Eleven Cases of Sarcoidosis of the Optic Nerve

Beardsley, Thomas L.; Brown, Steven V.L.; Sydnor, Charles F.; Grimson, Baird S.; Klintworth, Gordon K.

doi:10.1016/0002-9394(84)90447-1

Cited by 94 publications

(32 citation statements)

References 26 publications

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“…The optic nerve head granuloma was the first presentation of sarcoidosis in 23/34 of the cases (67.6%), although, when Histological examination of an involved optic nerve head from a case that required enucleation after the development of painful anterior uveitis and secondary glaucoma showed non-caseating granulomatous inflammation protruding forward through the scleral canal with an overlying retinal detachment. 17 In a further case following enucleation the optic nerve head anterior to the lamina cribrosa was oedematous with a large nodule of epithelioid cells and lymphocytes adjacent to the outer nuclear layer of the retina. A further nodule was present in the centre of the optic cup.…”

Section: Discussionmentioning

confidence: 96%

“…Poor recovery was associated primarily with additional ocular pathology such as uveitis,- 7,12,15,17,18 central retinal vein occlusion, 16 and retinal detachment, 18,25 with only one case of poor outcome directly due to the optic nerve head granuloma. 5 There was been one other report of the use of OCT to investigate optic nerve head granuloma.…”

Section: Discussionmentioning

confidence: 99%

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The Evolution of an Optic Nerve Head Granuloma Due to Sarcoidosis

Hickman

Quhill

Pepper

2016

Neuro-Ophthalmology

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Sarcoidosis can affect the optic nerves by means of optic disc oedema secondary to posterior uveitis, optic disc oedema secondary to raised intracranial pressure, optic neuritis, optic atrophy secondary to compression or infiltration from a primary central nervous system lesion, and primary granuloma of the optic nerve head. The authors report the use of optical coherence tomography in assessing the response to immunosuppression in a 57-year-old woman with an optic nerve head granuloma. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

The Evolution of an Optic Nerve Head Granuloma Due to Sarcoidosis

Hickman

Quhill

Pepper

2016

Neuro-Ophthalmology

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“…Review of the literature demonstrates that involvement of the ONH itself must indeed be an unusual occurrence [11][12][13][14][15]. Our case, rare, demonstrates that optic nerve sarcoi dosis may occur as the first sign of this systemic disease.…”

Section: Discussionmentioning

confidence: 74%

Optic Nerve Granuloma as First Sign of Systemic Sarcoidosis

et al. 1994

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We report a rare casse of optic nerve involvement as the first sign of systemic sarcoidosis. A 43-year-old white woman presented with visual loss in her right eye, and the clinical appearance of optic nerve head swelling. Visual acuity was reduced to 20/200, and the only clinical signs were the presence of an enlarged optic nerve head, with engorged retinal veins and flame-shaped haemorrhages. Computed tomography scans showed an enlarged orbital portion of the right optic nerve, which was confirmed by magnetic resonance imaging. With a diagnosis of optic nerve tumour (possibly glioma) a surgical resection of the tumour was performed. Histopathology showed multiple nodular granulomas with epithelioid cells, consisted with the diagnosis of sarcoidosis. This was confirmed by systemic involvement of the parotids and liver. We review the literature and consider all possible involvement of the optic nerve in sarcoidosis. The rarity of systemic sarcoidosis with a first manifestation as papilloedema is discussed.

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“…Residual high signal intensity in the optic nerve of the right eye may indicate toxic optic nerve damage caused by linezolid rather than the presence of glaucomatous optic atrophy. In the present case, we fi rst considered that the condition occurred because of bilateral retrobulbar optic neuritis caused by sarcoidosis, as Beardsley et al 16 and Shozushima et al 17 reported that sarcoidosis often invites retrobulbar optic neuritis. Some authors have also reported that a subTenon's capsule injection of triamcinolone acetonide is effective for optic neuritis.…”

Section: Discussionmentioning

confidence: 96%