Elevation of Serum C-Reactive Protein Levels Is Associated with Obesity in Boys

Abstract

This study aimed to reveal the relationships among C-reactive protein (CRP), obesity, blood pressure (BP), and serum lipids in children. Eighty-six obese and 58 non-obese boys aged an average of 11.2 years were examined. Serum CRP levels were measured by high sensitivity latex turbidimetric immunoassay and subjects with CRP levels below 0.3 mg/dl were adopted. Comparisons of serum CRP levels, BP, and serum than 10% over the last two decades (2) and this also constitutes a serious public health problem. It is well known that obesity is often associated with metabolic syndromes such as HT, DM, and dyslipidemia. Thus the prevalence of obesityrelated metabolic syndromes can be expected to increase in the near future (3, 4). Clearly, a strategy for preventing obesity will also be needed in children.Recently, many markers of AS have been found, and these are expected to serve as useful indices of prevention and early intervention of coronary events. C-reactive protein (CRP), one of these markers, has been used as an acute phase reac-

Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity

“…Previous studies have shown similar results in young overweight and obese individuals [7,8,[11][12][13][14]18]. However, the values of hs-CRP obtained in our study are higher as compared to some previous observations [11]. In the study by Hiura et al, mean CRP values were 0.33 and 1.20 mg/L in non-obese and obese groups respectively; this may be due to exclusion of children with high hs-CRP values in the obese group assuming the possibility of acute infection.…”

“…Previous studies have shown similar results in young overweight and obese individuals [7,8,[11][12][13][14]18]. However, the values of hs-CRP obtained in our study are higher as compared to some previous observations [11].…”

“…As many as 23 out of 109 obese children were excluded in that study because of hsCRP values of > 3 mg/L [11]. The authors of the study did discuss the possibility that hsCRP elevation was not necessarily due to acute infection in obese children who were excluded [11]. The hsCRP levels in our study were also higher as compared to those found in a similar study from South India [19].…”

“…In the study by Hiura et al, mean CRP values were 0.33 and 1.20 mg/L in non-obese and obese groups respectively; this may be due to exclusion of children with high hs-CRP values in the obese group assuming the possibility of acute infection. As many as 23 out of 109 obese children were excluded in that study because of hsCRP values of > 3 mg/L [11]. The authors of the study did discuss the possibility that hsCRP elevation was not necessarily due to acute infection in obese children who were excluded [11].…”

“…High CRP levels also correlate well with other parameters of MS [10]. Majority of the previous studies showing raised CRP levels in obese children are from the developed countries [4][5][6][7][8][9][11][12][13][14]. The need to generate data from the developing countries is even more in view of the recent observations and recommendations for diagnosis of obesity and MS for Asian Indians [15].…”