Elevation of tissue α-tocopherol levels by conjugated linoleic acid in C57BL/6J mice is not associated with changes in vitamin E absorption or α-carboxyethyl hydroxychroman production

Chen, Wan-Hsuan; Li, Yi-Jen; Wang, Ming-Shyong; Kang, Zhi-Chyang; Huang, Huei-Ling; Shaw, Huey-Mei

doi:10.1016/j.nut.2011.04.006

Cited by 14 publications

(23 citation statements)

References 60 publications

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“…They found that neither absorption nor degradation of αT to αCEHC was affected by CLA supplementation. Induction of TTP mRNA and protein expression was demonstrated as the crucial factor for the improved vitamin E status in the CLA-fed mice (Chen et al, 2012). In the present study, in the CTR group, liver αT concentrations changed inversely over time compared with that of serum αT.…”

Section: Discussionsupporting

confidence: 50%

“…Liver vitamin E concentrations were 15-fold higher in CLA-fed mice than in control animals (Liao et al, 2008). The improved vitamin E status of CLA-treated animals might be due to the induction of TTP expression in the liver (Chen et al, 2012). An increase in longissimus muscle αT concentration as a result of feeding rumen-protected CLA was also recently reported in young Simmental heifers (Schlegel et al, 2012).…”

Section: Introductionsupporting

confidence: 51%

“…In support of this, Grebenstein et al (2014) recently reported that vitamin E metabolism, not TTP, is responsible for the selective retention of αT and discrimination against γT. Interestingly, Chen et al (2012) reported that the liver αT concentrations were 7 times higher in CLAsupplemented mice than in the control group. They found that neither absorption nor degradation of αT to αCEHC was affected by CLA supplementation.…”

Section: Discussionmentioning

confidence: 88%

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Tocopherols and tocotrienols in serum and liver of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation

Sadri

Dänicke

Meyer

et al. 2015

Journal of Dairy Science

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The fat-soluble vitamin E comprises the 8 structurally related compounds (congeners) α-, β-, γ-, and δ-tocopherol (with a saturated side chain) and α-, β-, γ-, and δ-tocotrienol (with a 3-fold unsaturated side chain). Little is known regarding the blood and liver concentrations of the 8 vitamin E congeners during the transition from pregnancy to lactation in dairy cows. We thus quantified tocopherols (T) and tocotrienols (T3) in serum and liver and hepatic expression of genes involved in vitamin E metabolism in pluriparous German Holstein cows during late gestation and early lactation and investigated whether dietary supplementation (from d 1 in milk) with conjugated linoleic acids (CLA; 100g/d; each 12% of trans-10,cis-12 and cis-9,trans-11 CLA; n=11) altered these compared with control-fat supplemented cows (CTR; n=10). Blood samples and liver biopsies were collected on d -21, 1, 21, 70, and 105 (liver only) relative to calving. In both groups, the serum concentrations of αT, γT, βT3, and δT3 increased from d -21 to d 21 and remained unchanged between d 21 and 70, but were unaffected by CLA. The concentrations of the different congeners of vitamin E in liver did not differ between the CTR and the CLA groups. In both groups, the concentrations of the vitamin E forms in liver changed during the course of the study. The hepatic mRNA abundance of genes controlling vitamin E status did not differ between groups, but α-tocopherol transfer protein and tocopherol-associated protein mRNA increased with time of lactation in both. In conclusion, the concentrations of vitamin E congeners and the expression of genes related to vitamin E status follow characteristic time-related changes during the transition from late gestation to early lactation but are unaffected by CLA supplementation at the dosage used.

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Section: Discussionsupporting

confidence: 50%

Section: Introductionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 88%

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Tocopherols and tocotrienols in serum and liver of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation

Sadri

Dänicke

Meyer

et al. 2015

Journal of Dairy Science

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“…In our previous study, a-tocopherol levels in the plasma, liver, and adipose tissue in mice were found to be dramatically increased by CLA (Chao et al, 2010), and we speculated that this might be related to the increased levels of hepatic a-TTP (Chao et al, 2010;Chen et al, 2012). The activities of hepatic catalase and glutathione peroxidase are also regulated by CLA (Chen et al, 2012).…”

Section: Introductionmentioning

confidence: 87%

“…The activities of hepatic catalase and glutathione peroxidase are also regulated by CLA (Chen et al, 2012). The commercial CLA used in most studies is an equimolar mix of cis-9, trans-11 CLA (c9t11 CLA) and trans-10, cis-12 CLA (t10c12 CLA).…”

Section: Introductionmentioning

confidence: 99%

trans-10,cis-12 Conjugated linoleic acid specifically increases tissue α-tocopherol mediated by PPARγ inhibition in mice

Wang¹,

Chang

Lee

et al. 2014

International Journal of Food Sciences and Nutrition

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C57BL/6J mice were divided into control group (C), CLA, c9t11, or t10c12 groups. CLA and t10c12 significantly increased α-tocopherol levels in the plasma and various tissues in experiment 1. The CLA and t10c12 groups also showed a significant increase in hepatic α-tocopherol transfer protein (α-TTP) levels. In experiment 2, mice were divided into control, CLA, R (rosiglitazone, a PPARγ agonist), or CLA+R groups. Vitamin E levels in the liver, epididymal fat pad, kidney, and plasma were increased by CLA, and this effect was reduced in the CLA+R group. t10,c12-CLA is the most active isomer in the CLA mixture in the regulation of tissue vitamin E status and α-TTP protein levels in mice. The increase in liver vitamin E status in CLA-fed mice is mainly due to the effect of PPARγ inhibition.

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Roles of enzymatic antioxidants in stress response and signaling in plants

Ghorbel,

Olayen,

Brini

2024

Defense-Related Proteins in Plants

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Elevation of tissue α-tocopherol levels by conjugated linoleic acid in C57BL/6J mice is not associated with changes in vitamin E absorption or α-carboxyethyl hydroxychroman production

Cited by 14 publications

References 60 publications

Tocopherols and tocotrienols in serum and liver of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation

Tocopherols and tocotrienols in serum and liver of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation

trans-10,cis-12 Conjugated linoleic acid specifically increases tissue α-tocopherol mediated by PPARγ inhibition in mice

Roles of enzymatic antioxidants in stress response and signaling in plants

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