Elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and beta-2-microglobulin in Sjögren's syndrome

Krejsek, Jan; Slezák, Radovan; Kopecký, O; Derner, Václav; Andrýs, Ctirad

doi:10.1007/bf02247843

Cited by 9 publications

(6 citation statements)

References 37 publications

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“…The elevated levels of soluble adhesion molecules are found in the serum of patients with various inflammatory diseases and may provide some useful diagnostic or prognostic information (7). The serum or plasma levels of soluble forms of adhesion molecules are reported to be elevated in patients with various immunopathological diseases such as atopic dermatitis and psoriasis (6), vasculitis and scleroderma (5), Sj(gren syndrome (11,12), atherosclerosis (2,3), systemic lupus erythematosus (22) as well as in malignancies (1,23) and in infectious disorders such as septic shock (18).…”

Section: Discussionmentioning

confidence: 99%

Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1 and sE-Selectin) in Healthy School Aged Children and Adults

Andrýs

Pozler

Krejsek

et al. 2000

Acta Med. (Hradec Kralove, Czech Repub.)

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The aim of this study was to map normal levels of serum soluble isoforms of adhesion molecules in relation to age and sex in the group of school-aged children. sICAM-1, sVCAM-1 and sE-selectin were determined in the group of 158 normal children subdivided into two subgroups; 6-10 years (68 children, median age 8 years) and 11-15 years (90 children, median age 12 years) and in 70 normal adult blood donors (25 females and 45 males, median age 46 years). The levels of sICAM-1 and sE-selectin fell down significantly over the age range 6-15 years, while the level of sVCAM-1 was remained. Age-related normal ranges were established using correlation analysis and were expressed as the 5%-95% percentiles intervals: sICAM-1 206.8-486.8 ng/ml, sE-selectin 36.7-153.2 ng/ml in the group of 6-10 years old children, sICAM-1 184.1-354.0 ng/ml, sE-selectin 29.9-114.1 ng/ml in group of 11-15 years old children. The levels of sVCAM-1 were 359.6-822.0 ng/ml and were constant within the examined age interval from 6 to 15 years. The influence of sex was also assayed and it was not statistically significant in any age category tested. Normal ranges of sICAM-1 (60.2-218.4 ng/ml), sE-selectin (8.3-116.9 ng/ml) and sVCAM-1 (338.0-1148.0 ng/ml) were established for adult population of healthy blood donors using the same methods.

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Section: Discussionmentioning

confidence: 99%

Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1 and sE-Selectin) in Healthy School Aged Children and Adults

Andrýs

Pozler

Krejsek

et al. 2000

Acta Med. (Hradec Kralove, Czech Repub.)

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“…Another evidence of lymphoproliferation in lung tissue comes from elevated beta-2-microglobulin that is released by lymphocytic tissue and elevated in serum from patients with pSS, particularly pulmonary pSS (58, 59). Lahdensuo and Korpela prospectively studied seventeen patients with pSS with no history of smoking to evaluate the correlation between pulmonary findings including chest CT and pulmonary function tests and serum beta-2-microglobulin as well as immunoglobulins including IgA, IgG, IgM.…”

Section: Pathogenesismentioning

confidence: 99%

Pulmonary Manifestations of Primary Sjögren's Syndrome: Underlying Immunological Mechanisms, Clinical Presentation, and Management

Gupta

Ferrada

2019

Front. Immunol.

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Pulmonary involvement in primary Sjögren's syndrome (pSS) is an understudied entity with important clinical implications. Its prevalence has been reported in up to 20% of pSS patients. Pulmonary manifestations of pSS are diverse with involvement of airway and/or lung parenchyma. Histopathology of lung lesions suggests a predominance of submucosal mononuclear cell infiltration consisting predominantly of CD4+ T cells. Current understanding of the pathophysiology of lung disease in pSS suggests a similar process driving the pulmonary process as those in the salivary glands, with epithelial cells playing a critical role in the initiation, maintenance, and symptomatology of the disease. Clinical manifestations of lung involvement in pSS are as varied as the underlying pathology and can be vague and non-specific, thus delaying diagnosis. Management options depend on the underlying pathology but are generally limited due to lack of systematic randomized controlled trials. This review helps summarize our current understanding of lung involvement in pSS.

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“…Johanssen et al (18) found hig- her levels of ICAM-1 in both serum and residual saliva of patients with primary SS in comparison with control. Recently, we have reported that serum levels of ICAM-1 is significantly higher in primary and secondary SS patients and in the case of secondary SS the level of sICAM-1 is correlated with the level of beta-2 microglobulin (20).…”

Section: Discussionmentioning

confidence: 91%

Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) and Neopterin in Patients with Sjögren's Syndrome

Andrýs¹,

Krejsek²,

Slezák³

et al. 1999

Acta Med. (Hradec Kralove, Czech Repub.)

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Sjögren's syndrome is a systemic autoimmune disease characterized by focal lymphocytic infiltration of the salivary and lacrimal glands. Expression and up-regulation of adhesion molecules and activation of cellular immune system is essential for the migration of inflammatory cells into tissues. Soluble forms of adhesion molecules sICAM-1, sVCAM-1, sE-selectin and neopterin were analyzed in serum of 17 patients with primary Sjögren's syndrome and 11 patients with secondary Sjögren's syndrome together with 26 age-matched healthy blood donors. There were significantly higher serum concentrations (mean ± 1SD) of sICAM-1 (362.0 ± 67.9 ng/ml, p<0.001), sE-selectin (78.7 ± 28.1 ng/ml, p<0.001) and neopterin (17.9 ± 6.4 nmol/l, p<0.001) in primary Sjögren's syndrome patients in comparison to control group (sICAM-1: 128.3 ± 46.9 ng/ml, sE-selectin: 46.3 ± 39.5 ng/ml, and neopterin: 7.6 ± 2.3 nmol/l). Sera from patients with secondary Sjögren's disease contained significantly higher levels of sICAM-1 (356.0 ± 62.4 ng/ml, p<0.001), sE-selectin (65.5 ± 27.0 ng/ml, p<0.05), and neopterin (18.8 ± 9.8 nmol/l, p<0.001) in comparison with control group. There were no significant differences between patients with primary and secondary Sjögren's syndrome in any parameters tested. No statistically significant differences in serum levels of sVCAM-1 were found either in patients with primary or secondary SS compared to control group.

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Elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and beta-2-microglobulin in Sjögren's syndrome

Cited by 9 publications

References 37 publications

Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1 and sE-Selectin) in Healthy School Aged Children and Adults

Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1 and sE-Selectin) in Healthy School Aged Children and Adults

Pulmonary Manifestations of Primary Sjögren's Syndrome: Underlying Immunological Mechanisms, Clinical Presentation, and Management

Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) and Neopterin in Patients with Sjögren's Syndrome

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