Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver

Synthetic Approaches to the 2019–2020 New Agrochemicals

“…Consequently, the health risk assessment of epyrifenacil (10) was evaluated in different studies, with the conclusion that the hepatotoxicity which this active ingredient causes in mice will not occur in humans. [28][29][30][31][32][33][34] 11 Saflufenacil The synthesis of epyrifenacil ( 10) is obtained from 2-chloro-4fluorophenol (12) using inexpensive reagents with which both heterocyclic rings are built in de novo syntheses. First 12 is converted with 2-chloro-3-oxobutanamide to the primary amide 13, which is cyclized with 1,1,3,3-tetramethoxypropane to the pyridone derivative 14.…”

“…Consequently, the health risk assessment of epyrifenacil ( 10 ) was evaluated in different studies, with the conclusion that the hepatotoxicity that this active ingredient causes in mice will not occur in humans. 28 29 30 31 32 33 34…”