Background: During the outbreak of COVID-19 in developing countries such as Iran, the management of healthcare waste has become a very important issue. It is necessary to investigate the risk of virus transmission through direct contact, inhalation, and environmental pollution to reduce transmission risk. The Hazard Analysis of Critical Control Points framework is used to simplify quick responses of waste management for facing the novel infectious disease. Objectives: The aim of this study was to use risk analysis frameworks to describe hazard critical control points (HACCP) and make recommendations and corrective actions for staff who work in healthcare facilities and communities experiencing the COVID-19 outbreak. Methods: In the present descriptive-analytical study, a team of environmental health experts identified the critical control points of healthcare waste produced in Razi Hospital and divided them into three categories and six steps. A tested and verified hazard analysis flow diagram was prepared to determine critical points in different steps of healthcare waste management. Critical control points were identified and analyzed by the team at each step. Recommendations and corrective actions were made for each control point. Results: The production rate significantly increased from 580 to 1,733 kg per day, probably caused by the increased use of disposable waste during the pandemic. Transportation, disinfection, and storage appeared to be associated with an individually high level of transmission risk of COVID-19 virus. Also, direct contact with infectious waste was often associated with a high risk of virus transmission. In the final disposal of healthcare waste, people were exposed to a lower level of risk. Conclusions: Training staff in different wards of the hospital to use proper personal protective equipment (PPE), hand washing, disinfectants, and ventilation could reduce the risk of COVID-19 transmission through healthcare waste. Using the HACCP method for providing recommendations and corrective actions could simplify responses to reduce the transmission risk of COVID-19 during pandemics.