EHV-1 infection is responsible for huge economic losses in equines due to abortion and neonatal mortality. In this study, we describe 4 cases of abortion and neonatal deaths from pregnant mares and a she-donkey from different localities in Egypt during the period from May 2015 to October 2017. Attempts were made to isolate and identify EHV-1, in addition to compare the different pathological lesions in various tissues of the necropsied cases. EHV-1 was successfully isolated from two aborted fetuses and one dead neonatal foal from mares, beside one aborted fetus from a she-donkey. The positive cases showed cytopathic effect on embryonated chicken eggs scattered on chorioallantoic membrane. Moreover, PCR was applied for the pock lesions and revealed positive results for EHV-1. Interstitial pneumonia, bronchopneumonia and necrosis of hepatic, myocardial, microcotyledonary tissues besides disseminated thrombi were the main encountered lesions. Intranuclear inclusion bodies were demonstrated in brain, liver, placenta and pulmonary tissues. Here, we describe EHV-1 induced brain lesions represented by degenerated neurons, vascular endotheliosis with intranuclear inclusion bodies in the aborted she-donkey fetus. Lesions were more sever in the aborted fetuses from mares than the one from the she-donkey. EHV-1 antigen was detected by immunohistochemistry staining.

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E quine neoplasia leads to economic losses which ranged from undesirable effects on the animal's skin to locomotors and reproductive dysfunctions. Equine sarcoid is considered to be one of the most prevalent skin affections in equids (Chambers et al., 2003). It represents nearly 20% of equine tumors and about 90% of equine skin neoplasia. Although it had a low mortality rate, it has a direct effect on the material value of horses and may lead to lameness according to their locations (Goodrich et al., 1998). (Valentine, 2006) recorded the most common neoplasms in equine populations as the following; sarcoid (51.4%), squamous cell carcinoma (SCC) (18.3%) beside melanocytic tumors, papillomas, and mast cell tumors were, constituting (17.8%). while, lymphoma, fibrosarcoma, fibroma, schwannoma, hemangiosarcoma, lipoma, malignant mela-