Elucidating the Role of Interleukin 1β and Prostaglandin E2 in Upper Airway Mucosal Wound Healing

Sandulache, Vlad C.; Chafin, J. Brett; Li-Korotky, Ha-Sheng; Otteson, Todd D.; Dohar, Joseph E.; Hebda, Patricia A.

doi:10.1001/archotol.133.4.365

Cited by 25 publications

(40 citation statements)

References 33 publications

(59 reference statements)

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“…Vehicle-treated control animals showed a bimodal pattern of PGE-2 subglottic secretory levels over time, consistent with our previous studies 5,7 and reflecting the involvement of PGE-2 in the acute inflammatory and the tissue remodeling phases of wound healing. The correlation between PGE-2 level in the secretions and corresponding mucosal thickness at PO day 56 supports the relevance of PGE2 as a marker for degree of stenosis (Figure 8).…”

Section: Discussionsupporting

confidence: 91%

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Cyclooxygenase-2 Inhibition for the Prevention of Subglottic Stenosis

Çetin

Tobey²,

Sandulache³

et al. 2012

Arch Otolaryngol Head Neck Surg

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Section: Discussionsupporting

confidence: 91%

“…5,7 In other tissue types, modulation of inflammation has been linked to decreased scarring and fibrosis. 17 Although some degree of inflammation is necessary for reparative post-natal skin wound healing, regenerative “scarless” fetal skin wound healing ensues in the absence of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Cyclooxygenase-2 Inhibition for the Prevention of Subglottic Stenosis

Çetin

Tobey²,

Sandulache³

et al. 2012

Arch Otolaryngol Head Neck Surg

Self Cite

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“…Additionally, the increase of IL-1β resulting from the accumulation of macrophages in the burn wound is another mechanism. The production of IL-1β within the wound bed stimulates the secretion of secondary inflammatory cytokines such as IL-6, IL-8 and PGE 2 [30]. …”

Section: Resultsmentioning

confidence: 99%

Skin Wound Healing and Phytomedicine: A Review

Pazyar

Yaghoobi²,

Rafiee³

et al. 2014

Skin Pharmacol Physiol

207

137

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Skin integrity is restored by a physiological process aimed at repairing the damaged tissues. The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling. Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing. These include Aloe vera, mimosa, grape vine, Echinacea, chamomile, ginseng, green tea, jojoba, tea tree oil, rosemary, lemon, soybean, comfrey, papaya, oat, garlic, ginkgo, olive oil and ocimum. Phytotherapy may open new avenues for therapeutic intervention on cutaneous wounds. This article provides a review of the common beneficial medicinal plants in the management of skin wounds with an attempt to explain their mechanisms.

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“…Markers of acute inflammation have been thoroughly described in the wound-healing literature, with particular emphasis on cytokines such as interleukin (IL)-1B, transforming growth factor (TGF)-β, and prostaglandin E2 (PGE2). [10][11][12] Previous studies have shown that the development of SGS is accompanied by an acute and robust inflammatory component, which likely triggers a shift in the cellular and molecular components of the healing wound in favor of profibrotic forces. 13 However, whether this initial inflammatory component is induced by local and innate immune mediators within the injured donor tissue or by circulating systemic cellular mediators within the recipient mouse remains to be seen.…”

mentioning

confidence: 99%