Elucidation of anti-HIV mechanism of sulfated cellobiose–polylysine dendrimers

Weiyue, Song; Li, Ying; Kanamoto, Taisei; Asai, Daisuke; Takemura, Hiromu; Nakashima, Hideki; Miyazaki, Kensuke; Yoshida, Takashi

doi:10.1016/j.carres.2020.108084

Cited by 4 publications

(5 citation statements)

References 22 publications

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“…The highest generation of PLLD could reach five thus far (Mehta et al, 2018), and by connecting polyethylene glycol (PEG) to the exterior of fourth generation PLLD, a fifth pseudogeneration PEGylated PLLD could be synthesized (Haque et al, 2017). Unlike polyetherimide, which could form an intact symmetry structure then be totally modified (Walsh et al, 2018(Walsh et al, , 2019, increased defects in the structure of PLLDs could be found with the increase in generation (Weiyue et al, 2020). The existence of these defects may be derived from the steric hindrance or the different lengths of the α-and ε-amino branches formed on the PLLD backbone that hides some of the amino functional groups inside without participating in the next steps of polymerization.…”

Section: Structure and Synthesismentioning

confidence: 99%

“…Several factors may affect the performance of LBD, including generation, size, topology, and modification strategies. As the generations increase, LBD could improve the retention time and loading effects (Li et al, 2016; but may also result in increased cytotoxicity and decreased antiviral effect (Weiyue et al, 2020). They found that the size of polylysine dendrigraft with the same molecular weight and density depends on its side chain topology.…”

Section: Structure and Synthesismentioning

confidence: 99%

“…Meanwhile, LBD could show a FIGURE 4 | (A) Chemical structure of G3KL (Siriwardena et al, 2018a); (B) Snapshot of G4 polylysine dendrimer in molecular dynamic simulation (Francoia et al, 2017). more potent antihuman immunodeficiency virus activity at the moderate molecular distance when modified by cellobiose with sulfated treatment to its second generation (Weiyue et al, 2020), thus proving its potential to be used as an antiviral agent.…”

Section: Antimicrobial Antifungal and Antiviral Agentsmentioning

confidence: 99%

“…Therefore, to improve its ability as high efficiency with low toxicity, medical safety index was used by dividing the minimum inhibition concentration by half hemolytic concentration in some cases (Grimsey et al, 2020). Modifications are needed to neutralize some of the cationic branches and disperse the concentrated positive charges, including lengthening the branches (Gan et al, 2019) and partial conjugation with polysaccharide (Weiyue et al, 2020).…”

Section: Antimicrobial Antifungal and Antiviral Agentsmentioning

confidence: 99%

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Recent Advances in Epsilon-Poly-L-Lysine and L-Lysine-Based Dendrimer Synthesis, Modification, and Biomedical Applications

Chen

Huang

et al. 2021

Front. Chem.

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With the advantages in biocompatibility, antimicrobial ability, and comparative facile synthesis technology, poly-L-lysine (PLL) has received considerable attention in recent years. Different arrangement forms and structures of the backbone endow lysine-based polymers with versatile applications, especially for ε-poly-L-lysine (EPL) and lysine-based dendrimer (LBD) compounds. This review summarized the advanced development of the synthesis and modification strategies of EPL and LBD, focus on the modification of bio-synthesis and artificial synthesis, respectively. Meanwhile, biomedical fields, where EPL and LBD are mainly utilized, such as agents, adjuvants, or carriers to anti-pathogen or used in tumor or gene therapies, are also introduced. With the deeper of knowledge of pharmacodynamics and pharmacokinetics of the drug system, the design and synthesis of these drugs can be further optimized. Furthermore, the performances of combination with other advanced methodologies and technologies demonstrated that challenges, such as scale production and high expenses, will not hinder the prospective future of lysine-based polymers.

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Section: Structure and Synthesismentioning

confidence: 99%

Section: Structure and Synthesismentioning

confidence: 99%

Section: Antimicrobial Antifungal and Antiviral Agentsmentioning

confidence: 99%

Section: Antimicrobial Antifungal and Antiviral Agentsmentioning

confidence: 99%

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Recent Advances in Epsilon-Poly-L-Lysine and L-Lysine-Based Dendrimer Synthesis, Modification, and Biomedical Applications

Chen

Huang

et al. 2021

Front. Chem.

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“…Combining both amine and sulphate moieties, sulphated cellobiose-polylysine dendrimers were studied by Yoshida et al [138]. They found that a shorter distance between the terminal sulphate cellobiose units increases the Anti-HIV-1 effect.…”

Section: Structurementioning

confidence: 99%

Polymers in the Medical Antiviral Front-Line

2020

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Antiviral polymers are part of a major campaign led by the scientific community in recent years. Facing this most demanding of campaigns, two main approaches have been undertaken by scientists. First, the classic approach involves the development of relatively small molecules having antiviral properties to serve as drugs. The other approach involves searching for polymers with antiviral properties to be used as prescription medications or viral spread prevention measures. This second approach took two distinct directions. The first, using polymers as antiviral drug-delivery systems, taking advantage of their biodegradable properties. The second, using polymers with antiviral properties for on-contact virus elimination, which will be the focus of this review. Anti-viral polymers are obtained by either the addition of small antiviral molecules (such as metal ions) to obtain ion-containing polymers with antiviral properties or the use of polymers composed of an organic backbone and electrically charged moieties like polyanions, such as carboxylate containing polymers, or polycations such as quaternary ammonium containing polymers. Other approaches include moieties hybridized by sulphates, carboxylic acids, or amines and/or combining repeating units with a similar chemical structure to common antiviral drugs. Furthermore, elevated temperatures appear to increase the anti-viral effect of ions and other functional moieties.

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