Ellagic Acid Antiinflammatory and Antiapoptotic Potential Mediate Renoprotection in Cisplatin Nephrotoxic Rats

Abstract

Ellagic acid (EA) renoprotective effect against cisplatin (CIS)-induced nephrotoxicity remains elusive. Therefore, male Sprague-Dawley rats received CIS alone or EA (10 and 30 mg/kg, p.o.) for 5 days before and after CIS injection. CIS increased serum levels of blood urea nitrogen, creatinine, γ-glutamyl transferase, and reduced those of albumin and total protein. It also raised serum endothelin-1, as well as serum and renal nitric oxide, tumor necrosis factor-α, and monocyte chemoattractant protein-1. CIS enhanced the renal caspase-3, hemeoxygenase (HO)-1, nuclear factor-κB, and inducible nitric oxide. EA hampered CIS-induced nephrotoxicity manifested by an enhancement of the glomerular filtration rate which was associated by the reduction of inflammatory mediators and the apoptotic marker in the serum and/or kidney. The present study discloses that EA suppresses HO-1 and, its renoprotection is also linked to its anti-inflammatory and antiapoptotic properties, as well as the reduction of nitric oxide and endothelin-1.

Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy

“…Inflammation was shown to be increased in a study conducted on rats where nephrotoxicity was created by cisplatin (El-Garhy et al, 2014). In all cases in which inflammatory response is effective, pro-inflammatory cytokines, particularly TNF-α and IL-1β, are released Yayla et al, 2014).…”

Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin‐induced neurotoxicity in rats

“…Concomitant administration of EA with DOX reduced brain MDA, TNF‐α, and Casp‐3 confirming the studies in Refs. . In contrast, EA raise GSH and improve histopatological examinations.…”

Combination of carvacrol with simvastatin improves the lipid‐lowering efficacy and alleviates simvastatin side effects

“…After another wash with PBS, the antibody–biotin–avidin–peroxidase complex was developed using diaminobenzidine tetrahydrochloride (DAB Substrate Kit; Vector Laboratories Inc.). Sections were counterstained with hematoxylin, dehydrated, and cleared in xylene then cover slipped, where the reaction appeared as a brown cytoplasmic reaction …”