Not least in view of the past decade, crises in the European Union (EU) have attracted much scholarly attention. At the same time, difficult decision-making situations and turning points have always been parts of the European integration process. Moreover, as founding and the two largest member states, France and Germany have been key drivers in the development of today’s EU polity. Strikingly, a systematic analysis of major crises covering the entire integration process and the comparative role that France–Germany have played, so far is lacking. Scholars tend to focus on instances of ‘successful’ crisis resolution or, more recently, on a presumably hegemonic Germany. This article, by contrast, argues and demonstrates why and how France and Germany, together, have been essential for the management and resolution of European-level political controversies and deadlock. To do so, the article considers nine major integration crises. It highlights different ways and means of bilateral leadership and their resulting impact on European integration. Case selection includes both successful crisis management and instances of failed or absent leadership.