Pregnancy is associated with significant, but reversible changes in thyroid function studies, which are among the most profound seen as a result of a normal physiologic state. The present study was carried out to find out alterations in thyroid function tests in each trimester in normal pregnant women as compared to non-pregnant women in Tabriz-lran. A case-control study designed with 229 normal pregnant women that randomly selected from the first (64 samples), the second (92 samples), and the third (73 samples) trimesters and 250 randomly selected non-pregnant healthy female controls. Age range in both groups was 16-40 years. Thyroid function tests carried out by measuring serum levels of thyroid stimulating hormone (TSH), free and total thyroxin (FT 4, TT4), and free and total triiodothyronine (FT 3, TT3) by commercially available radio immunoassay kits. We found that mean TT 4 increased progressively during pregnancy. Our study showed increasing in serum levels of TT 3 in the second trimester and then declining during the third trimester compared with non-pregnant women. We showed that FT 4 strongly decreased during the third trimester. Free T 3 showed declining in the second and third trimesters. Mean TSH did not show significant difference in each trimester compared with non-pregnant women. The thyroid function tests in pregnancy should be interpreted against gestational age-related reference intervals to avoid mis-interpretation of thyroid function during pregnancy.

The results of the current study had shown that after supplementation with 100 mg/day of CoQ for 12 weeks, serum values of FBS, HOMA-IR, TC, LDL-C and ferritin were decreased and values of HDL-C were increased in women with T2DM.

Patients with type 2 diabetes mellitus (T2DM) have been known to be suffering from coenzyme Q10 (CoQ10) deficiency which results in some complications in them. The purpose of this clinical trial study was to evaluate the effects of CoQ10 supplementation on serum values of adiponectin (A), leptin (L), 8-isoprostane, malondialdehyde (MDA), the A/L ratio in women with T2DM. Sixty-eight women with T2DM were enrolled in the current study and were randomly divided into drug (n = 34) and placebo (n = 34) groups who were consuming 100 mg CoQ10 and 100 mg cellulose acetate per day for 12 weeks, respectively. Measurements were performed at the beginning and after the intervention. Serum values of adiponectin (p = .001) and the A/L ratio (p = .001) were increased while values of leptin (p = .041), MDA (p = .023), 8-isoprostane (p = .004) were decreased significantly in drug group after intervention. This study had shown that CoQ10 supplementation in women with T2DM was effective in elevation of adiponectin and the A/L ratio and reduction of leptin, MDA and 8-isoprostane which could result in improving insulin resistance and modulating oxidative stress situation.

Introduction:Thi study aimed to determine the status of pruritus and its relation to dialysis adequacy and laboratory factors among hemodialysis patients in Shiraz dialysis centers so that appropriate interventions could be planned for promotion of the life quality. Materials and Methods:This is a cross-sectional study on the data collected from 141 patients selected by convenient sampling. We used a questionnaire, interview, and lab test for data collection. Data were analyzed using SPSS 11.5 software and appropriate tests. A p value=0.05 was considered as the significance level. Results:The mean age of our patients was 53±16 years, (82.3% were married), and 53.2% of them were male. Of these patients, 39.7% had pruritus and most of them (48.1%) reported they had pruritus in different times of the day. A significant correlation was found between dialysis adequacy and pruritus (p=0.029), and the correlation of pruritus and high sensitive-C-reactive protein (hs-CRP) was significantly positive (p=0.009). Conclusion:Pruritus is a common problem in haemodialysis patients and is significantly associated with dialysis adequacy and hs-CRP. The level of their quality of life could be enhanced by appropriate interventions.

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