Elevation of Multiple Humoral Substances in Zollinger-Ellison Syndrome

Block, Melvin A.

doi:10.1001/archsurg.1969.01340120082012

Cited by 14 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…T h e pertinent clinical information and other data of these cases are summarized in Table 1. Cases [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] represented UTP, i.e. they exhibited various manifestations of the Zollinger-Ellison syndrome, principally recurrent peptic ulceration of the u p per gastrointestinal tract and marked gastric acid hyper-secretion.…”

Section: Conventional Light Microscopymentioning

confidence: 99%

The human pancreatic islet cells and their tumors.II. Ulcerogenic and diarrheogenic tumors

Greider

Rosaí

McGuigan

1974

Cancer

View full text Add to dashboard Cite

A comparative histologic examination of hematoxylin‐eosin stained sections of 34 ulcerogenic tumors of the pancreas (UTP), 5 diarrheogenic tumors of die pancreas (DTP), 13 beta cell tumors, and 4 alpha cell tumors revealed two correlative features: all tumors characterized by a gyriform pattern of growth throughout the lesion were either of alpha or beta cell origin, and all but 1 of the tumors containing glandular formations were of either UTP or DTP type. No differential morphological features were found between the tumors which gave rise to metastases and those which did not. A combination of histochemical, ultrastructural, and biochemical studies easily differentiated UTP‐DTP from alpha‐beta cell tumors in most instances. Histochemical stains of 18 UTP and 4 DTP revealed that except for 1 DTP the tumors did not stain with reagents that differentiated normal islet cells. One of the 4 UTP tested gave a positive reaction with a direct immunofluorescent technique using fluoresceinated antibodies to gastrin. Ultrastructurally, all 22 tumors contained secretory granules; in most tumor cells these granules had a diameter range of 150–200 nm, but in others they were pleomorphic and larger (150–360 nm). In this study no morphological, histochemical, or ultrastructural differences were observed between UTP and DTP neoplasms.

show abstract

Section: Conventional Light Microscopymentioning

confidence: 99%

The human pancreatic islet cells and their tumors.II. Ulcerogenic and diarrheogenic tumors

Greider

Rosaí

McGuigan

1974

Cancer

View full text Add to dashboard Cite

show abstract

Carcinoid islet cell tumor of the duodenum and associated multiple carcinoid tumors of the ileum.An electron microscopic study

Weichert

Roth

Harkin

1971

Cancer

View full text Add to dashboard Cite

Light and electron microscopic studies were done on a carcinoid‐islet cell tumor of the duodenum and 8 carcinoid tumors of the ileum which were surgically excised from a patient with achalasia and a duodenal ulcer. By light microscopy, the duodenal tumor resembled both an islet cell tumor and a carcinoid of the type found in tissues of foregut origin; the ileal tumors had the typical characteristics of carcinoids of midgut origin. On electron microscopy, some cells of the duodenal tumor contained small round granules, which resemble the delta cell granules of the normal islets of Langerhans and the granules present in gastric carcinoid tumors. Other cells in the duodenal tumor contained large granules of low electron density. The ileal tumors contained polymorphic elongated secretory granules that were believed to contain serotonin. The association of this duodenal tumor, which had morphological characteristics of both a carcinoid and an islet cell tumor, with multiple carcinoids of the ileum and with a duodenal ulcer can be interpreted as giving further support to the concept that such duodenal tumors are related both to carcinoid and islet cell tumors.

show abstract

The diagnosis and treatment of gastrinoma and Zollinger-Ellison syndrome

McCarthy¹

1984

Diagnosis and Management of Endocrine-Related Tumors

View full text Add to dashboard Cite

Elevation of Multiple Humoral Substances in Zollinger-Ellison Syndrome

Cited by 14 publications

References 25 publications

The human pancreatic islet cells and their tumors.II. Ulcerogenic and diarrheogenic tumors

The human pancreatic islet cells and their tumors.II. Ulcerogenic and diarrheogenic tumors

Carcinoid islet cell tumor of the duodenum and associated multiple carcinoid tumors of the ileum.An electron microscopic study

The diagnosis and treatment of gastrinoma and Zollinger-Ellison syndrome

Contact Info

Product

Resources

About