Elimination of Mother-to-child Transmission of Syphilis: Challenge and Solution

Fan, Shang­rong; Wang, Ailing; Wang, Lınhong

doi:10.1097/fm9.0000000000000018

Cited by 5 publications

(8 citation statements)

References 62 publications

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“…It is necessary to establish an innovative working model that protects privacy and allows pregnant women and their sexual partners to receive standardized anti-syphilis treatment at the same time, thereby effectively reducing the positive rate of neonatal serological syphilis testing and the incidence of congenital syphilis. The key to the success of the program to prevent and control MTCT of syphilis lies in the early diagnosis, early treatment, and standardized follow-up of syphilis-positive pregnant women [ 24 ]. A region can rely on the sexually transmitted disease (STD) epidemic monitoring network to form a referral pattern centered on treatment and follow-up institutions, and at the same time use government actions to supervise and evaluate related work, fundamentally improving the quality of project operation.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Adverse Pregnancy Outcomes of Pregnant Women with Syphilis and Maternal-Infant Serological Association in Changzhou, China, 2015–2019

Bian

Qin

Zhang

et al. 2022

Stem Cells International

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Background. Although the prevention of mother-to-child transmission of syphilis program in China has achieved national coverage for 7 years, controversy still exists regarding the treatment of syphilis and the serological significance of syphilis. Objective. To explore the occurrence and influencing factors of adverse pregnancy outcomes among pregnant women with syphilis in Changzhou from 2015-2019 and to further analyze the impact of syphilis serologic titers on perinatal outcomes and neonatal serologic outcomes. Methods. Syphilis-infected pregnant women reported in Changzhou City from 2015 to 2019 were selected as the study population (data were obtained from the “China Information System for Prevention of Mother-to-child Transmission of AIDS, Syphilis and Hepatitis B.” Demographic characteristics, laboratory tests, and medication were collected to describe adverse pregnancy outcomes and the distribution of non-pale leptospiral antibody titers during pregnancy. Multivariate logistic regression was used to analyze the factors influencing adverse pregnancy outcomes. We also compared differences in syphilis titers among mothers who received different interventions, differences in serologic outcomes of their children, and correlations between them. Results. For mothers with syphilis infection, we found no treatment during pregnancy (OR =1.70) and an initial titer greater than 1 : 8 (OR =2.28) to be risk factors. For treated pregnant women, increasing age (OR =1.08), lack of standardized treatment (OR =1.87), and initial titer greater than 1 : 8 (OR =1.69) were risk factors, while previous parity was a protective factor (OR =0.62). For untreated pregnant women, marital status (OR =2.40) and initial titers greater than 1 : 8 (OR =3.57) were risk factors. There were statistically significant differences ( P < 0.01 ) in serologic titer changes, time to antibody regression, and time to exclusion of syphilis infection in children of pregnant women with syphilis infection after receiving different interventions during pregnancy, but different time distributions of interventions had no effect on these three indicators. Conclusion. Pregnant women with syphilis should actively cooperate with their doctors in the standardized treatment of pregnancy, and doctors should also pay more attention to pregnant women with syphilis whose initial titers are greater than 1 : 8. High-quality prenatal care is a key component in interrupting mother-to-child transmission of syphilis and preventing various adverse pregnancy outcomes. The adaptation of standardized treatment protocols for pregnant women with syphilis in China is a strong proof of the progress of precision medicine.

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Section: Discussionmentioning

confidence: 99%

Analysis of Adverse Pregnancy Outcomes of Pregnant Women with Syphilis and Maternal-Infant Serological Association in Changzhou, China, 2015–2019

Bian

Qin

Zhang

et al. 2022

Stem Cells International

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“…The rate of congenital syphilis also increased, from 8.4 cases per 100 000 live births to 15.7 cases per 100 000 live births. 2 3 …”

Section: Discussionmentioning

confidence: 99%

Intra-urban differentials of congenital and acquired syphilis and syphilis in pregnant women in an urban area in northeastern Brazil

Souza

Teixeira²,

Santana³

et al. 2021

Transactions of the Royal Society of Tropical Medicine and Hygiene

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Background Currently syphilis is considered an epidemic disease worldwide. The objective of this study was to identify intra-urban differentials in the occurrence of congenital and acquired syphilis and syphilis in pregnant women in the city of Natal, in northeast Brazil. Methods Cases of syphilis recorded by the municipal surveillance system from 1 January 2011 to 30 December 2018 were analysed. Spatial statistical analyses were performed using the kernel density estimator of the quadratic smoothing function (weighted). SaTScan software was applied for the calculation of risk based on a discrete Poisson model. Results There were 2163 cases of acquired syphilis, 738 cases of syphilis in pregnant women and 1279 cases of congenital syphilis. Kernel density maps showed that the occurrence of cases is more prevalent in peripheral areas and in areas with more precarious urban infrastructure. In 2011–2014 and 2015–2018, seven statistically significant clusters of acquired syphilis were identified. From 2011 to 2014, the most likely cluster had a relative risk of 3.54 (log likelihood ratio [LLR] 38 895; p<0.001) and from 2015 to 2018 the relative risk was 0.54 (LLR 69 955; p<0.001). Conclusions In the municipality of Natal, there was a clustered pattern of spatial distribution of syphilis, with some areas presenting greater risk for the occurrence of new cases.

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“…Dukungan sosial bagi ibu hamil dapat bersumber dari pasangan. Suami tidak secara langsung mempengaruhi pemanfaatan pelayanan kesehatan, tetapi sebagai faktor motivasi untuk membangkitkan niat dalam memanfaatkan pelayanan kesehatan (Fan et al, 2019) 58…”

Section: Hubunganunclassified

Analisis faktor keikutsertaan screening hepatitis “B” pada ibu hamil

Apriadi

2022

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Background: Nagan Raya Regency is included in the top 5 districts/cities with the fourth highest number of hepatitis in Aceh Province. The hepatitis B screening program has not been implemented properly. The impact of the low coverage of this program affects public ignorance about the spread of hepatitis B from sufferers to other communities.Objective: This study aims to analyze the participation factors for Hepatitis B screening in pregnant women in the working area of the Ujong Patihah Health Center.Method: This research design is cross sectional study, in 2021. Data were collected using a questionnaire with a sample size of 220 pregnant women. Data collection was carried out by direct interviews with respondents, using a questionnaire instrument. Data analysis used the Cgi-square statistical test with a significance level of 95%, and continued with multivariate analysis using the Binary Logistics Regression test.Results: Bivariate analysis showed that there was a relationship between knowledge (p= 0.022), mother's attitude (p= 0.010), husband's role (p = 0.018), role of health workers (p = 0.028) and participation in hepatitis B screening, while education did not affect participation in hepatitis B screening (p= 0.668). Multivariate results showed that the mother's attitude was the dominant factor for participation in hepatitis B screening (OR= 2.24).Conclusion: Positive attitudes had a 2.24 times relationship to the participation of pregnant women in hepatitis B screening than negative attitudes.

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Elimination of Mother-to-child Transmission of Syphilis: Challenge and Solution

Cited by 5 publications

References 62 publications

Analysis of Adverse Pregnancy Outcomes of Pregnant Women with Syphilis and Maternal-Infant Serological Association in Changzhou, China, 2015–2019

Analysis of Adverse Pregnancy Outcomes of Pregnant Women with Syphilis and Maternal-Infant Serological Association in Changzhou, China, 2015–2019

Intra-urban differentials of congenital and acquired syphilis and syphilis in pregnant women in an urban area in northeastern Brazil

Analisis faktor keikutsertaan screening hepatitis “B” pada ibu hamil

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