Elevation of the adiponectin/leptin ratio in women with gestational diabetes mellitus after supplementation with alpha-lipoic acid

Aslfalah, Hadise; Jamilian, Mehri; Khosrowbeygi, Ali

doi:10.1080/09513590.2018.1519795

Cited by 24 publications

(15 citation statements)

References 27 publications

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“…The 14 excluded studies along with the reason of their exclusion are presented in Table S1 . Three studies were included in the systematic review but not in the quantitative synthesis because one did not provide necessary descriptive statistic measures [ 19 ], and in the two other studies the outcome measures did not match the predefined primary and secondary outcomes [ 20 , 21 ]. Finally, 16 studies of 1173 women with GDM, were included in the quantitative synthesis (meta-analysis).…”

Section: Resultsmentioning

confidence: 99%

The Effect of Dietary Supplements on Oxidative Stress in Pregnant Women with Gestational Diabetes Mellitus: A Network Meta-Analysis

et al. 2021

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Background: Gestational diabetes mellitus (GDM) exacerbates the oxidative stress status of the pregnant women. Τo improve the oxidative stress status, several therapeutic interventions have been suggested. The aim of this network meta-analysis is to assess the effect of different dietary supplements on the oxidative stress status in pregnant women with GDM. Methods: A network meta-analysis of randomized control trials was performed comparing the changes delta (Δ) in total antioxidant capacity (TAC) and concentration of malondialdehyde (MDA) as primary outcomes, following different therapeutic interventions with dietary supplements in pregnant women with GDM. Four electronic databases and grey literature sources were searched. The secondary outcomes were other markers of oxidative stress. Results: The meta-analysis included 16 studies of 1173 women with GDM. Regarding ΔTAC: probiotics and omega-3 with vitamin E were superior to placebo/no intervention. Regarding ΔMDA: vitamin D with calcium, omega-3, vitamin D, omega-3 with vitamin E, magnesium with zinc and calcium, and probiotics were superior to placebo/no intervention. Conclusions: Administration of dietary supplements in women with GDM can be helpful in limiting the oxidative stress which develop in these pregnancies.

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Section: Resultsmentioning

confidence: 99%

The Effect of Dietary Supplements on Oxidative Stress in Pregnant Women with Gestational Diabetes Mellitus: A Network Meta-Analysis

et al. 2021

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“…Overall, these data represent the first evidence that Myo is able to improve endothelial stress/damage in vascular cells by modulating inflammation and oxidative stress related to diabetes. These effects are comparable to the protective vascular action of LA, a molecule with well-known antioxidant effects that has demonstrated safety as well as beneficial effects on glycemia and liver enzymes as well as on lipid profiles and on adiponectin/leptin ratios in women affected by either GDM or polycystic ovary syndrome [ 8 , 27 , 30 , 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 95%

Myoinositol Reduces Inflammation and Oxidative Stress in Human Endothelial Cells Exposed In Vivo to Chronic Hyperglycemia

et al. 2021

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Myo-inositol (Myo) improves insulin resistance, glucose metabolism, and helps gestational diabetes (GDM) management. GDM is associated with a pro-inflammatory state and increased oxidative stress, which are both involved in vascular damage in diabetes. Our aim was to study Myo anti-inflammatory/antioxidant potential effects on an in vitro model of human umbilical vein endothelial cells (HUVECs). To this end, monocyte cell adhesion to HUVECs, adhesion molecule membrane exposure, and oxidative stress levels were determined in cells from control (C-) and GDM women treated during pregnancy either with diet only (GD-) or with diet plus Myo (GD+Myo). To deeply study the vascular effects of Myo, the same evaluations were performed in C- and GD-HUVECs following 48 h in vitro stimulation with Myo. Notably, we first observed that GD-HUVECs obtained from women assuming Myo supplementation exhibited a significantly decreased number of monocytes that adhered to endothelial cells, less adhesion molecule exposure, and lower intracellular reactive oxygen species (ROS) levels in the basal state as compared to GD-HUVECs obtained from women treated by diet only. This Myo anti-inflammatory/antioxidant effect was confirmed by 48 h in vitro stimulation of GD-HUVECs as compared to controls. Altogether, these results strongly suggest that Myo may exert protective actions against chronic inflammation induced by endothelial dysfunction in diabetes.

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“…Although triglycerides metabolism is prevalent in pregnant subjects, an excess level of triglycerides metabolism is a sign of gestational diabetes mellitus (GDM) (Aslfalah, Jamilian, & Khosrowbeygi, 2019; Aslfalah, Jamilian, Rafiei, & Khosrowbeygi, 2019). It was observed that daily administration of α‐LA (100 mg, 8 weeks) during pregnancy to patients suffering from GDM decreased insulin resistance and elevated adiponectin level (Aslfalah, Jamilian, & Khosrowbeygi, 2019; Bo et al, 2004) (Table 1).…”

Section: Clinical Trial Studiesmentioning

confidence: 99%

Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review

Najafi

Mehri

Rahbardar

2022

Phytotherapy Research

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Metabolic syndrome (MetS) is a multifactorial disease with medical conditions such as hypertension, diabetes, obesity, dyslipidemia, and insulin resistance. Alpha-lipoic acid (α-LA) possesses various pharmacological effects, including antidiabetic, antiobesity, hypotensive, and hypolipidemia actions. It exhibits reactive oxygen species scavenger properties against oxidation and age-related inflammation and refines MetS components. Also, α-LA activates the 5 0 adenosine monophosphate-activated protein kinase and inhibits the NFκb. It can decrease cholesterol biosynthesis, fatty acid β-oxidation, and vascular stiffness. α-LA decreases lipogenesis, cholesterol biosynthesis, low-density lipoprotein and very low-density lipoprotein levels, and atherosclerosis. Moreover, α-LA increases insulin secretion, glucose transport, and insulin sensitivity. These changes occur via PI3K/Akt activation. On the other hand, α-LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation. In this review, the most relevant articles have been discussed to determine the effects of α-LA on different components of MetS with a special focus on different molecular mechanisms behind these effects. This review exhibits the potential properties of α-LA in managing MetS; however, high-quality studies are needed to confirm the clinical efficacy of α-LA.

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Elevation of the adiponectin/leptin ratio in women with gestational diabetes mellitus after supplementation with alpha-lipoic acid

Cited by 24 publications

References 27 publications

The Effect of Dietary Supplements on Oxidative Stress in Pregnant Women with Gestational Diabetes Mellitus: A Network Meta-Analysis

The Effect of Dietary Supplements on Oxidative Stress in Pregnant Women with Gestational Diabetes Mellitus: A Network Meta-Analysis

Myoinositol Reduces Inflammation and Oxidative Stress in Human Endothelial Cells Exposed In Vivo to Chronic Hyperglycemia

Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review

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