest that serum levels of IgE in these patients are inversely correlated with the number of CD 4+ T cells as well as the HIV viral load [1,2]. Ferrazzi et al measured serum IgE levels in 65 HIV-infected patients and reported that the mean IgE level in patients whose CD 4+ T cell count was < 2001µl was greater than that in patients whom the number was >2004L1 [3].…”

mentioning

confidence: 99%

“…Furthermore, in HIV-infected patients who show high serum IgE levels, our case and the data (Figure 1) suggest that serum IgE levels may serve as a more useful parameter (as well as HIV viral load) of HIV-related diseases activities than is generally appreciated. Finally, we are now planning to investigate the relationship between viral load and other possible parameters other than serum IgE levels, such as IgG and IgA in HIV-infected patients, although serum IgE levels are known to be more strongly related to the CD 4+ T cell count than in other immunoglobulin classes [2].…”

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confidence: 99%

The Relationship between IgE level and HIV Viral Load

et al. 2002

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“…HIV ile enfekte kişilerde yardımcı T hücrelerinde (CD4) progressif azalma ve T hücre disfonksiyonu olmaktadır. IgE yüksekliğine eozinofili de eşlik etmektedir (11,12). Bir çalışmada HIV enfekte çocuklarda HIV enfeksiyonunun aktif hale gelmesinden agreve olmasından bağımsız olarak total IgE yüksekliği tespit edilmiştir (13).…”

Section: -Sekonder İmmün Yetmezli̇kler A) Hivunclassified

High Serum Immunoglobulin E Levels are not Always Due to an Allergy: Hints for Evaluation of the Etiology

Arslan¹,

Çalışkaner²

2017

Asthma Allergy Immunol

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ÖZTıp biliminin her geçen gün ilerleme kaydediyor olması, hekimlikte spesifik konularda ihtisas yapma gerekliliğini doğurmuştur. Günümüzde özellikle dahili branşlarda ve onu takiben cerrahi branşlarda çok sayıda yeni bilim dalları kurulmuştur.Ancak bazı konular vardır ki, hekimler hangi uzmanlık alanına yönlenmiş olurlarsa olsunlar pek bir değişikliğe uğramadan kalır. Bunlara en iyi örnek; eozinofil sayısı yüksek ya da IgE düzeyi yüksek hastalarda, birinci sıradaki ön tanının "ALLERJİ" olmasıdır.Bu yazıda, yüksek IgE düzeyi ile gelen hastalarda ayırıcı tanı konusu ele alınmakta, IgE yüksekliğinin nedenleri, ne zaman araştırılmalı, IgE yüksekliğinin araştırılmasını şekillendirecek klinik bulgular ve değerlendirmeleri konularına değinilmektedir. ABSTRACTThe constant progress of medical science has made it necessary to specialize on various fields. There are now many new disciplines in internal medicine and surgery.However, some beliefs continue with little change despite this specialization. A good example to these is considering allergy first in patients with significant eosinophilia or high IgE levels.In this article, we discuss the differential diagnosis of high IgE levels with information on the causes, when it should be investigated, and the relevant clinical findings and evaluations. Allerjik antikor olarak da adlandırılan IgE; birçok allerjik hastalığın patogenezinde rol oynadığı gibi, sağlıklı bir yanıt olarak hümoral hafıza cevabının önemli bir başlatıcısıdır. IgE parazitik hastalıklarla (özellikle helmint ve protozoa) savunmasında ve antitümör immünitesinde anahtar mediatördür (1).

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Elevation of IgE in HIV-infected subjects: A marker of poor prognosis

Cited by 123 publications

References 35 publications

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

The Relationship between IgE level and HIV Viral Load

High Serum Immunoglobulin E Levels are not Always Due to an Allergy: Hints for Evaluation of the Etiology

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