Elimination of lymphatic filariasis: current perspectives on mass drug administration

Gyapong, John; Owusu, Irene Offei; Vroom, Frances Baaba da-Costa; Mensah, Ernest; Gyapong, Margaret

doi:10.2147/rrtm.s125204

Cited by 65 publications

(72 citation statements)

References 58 publications

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“…When discussing components of a successful community engagement strategy, we found that leveraging existing community structures such as chiefs and village elders to deliver messaging was vital, as it inferred legitimacy on the program and helped combat mistrust. This finding has been widely reported in previous studies that have highlighted the role of traditional and religious leaders in promoting trust [14,28,29]. In addition, and not previously discussed in the NTD literature, is the need for appropriate spacing for community engagement activities so as to give the messaging an opportunity to sufficiently circulate among community members.…”

Section: Plos Neglected Tropical Diseasessupporting

confidence: 68%

“…The negative impact that rumors and fears surrounding side-effects can have on uptake has been extensively reported in the literature and this study adds further evidence that many of these myths, such as fears of covert contraception or poisoning, are common across different program and country settings [14,21,29]. However, there has been less consideration of the drivers of these fears and how they can be addressed.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 70%

“…A conceptual framework mapping out the key components of community-wide MDA was developed as a tool to shape the codebook and coding process. Development of the framework was based on existing literature and authors' implementation experience regarding delivery of MDA programs [14][15][16][17]. The framework (Fig 1) presents key inputs and contextual factors relevant to the planning and delivery of MDA leading to two outputs: "reach" and "uptake".…”

Section: Data Management and Analysismentioning

confidence: 99%

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Implementer and recipient perspectives of community-wide mass drug administration for soil-transmitted helminths in Kwale County, Kenya

et al. 2020

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Soil-transmitted helminthiases (STH) are one of 17 neglected tropical diseases (NTDs) earmarked for control or elimination by 2020 in the WHO's Roadmap on NTDs. Deworming programs for STH have thus far been focused on treating preschool and school-aged children; however, there is a growing consensus that to achieve elimination of STH transmission, programs must also target adults, potentially through community-wide mass drug administration (MDA). There is currently a gap in the literature on what components are required to deliver community-wide MDA for STH in order to achieve high intervention reach and uptake. Nested within the TUMIKIA Project, a cluster randomized trial in Kenya evaluating the effectiveness of school-based deworming versus community-wide MDA, we collected qualitative data from program implementers and recipients in eight clusters where community-wide MDA was delivered. Data collection included semi-structured in-depth interviews (n = 72) and focus group discussions (n = 32). A conceptual framework for drug distribution was constructed to help build an analysis codebook. Case memos were developed for each top-level theme. Community-wide MDA for STH was perceived as a complex intervention with key administrative and social mobilization domains. Key actionable themes included: (1) developing an efficient strategy to allocate reasonable workload for implementers to cover all targeted households; (2) maximizing community drug distributors' motivation through promoting belief in the effectiveness of the intervention and providing sufficient financial incentives; (3) developing effective capacity building strategies for implementers; and (4) implementing a context-adapted community engagement strategy that leverages existing community structures and takes into consideration past community experiences of MDAs. Transitioning from STH control to elimination goals requires significant planning and action to ensure community-wide MDA is delivered with sufficient reach and uptake. We

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Section: Plos Neglected Tropical Diseasessupporting

confidence: 68%

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 70%

Section: Data Management and Analysismentioning

confidence: 99%

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Implementer and recipient perspectives of community-wide mass drug administration for soil-transmitted helminths in Kwale County, Kenya

et al. 2020

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“…Although this is certainly an underestimate of the overall impact of this disease in the USA, the global impact of lymphatic filariasis is far greater. Current estimates indicate that despite remarkable mass drug administration (MDA) programs, millions of people are currently infected with lymphatic filariasis, which is considered one of the leading global causes of disability (Gyapong et al, 2018). Furthermore, there are many areas of the world where MDA is not expected to eradicate this disease, so greater mosquito control efforts may be needed to accomplish this goal (Koudou et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Methods for the generation of heritable germline mutations in the disease vector Culex quinquefasciatus using clustered regularly interspaced short palindrome repeats‐associated protein 9

Liu

et al. 2019

Insect Molecular Biology

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Culex quinquefasciatus is a vector of many diseases that adversely impact human and animal health; however, compared to other mosquito vectors limited genome engineering technologies have been characterized for this vector. Clustered regularly interspaced short palindrome repeats‐associated protein 9 (CRISPR‐Cas9) based technologies are a powerful tool for genome engineering and functional genetics and consequently have transformed genetic studies in many organisms. Our objective was to improve upon the limited technologies available for genome editing in C. quinquefasciatus to create a reproducible and straightforward method for CRISPR‐Cas9‐targeted mutagenesis in this vector. Here we describe methods to achieve high embryo survival and mutagenesis rates and we provide details on the injection supplies and procedures, embryo handling and guide RNA (gRNA) target designs. Through these efforts, we achieved embryo survival rates and germline mutagenesis rates that greatly exceed previously reported rates in this vector. This work is also the first to characterize the white gene marker in this species, which is a valuable phenotypic marker for future transgenesis or mutagenesis of this vector. Overall, these tools provide the framework for future functional genetic studies in this important disease vector and may support the development of future gene drive and genetic technologies that can be used to control this vector.

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“…While this is certainly and underestimate of the overall impact of this disease in the US, the global impact of lymphatic filariasis is far greater. Current estimates indicate that despite remarkable mass drug administration (MDA) programs, millions of people are currently infected with lymphatic filariasis, which is considered to be one of the leading global causes of disability (Gyapong et al 2018). Furthermore, there are many areas of the world where MDA is not expected to eradicate this disease, but mosquito control could be the key to eliminating this disease (Koudou et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Methods for the generation of heritable germline mutations in the disease vector Culex quinquefasciatus using CRISPR/Cas9

Li¹,

Liu

et al. 2019

Preprint

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23Culex quinquefasciatus is vector of many diseases that adversely impact human and animal health; 24 however, compared to other mosquito vectors limited genome engineering technologies have been 25 characterized for this vector. CRISPR-Cas9 based technologies are a powerful tool for genome 26 engineering and functional genomics and consequently have transformed genomics studies in 27 many organisms. Our objective was to improve upon the limited technologies available for 28 genome editing in Cx. quinquefasciatus to create a reproducible and straightforward method for 29 CRISPR-Cas9-targeted mutagenesis in this vector. Here we describe methods to both improve 30 embryo survival rates as well as mutagenesis rates by optimizing injection supplies and equipment, 31 embryo injection procedures, embryo handling and gRNA target design. Through these efforts, 32 we achieved embryo survival rates and germline mutagenesis rates that greatly exceed any 33 previously reported rates in this vector. This work was also the first characterize the white gene 34 marker, which is a valuable phenotypic marker for future transgenesis or mutagenesis of this 35

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Elimination of lymphatic filariasis: current perspectives on mass drug administration

Cited by 65 publications

References 58 publications

Implementer and recipient perspectives of community-wide mass drug administration for soil-transmitted helminths in Kwale County, Kenya

Implementer and recipient perspectives of community-wide mass drug administration for soil-transmitted helminths in Kwale County, Kenya

Methods for the generation of heritable germline mutations in the disease vector Culex quinquefasciatus using clustered regularly interspaced short palindrome repeats‐associated protein 9

Methods for the generation of heritable germline mutations in the disease vector Culex quinquefasciatus using CRISPR/Cas9

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