Embelin as a Potential Drug Molecule: A Review

Kumar, Sakesh; Deshmukh, Rahul

doi:10.4172/2472-0992.1000144

Cited by 7 publications

(4 citation statements)

References 56 publications

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“…Furthermore, embelin has shown protective effects against acetic acid-induced ulcerative colitis in rats. Importantly, it exhibits a high safety margin, with an LD50 of up to 2000 mg/kg body weight in rats and mice, indicating a wide therapeutic index [6,7]. Berberine is another naturally occurring compound known to possess extremely promising biological and pharmacological activities [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Combination of Some Phytoconstituents of Pharmacological Interest on Cutaneous Wound Healing in Diabetic Rats

Deshmukh,

Sanghais,

Kate

et al. 2023

Middle East Res J Med Sci

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Persistent non-healing wounds present a substantial challenge in the context of diabetes management. This research delves into exploring the wound healing capabilities of a combination of natural plant-derived compounds, namely embelin, berberine, ferulic acid, and asiatic acid, in streptozotocin induced diabetic rats. Various wound models, including dead space, incision, and excision models, were employed to evaluate their impact. The phytoconstituents were carefully blended into an ointment formulation, with a concentration of 5% (w/w), specifically designed to cater to their individual strengths. Notably, diabetic rats exhibited a significant enhancement in wound closure and improved skin epithelialization. Furthermore, this combination of phytoconstituents exhibited efficacy when administered orally in both the incision and dead space wound models. In the incision wound model, granulation tissues were examined on the 8th day following the initial injury, and assessments were made for hydroxyproline, hexosamine, total protein. In streptozotocin-induced diabetic rats, both topical and oral applications of this combination revealed a marked increase in hydroxyproline, hexosamine, indicating a favorable impact on wound healing. Additionally, the combination led to a substantial improvement in wound breaking strength. When assessed in the dead space model, the combination notably increased the weight and breaking strength of granuloma tissue. These findings collectively point to the wound healing acceleration attributed to Combination in diabetic rats.

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Section: Introductionmentioning

confidence: 99%

Effect of Combination of Some Phytoconstituents of Pharmacological Interest on Cutaneous Wound Healing in Diabetic Rats

Deshmukh,

Sanghais,

Kate

et al. 2023

Middle East Res J Med Sci

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“…ribes are a major constituent of the ayurvedic formulation vidanga choorna. Emb exerts compelling antitumor activity against a plethora of cancer types via inhibiting multiple pathways …”

Section: Introductionmentioning

confidence: 99%

“…Emb exerts compelling antitumor activity against a plethora of cancer types via inhibiting multiple pathways. 9 Conventional chemotherapeutic drugs and most of the small-molecular anticancer agents cause consequential damages in terms of severe side effects to the surrounding healthy tissues and suffers from limitations like poor bioavailability, quick renal/blood clearance, enhanced multi-drug resistance, low accumulation in tumors, and so forth. To tackle these issues, different approaches were devised including the development of drug-delivery systems, gene therapy, combination therapy, targeted therapy, and many more.…”

Section: ■ Introductionmentioning

confidence: 99%

Targeted Delivery Polymeric Nanosystem Reinforced by Synergism of Embilin and RPI-1 for Therapeutics of Pancreatic Cancer

Arya

Joseph

Murali

et al. 2022

ACS Appl. Nano Mater.

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Pancreatic cancer (PC) is an aggressive form of malignancy with poor prognosis and feeble survival benefits. Here, we have ventured a personalized nanoconstruct constituted of the synergistic therapeutic benefit of two agents, namely, embelin and RPI-1, coloaded in a biodegradable nanodelivery system which has been tethered with a targeting peptide substrate for plectin-1, a surface biomarker of PC. The phytomolecule embelin, an alkylsubstituted hydroxyl benzoquinone isolated from the seeds of Embelia ribes, is introduced in this combination therapy and is known as a natural inhibitor of X-linked inhibitor of apoptosis protein and executes anticancer activity via the NF-kB pathway. On the other hand, tyrosine-protein kinase Met (c-MET) is a biomarker of PC wherein the molecule RPI-1, an indolinone derivative, is selective to the c-MET inhibitor. After conducting a series of systematic cytotoxicity evaluations followed by enumeration of combination index, a standalone synergic ratio of embelin and RPI-1 (1: 4.7) was evolved that executed a benchmarked PC-selective toxicity profile. This composition was precisely incorporated within a PC-targeted PLGA−chitosan core− shell nanoparticle delivery system for avoiding collateral damages. Appealing features of the nanoconstruct including biocompatibility, PC-targeted uptake, and subsequent execution of cytotoxicity and antimetastatic properties have been systematically evaluated on the PC cell line PANC-1 and later on the xenograft PC model of zebra fish. Finally, the unique metabolic changes associated with the therapeutic action of embelin and RPI-1 was scrutinized by surface-enhanced Raman spectroscopy and liquid chromatography−mass spectrometry analysis wherein almost 25 metabolites associated with the cell death pathway deciphered a significant variation. Therefore, this proof-of-concept personalized nanodelivery warrants further preclinical and clinical evaluations for the management of PC.

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“…The studies was perform to Increase the bioavailability Embelin, reduce the dose of Embelin, prevent the degradation of Embelin in the GIT and explore the possibilities of administering Embelin in novel drug delivery system i.e. as phytosome 11,12,13 .…”

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confidence: 99%

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2022

IJPSR

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Embelin was one of active constituents of Embelia ribes Burm. f. Embelin has been reported to possess many pharmacological effects. The studies as was perform to enhance the bioavailability of poorly water soluble embelin, reduce the dose of Embelin, prevent the degradation of Embelin in the GIT. For this, phytosome, a novel drug delivery system, was adopted. Total six Embelin loaded phytosome complex formulations coded as EMBP1, EMBP2, EMBP3, EMBP4, EMBP5 and EMBP6 using soya lecithin and Chitosan in variable ratio were prepared by anti-solvent precipitation method and Rotary evaporation technique. The phytosome was characterized by parameters like percentage yield, particle size determination, entrapment efficiency, scanning electron microscopy (SEM), in-vitro release studies and establish drug release kinetic studies. Among six formulations, the Formulation EMBP5 well optimized. EMBP5 exhibits lowest 345.45 ±1.231 diameter. The entrapment efficiency of Embelin loaded phytosome complex varies from 64.99 ± 1.546 to 81.78 ± 1.151%. Embelin loaded phytosome complex formulation (EMBP5) exhibits highest of 81.78 ± 1.151% entrapment efficiency. SEM photomicrographs of optimized formulation (EMBP5) of Embelin loaded phytosome complex showed that the phytosomes are less spherical with smooth and rough surface and slightly aggregated. In-vitro dissolution study of phytosomes showed extended release pattern. From the data, the release of embelin from Embelin loaded phytosome complex was by fickian diffusion mechanism and followed first order kinetics (concentration dependant). INTRODUCTION:According to WHO, more than 80% people of the world shows their reliability towards herbal medicines. Active constituents extracted from plants have been used to treat various diseases since ancient times 1 . Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. However, the drug delivery system used for QUICK RESPONSE CODE

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Embelin as a Potential Drug Molecule: A Review

Cited by 7 publications

References 56 publications

Effect of Combination of Some Phytoconstituents of Pharmacological Interest on Cutaneous Wound Healing in Diabetic Rats

Effect of Combination of Some Phytoconstituents of Pharmacological Interest on Cutaneous Wound Healing in Diabetic Rats

Targeted Delivery Polymeric Nanosystem Reinforced by Synergism of Embilin and RPI-1 for Therapeutics of Pancreatic Cancer

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