Ellagic acid, pomegranate and prostate cancer — a mini review

Bell, Carolyn L.; Hawthorne, Susan

doi:10.1211/jpp.60.2.0001

Cited by 140 publications

(79 citation statements)

References 47 publications

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“…The increased content of punicalagins and ellagic acid derivatives is especially interesting since the health benefit of the pomegranate fruit was largely attributed to these two types of phenolics (Seeram et al, 2004(Seeram et al, , 2005aBell and Hawthorne, 2008). Punicalagin is the most potent antioxidant among the pomegranate phenolics (Gil et al, 2000;Fischer et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…The pomegranate (Punica granatum L.) has gained high economic value in recent years due to the large volume of in vivo and in vitro studies attributing numerous health benefits to the fruit and its products (extensively reviewed in Seeram et al, 2006;Bell and Hawthorne, 2008;de Nigris et al, 2007;Davidson et al, 2009). Consequently, pomegranate production has expanded to new regions where the available water is of poor quality, including recycled or saline water .…”

Section: Introductionmentioning

confidence: 99%

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Salinity effects on colour and health traits in the pomegranate (Punica granatum L.) fruit peel

Borochov‐Neori

Judeinstein

Tripler

et al. 2014

IJPTI

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Irrigation water salinity effects on colour and health ingredients in the pomegranate peel were studied in two accessions, 'Wonderful' and 'SP-2', grown under a wide range of salinities, 1.2 to 9 dS m -1 . Ripe fruit peels were analysed for phenolics and anthocyanins composition, and antioxidative capacity. Total phenolics concentration and antioxidative capacity were determined by the Folin-Ciocalteau and FRAP assays, respectively. Phenolics and anthocyanins composition was analysed by RP-HPLC. Increased salinity enhanced considerably the overall accumulation of phenolics and anthocyanins, and the antioxidative capacity in both cultivars; the magnitude of the effects was accession dependent. Mono-and di-glucosides of cyanidins, pelargonidins, and delphinidines were detected at proportions that varied with accession and salinity. Increased concentrations of gallotannins, flavonols and ellagic acid derivatives in 'Wonderful', and punicalagins, flavonols and ellagic acid derivatives in 'SP-2' accompanied elevated salinity levels. The results may benefit the pomegranate juice and byproduct valourisation industries, especially in the face of global water quality deterioration. Salinity effects on colour and health traits in the pomegranate 55Keywords: anthocyanins; antioxidative capacity; cyanidin; delphinidin; ellagic acid; health value; lysimeters; pelargonidin; phenolics; pomegranate; Punica granatum L.; punicalagin; salinity; preharvest; postharvest.Reference to this paper should be made as follows: Borochov-Neori, H., Judeinstein, S., Tripler, E., Holland, D. and Lazarovitch, N. (2014)

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Salinity effects on colour and health traits in the pomegranate (Punica granatum L.) fruit peel

Borochov‐Neori

Judeinstein

Tripler

et al. 2014

IJPTI

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“…It has anticarcinogenic, antioxidant and antifibrosis properties (Mukhtar et al, 1988;Thresiamma and Kuttan, 1996;Stoner and Gupta, 2001;Han et al, 2006). The anticarcinogenic effect of EA was shown in several cancer types including esophageal, colon, skin, breast and prostate cancers (Stoner and Gupta, 2001;Larrosa et al, 2006;Bell and Hawthorne, 2008;Strati et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Ellagic Acid Inhibits Migration and Invasion by Prostate Cancer Cell Lines

Pitchakarn¹,

Chewonarin²,

Ogawa³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Polyphenolic compounds from pomegranate fruit extracts (PFEs) have been reported to possess antiproliferative, pro-apoptotic, anti-inflammatory and anti-invasion effects in prostate and other cancers. However, the mechanisms responsible for the inhibition of cancer invasion remain to be clarified. In the present study, we investigated anti-invasive effects of ellagic acid (EA) in androgen-independent human (PC-3) and rat (PLS10) prostate cancer cell lines in vitro. The results indicated that non-toxic concentrations of EA significantly inhibited the motility and invasion of cells examined in migration and invasion assays. The EA treatment slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 from both cell lines. We further found that EA significantly reduced proteolytic activity of collagenase/gelatinase secreted from the PLS-10 cell line. Collagenase IV activity was also concentration-dependently inhibited by EA. These results demonstrated that EA has an ability to inhibit invasive potential of prostate cancer cells through action on protease activity.

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“…Over the last few years, a number of in vivo and in vitro studies have provided evidence of important pharmacological properties including antioxidant, anti-inflammatory [7,8,9,10,11] and anticarcinogenic activities [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Rosillo

Sánchéz-Hidalgo

Cárdeno

et al. 2011

Biochemical Pharmacology

153

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 37A c c e p t e d M a n u s c r i p t

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Ellagic acid, pomegranate and prostate cancer — a mini review

Cited by 140 publications

References 47 publications

Salinity effects on colour and health traits in the pomegranate (Punica granatum L.) fruit peel

Salinity effects on colour and health traits in the pomegranate (Punica granatum L.) fruit peel

Ellagic Acid Inhibits Migration and Invasion by Prostate Cancer Cell Lines

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

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