Elevation of serum prolactin levels in patients with pemphigus vulgaris: A novel finding with practical implications

Fallahzadeh, Mohammad Kazem; Lashkarizadeh, Hamid; Kamali-Sarvestani, Eskandar; Namazi, Mohammad Reza

doi:10.1016/j.jaad.2009.09.051

Cited by 7 publications

(9 citation statements)

References 5 publications

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“…reported the presence of a significantly higher serum concentration of prolactin among 24 patients with pemphigus compared to healthy controls. They also found a positive correlation between serum total prolactin levels and the extent of body surface involvement . In another study on 20 patients, Helmy et al .…”

Section: Discussionmentioning

confidence: 85%

“…Higher levels of total prolactin in patients with pemphigus have been previously reported only in two studies . Fallahzade et al .…”

Section: Discussionmentioning

confidence: 91%

“…[9][10][11] Higher levels of total prolactin in patients with pemphigus have been previously reported only in two studies. 12 Fallahzade et al reported the presence of a significantly higher serum concentration of prolactin among 24 patients with pemphigus compared to healthy controls. They also found a positive correlation between serum total prolactin levels and the extent of body surface involvement.…”

Section: Discussionmentioning

confidence: 99%

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Evaluating serum prolactin and serum dehydroepiandrosterone sulfate levels in patients with pemphigus

et al. 2016

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Section: Discussionmentioning

confidence: 85%

“…Higher levels of total prolactin in patients with pemphigus have been previously reported only in two studies . Fallahzade et al .…”

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Evaluating serum prolactin and serum dehydroepiandrosterone sulfate levels in patients with pemphigus

et al. 2016

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“…In a cross-sectional study by Fallahzadeh et al in 2010, mean PRL levels of PV patients were significantly higher than those in the control group ( p = .048), and there was a positive correlation between serum prolactin levels and extent of disease (Fallahzadeh et al, 2010). …”

Section: Discussionmentioning

confidence: 92%

“…Other studies have shown a correlation between PRL level and PV (Barzegari et al, 2004, Fallahzadeh et al, 2010, Helmy et al, 2013, Kavala et al, 2006). …”

Section: Introductionmentioning

confidence: 82%

Evaluation of prolactin levels in patients with newly diagnosed pemphigus vulgaris and its correlation with pemphigus disease area index

Lajevardi

Hallaji

Daneshpazhooh

et al. 2016

International Journal of Women's Dermatology

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BackgroundProlactin is a hormone; in addition to it known roles, it has immunomodulatory effects on lymphocytes maturation and immunoglobulins production. Hyperprolactinemia has been demonstrated in various autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes mellitus, and Graves’ disease. In view of the prolactin immunomodulatory roles, studying prolactin levels in pemphigus as an autoimmune blistering disease may introduce new ways of understanding disease etiology and developing treatment strategies.ObjectiveOur purpose was to determine the prolactin levels in patients with newly diagnosed pemphigus vulgaris and study its correlation with pemphigus disease area index.LimitationOur study was limited by the lack of a control group.MethodsIn this cross-sectional study, prolactin and anti-desmoglein 1 and 3 autoantibodies levels were measured in 50 patients with newly diagnosed pemphigus vulgaris in Razi Dermatology Hospital. Pemphigus severity and extent was estimated using the Pemphigus Disease Area Index.ResultsOf the 50 patients, 18 were male and 32 were female with a mean age of 41.56 ± 13.66 years. Mean prolactin (PRL) level was 15.60 ± 11.72 ng/ml (10.68 in males and 18.37 in females). Mean anti-desmoglein 1 and 3 autoantibodies were 135.8 ± 119.8 and 245.8 ± 157.4 U/ml, respectively. Eleven out of 50 patients had a higher than normal prolactin range. No relation was found between prolactin level and disease activity (p = .982). Also, correlation studies show no relation between prolactin and anti-desmoglein 1 and 3 autoantibodies levels (respectively, p = .771 and .738). In comparing the extent of the disease between the two groups with normal and high prolactin, paired t-test showed no significance (p = .204).ConclusionIn our study, 22% of patients had hyperprolactinemia, which was greater among females. The highest PRL level was detected in mucocutaneous group. Although serum PRL levels were higher in patients with a greater Pemphigus Disease Area Index, it did not reach statistical significance.

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