2022
DOI: 10.1016/j.lfs.2022.120751
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Ellagic acid ameliorates high fructose-induced hyperuricemia and non-alcoholic fatty liver in Wistar rats: Focusing on the role of C1q/tumor necrosis factor-related protein-3 and ATP citrate lyase

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Cited by 15 publications
(5 citation statements)
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“…This study also demonstrated that the administration of defatted walnut power extract improved the gut microbiota diversity disrupted by NAFLD [195]. A more recent study demonstrated that EA ameliorates high fructose-induced hyperuricemia and NAFLD through activation of C1q/tumour necrosis factor-related protein (CTRP3) and inhibition of ATP citrate lyase (ACL) in male albino rats [196]. Hyperuricemia occurs due to the damaged metabolism of uric acid [197] and is attributed as a risk factor for NAFLD [198][199][200].…”
Section: Therapeutic Efficacymentioning
confidence: 73%
“…This study also demonstrated that the administration of defatted walnut power extract improved the gut microbiota diversity disrupted by NAFLD [195]. A more recent study demonstrated that EA ameliorates high fructose-induced hyperuricemia and NAFLD through activation of C1q/tumour necrosis factor-related protein (CTRP3) and inhibition of ATP citrate lyase (ACL) in male albino rats [196]. Hyperuricemia occurs due to the damaged metabolism of uric acid [197] and is attributed as a risk factor for NAFLD [198][199][200].…”
Section: Therapeutic Efficacymentioning
confidence: 73%
“…It also mitigates glucose-induced damage to pancreatic mesangial cells by activating the PI3K/Akt/FOXO3 signaling pathway, restoring pancreatic cell function, and reducing serum glucose concentration [ 20 ]. EA improves insulin resistance in hyperuricemic rats by activating C1q/tumor necrosis factor-associated protein-3 and inhibiting ATP citrate lyase, thereby increasing glucose metabolism [ 55 ]. EA reduces serum glucose levels by decreasing advanced glycation end products and increasing glucose utilization [ 56 ].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, an initial evaluation of ferulic acid's anticancer activity in HepG2 cells demonstrated its role in inhibiting tumor cell proliferation through inducing apoptosis and autophagy . High-fructose-induced hyperuricemia and NAFLD C1q /CTRP3(+)/ACL(-) (Elseweidy et al, 2022) Ferulic acid Cecal ligation and perforation (CLP)-induced and lipopolysaccharide (LPS)-induced ALI GSK-3β/CREB/ NF-κB(-) (Cao et al, 2021) Aflatoxin B1-induced liver damage CYP450(-)/Nrf2/GST(+) (Wang, He, et al, 2021) CCl4-induced hepatic fibrosis TGF-β1/ Smads(-) (Mu et al, 2018) HCHF-induced NASH ROCK/NF-κB(-) (Wei et al, 2021) HFD-induced NAFLD PPARα(+) (Luo et al, 2022) Chlorogenic acid CCl4-induced liver fibrosis and inflammation TLR4/MyD88/NF-κB(-) (Shi et al, 2013) ANIT-induced liver injury STAT3/NF-κB(-) (Tan et al, 2016) CCl4-induced liver injury NLRP3(-)/Nrf2(+) (Shi et al, 2018) HFD-induced NAFLD TLR4(-) (Shi et al, 2021) MCDD diet-induced NAFLD LPS-TLR4-MyD88(-) (Gu et al, 2023) MCD diet-induced NAFLD ECM/HSCs(-) (Miao et al, 2022) HCC cells Hep-G2 and Huh-7 NF-κB(-)/BBC3(+) (Jiang et al, 2021) Gallic acid aHSCs TRADD/RIP3(+) (Chang et al, 2015) HFD-induced NAFLD rats and palmitic acid (PA) and oleic acid (OA)-treated hepatocytes AMPK/ACC/PPARα(-) (J. Fructose-induced NAFLD AMPK/SREBP-1/ ACC/ FASN axis (-) (Lu et al, 2023)…”
Section: Ferulic Acidmentioning
confidence: 99%
“…Another study suggested that ellagic acid treatment protected against NAFLD by modulating lipid metabolism through the activation of AMPK signaling (ALTamimi et al, 2022). Furthermore, a recent study showed that ellagic acid can alleviate high‐fructose intake diet‐induced hyperuricemia in rats with NAFLD by activating C1q/tumor necrosis factor‐related protein‐3 (CTRP3) and inhibiting ATP citrate lyase (ACL) (Elseweidy et al, 2022). While the effects of ellagic acid on HCC, such as antiangiogenesis, anti‐inflammatory, and antiproliferative actions, have been observed, there is still a need to explore new signaling pathways (Aishwarya et al, 2021).…”
Section: Mechanisms Of Polyphenolic Compounds Protect Against Hepatic...mentioning
confidence: 99%